4-(Chlorosulfonyl)-benzoic acid methyl ester
- Product Name
- 4-(Chlorosulfonyl)-benzoic acid methyl ester
- CAS No.
- 69812-51-7
- Chemical Name
- 4-(Chlorosulfonyl)-benzoic acid methyl ester
- Synonyms
- Methyl p-(chlorosulfonyl)benzoate;4-Carbomethoxybenzenesulfonyl chloride;p-(Carbomethoxy)benzenesulfonyl chloride;4-(Methoxycarbonyl)benzenesulfonyl chloride;METHYL 4-(CHLOROSULFONYL)BENZOATE(RS20013285);Benzoic acid, 4-(chlorosulfonyl)-, Methyl ester;methyl 4-(chlorosulfonyl)benzoate(SALTDATA: FREE);Benzoic acid, 4-(chlorosulfonyl)-, methyl ester (9CI)
- CBNumber
- CB91016876
- Molecular Formula
- C8H7ClO4S
- Formula Weight
- 234.66
- MOL File
- 69812-51-7.mol
4-(Chlorosulfonyl)-benzoic acid methyl ester Property
- Melting point:
- 72-73℃
- Boiling point:
- 126 °C(Press: 0.05 Torr)
- Density
- 1.431
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Faint to light orange
- InChI
- InChI=1S/C8H7ClO4S/c1-13-8(10)6-2-4-7(5-3-6)14(9,11)12/h2-5H,1H3
- InChIKey
- MOFQDKOKODUZPK-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(S(Cl)(=O)=O)C=C1
Safety
- RIDADR
- 3261
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
N-Bromosuccinimide Price
- Product number
- M295620
- Product name
- Methyl4-(chlorosulfonyl)benzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M295620
- Product name
- Methyl4-(chlorosulfonyl)benzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W7954
- Product name
- 4-Chlorosulfonylbenzoicacidmethylester
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- FC32866
- Product name
- 4-Chlorosulfonylbenzoic acid methyl ester
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC32866
- Product name
- 4-Chlorosulfonylbenzoic acid methyl ester
- Packaging
- 5G
- Price
- $115
- Updated
- 2021/12/16
4-(Chlorosulfonyl)-benzoic acid methyl ester Chemical Properties,Usage,Production
Uses
4-(Chlorosulfonyl)-benzoic acid methyl ester can be used as an organic synthesis raw material for the preparation of other heterocyclic compounds.
Synthesis
67-56-1
7516-60-1
69812-51-7
General procedure for the synthesis of methyl 4-(chlorosulfonyl)benzoate from methanol and 4-(chlorosulfonyl)benzoyl chloride: 4-chlorosulfonylbenzoic acid (5 g, 23 mmol) was dissolved in dichloroethane (10 mL), thionyl chloride (20 mL) was added, and the reaction mixture was heated to 80 °C, and the reaction was maintained at this temperature for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated by rotary evaporator to give a brown solid. The resulting solid was cooled in an ice bath for 5 min, followed by the slow addition of pre-cooled methanol (40 mL) at 0 °C with stirring, a process that lasted for 5 min. The reaction mixture was gradually warmed up to room temperature and stirring was continued for 10 minutes. Finally, ice-cold water (40 mL) was added, at which time a white solid precipitated, and the solid product was collected by filtration and dried under vacuum to afford pure methyl 4-(chlorosulfonyl)benzoate (4.5 g, 84% yield). The product was characterized by NMR (400 MHz, DMSO-d6): δ, ppm: 3.84 (s, 3H), 7.70 (d, 2H, J = 8.4Hz), 7.93 (d, 2H, J = 8.4Hz).
References
[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 73-74
[2] Patent: US9247759, 2016, B2. Location in patent: Page/Page column 144; 145
[3] Recueil des Travaux Chimiques des Pays-Bas, 1957, vol. 76, p. 129,138,145
4-(Chlorosulfonyl)-benzoic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Chlorosulfonyl)-benzoic acid methyl ester manufacturers
- Product
- 4-(Chlorosulfonyl)-benzoic acid methyl ester 69812-51-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12