DL-THREONINE METHYL ESTER HYDROCHLORIDE
- Product Name
- DL-THREONINE METHYL ESTER HYDROCHLORIDE
- CAS No.
- 62076-66-8
- Chemical Name
- DL-THREONINE METHYL ESTER HYDROCHLORIDE
- Synonyms
- methyl 2-amino-3-hydroxybutanoate;Methyl 2-aMino-3-hydroxybutanoate hydrochloride;3-NO2-Tyr-OH;H-DL-Thr-OMe.HCl;DL-THREONINE METHYL ESTER HYDROCHLORIDE;Threonine,methyl ester, hydrochloride (1:1);DL-THREONINE METHYL ESTER HYDROCHLORIDE USP/EP/BP
- CBNumber
- CB9101261
- Molecular Formula
- C5H12ClNO3
- Formula Weight
- 169.61
- MOL File
- 62076-66-8.mol
DL-THREONINE METHYL ESTER HYDROCHLORIDE Property
- Melting point:
- 125℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- color
- Beige
Safety
- WGK Germany
- 3
- HS Code
- 2922500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S765430
- Product name
- DL-THREONINE METHYL ESTER HYDROCHLORIDE
- Purity
- AldrichCPR
- Packaging
- 50mg
- Price
- $28.6
- Updated
- 2022/05/15
- Product number
- T405555
- Product name
- DL-THREONINE METHYL ESTER HYDROCHLORIDE
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- AS42929-rac
- Product name
- Methyl 2-amino-3-hydroxybutanoate hydrochloride
- Purity
- 97+%
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- CS-W022797
- Product name
- Methyl2-amino-3-hydroxybutanoatehydrochloride
- Packaging
- 10g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- OR928456
- Product name
- DL-THREONINE METHYL ESTER HYDROCHLORIDE
- Purity
- 97%
- Packaging
- 100g
- Price
- $493
- Updated
- 2021/12/16
DL-THREONINE METHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Dl-threonine methyl ester HCl
Synthesis
67-56-1
28954-12-3
39994-75-7
The general procedure for the synthesis of L-threonine methyl ester hydrochloride from methanol and (2S,3S)-2-amino-3-hydroxybutanoic acid was as follows: a mixture of (2S,3S)-2-amino-3-hydroxybutanoic acid (5.4 g, 24.6 mmol) and 6N HCl (60 mL) was refluxed for 5 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was extracted with ether (3 x 70 mL) to remove the benzoic acid. The aqueous phase was concentrated to dryness under reduced pressure and the residue was further dried under high vacuum overnight to give crude allo-L-threonine. Methanol (25 mL) was cooled to 0 °C and thionyl chloride (1.80 mL, 25.2 mmol) was added slowly and dropwise. Crude allo-L-threonine was added to the resulting HCl methanol solution and the reaction mixture was heated to reflux for 1 hour. After completion of the reaction, the solvent was removed under vacuum and another batch of HCl methanol solution prepared in the same manner was added and again heated to reflux for 1 hour. Finally, the solvent was removed in vacuum to give allo-L-threonine methyl ester hydrochloride (4.15 g, 98% overall yield in two steps) as a red solid. The product was confirmed by 1H NMR (300 MHz, CD3OD): δ1.27 (d, J=6.6 Hz, 3H), 4.03 (d, J=3.3 Hz, 1H), 4.27-4.33 (m, 1H); 13C NMR (75 MHz, CD3OD): δ17.13,58.17,65.11,167.62; MS ( ESI, positive): m/z 134 [M+H]+.
References
[1] Journal of Organic Chemistry, 2002, vol. 67, # 5, p. 1536 - 1547
[2] Helvetica Chimica Acta, 1957, vol. 40, p. 1531,1544
[3] Journal of Organic Chemistry, 1997, vol. 62, # 21, p. 7364 - 7375
[4] Journal of Organic Chemistry, 2003, vol. 68, # 26, p. 10046 - 10057
[5] Journal of the American Chemical Society, 2007, vol. 129, # 18, p. 6017 - 6021
DL-THREONINE METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
DL-THREONINE METHYL ESTER HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
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- 6100
- Advantage
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View Lastest Price from DL-THREONINE METHYL ESTER HYDROCHLORIDE manufacturers
- Product
- DL-Thr-Ome.HCl 62076-66-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-04-08
- Product
- DL-THREONINE METHYL ESTER HYDROCHLORIDE 62076-66-8
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2020-01-08