ChemicalBook > CAS DataBase List > 4-(Chlorosulfonyl)-benzoic acid methyl ester

4-(Chlorosulfonyl)-benzoic acid methyl ester

Product Name
4-(Chlorosulfonyl)-benzoic acid methyl ester
CAS No.
69812-51-7
Chemical Name
4-(Chlorosulfonyl)-benzoic acid methyl ester
Synonyms
Methyl p-(chlorosulfonyl)benzoate;4-Carbomethoxybenzenesulfonyl chloride;p-(Carbomethoxy)benzenesulfonyl chloride;4-(Methoxycarbonyl)benzenesulfonyl chloride;METHYL 4-(CHLOROSULFONYL)BENZOATE(RS20013285);Benzoic acid, 4-(chlorosulfonyl)-, Methyl ester;methyl 4-(chlorosulfonyl)benzoate(SALTDATA: FREE);Benzoic acid, 4-(chlorosulfonyl)-, methyl ester (9CI)
CBNumber
CB91016876
Molecular Formula
C8H7ClO4S
Formula Weight
234.66
MOL File
69812-51-7.mol
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4-(Chlorosulfonyl)-benzoic acid methyl ester Property

Melting point:
72-73℃
Boiling point:
126 °C(Press: 0.05 Torr)
Density 
1.431
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
color 
Faint to light orange
InChI
InChI=1S/C8H7ClO4S/c1-13-8(10)6-2-4-7(5-3-6)14(9,11)12/h2-5H,1H3
InChIKey
MOFQDKOKODUZPK-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=C(S(Cl)(=O)=O)C=C1
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Safety

RIDADR 
3261
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

TRC
Product number
M295620
Product name
Methyl4-(chlorosulfonyl)benzoate
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
M295620
Product name
Methyl4-(chlorosulfonyl)benzoate
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32866
Product name
4-Chlorosulfonylbenzoic acid methyl ester
Packaging
5G
Price
$115
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC32866
Product name
4-Chlorosulfonylbenzoic acid methyl ester
Packaging
2g
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
020427
Product name
4-Chlorosulfonyl-benzoic acid methyl ester
Packaging
1g
Price
$174
Updated
2021/12/16
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4-(Chlorosulfonyl)-benzoic acid methyl ester Chemical Properties,Usage,Production

Uses

4-(Chlorosulfonyl)-benzoic acid methyl ester can be used as an organic synthesis raw material for the preparation of other heterocyclic compounds.

Synthesis

67-56-1

7516-60-1

69812-51-7

General procedure for the synthesis of methyl 4-(chlorosulfonyl)benzoate from methanol and 4-(chlorosulfonyl)benzoyl chloride: 4-chlorosulfonylbenzoic acid (5 g, 23 mmol) was dissolved in dichloroethane (10 mL), thionyl chloride (20 mL) was added, and the reaction mixture was heated to 80 °C, and the reaction was maintained at this temperature for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated by rotary evaporator to give a brown solid. The resulting solid was cooled in an ice bath for 5 min, followed by the slow addition of pre-cooled methanol (40 mL) at 0 °C with stirring, a process that lasted for 5 min. The reaction mixture was gradually warmed up to room temperature and stirring was continued for 10 minutes. Finally, ice-cold water (40 mL) was added, at which time a white solid precipitated, and the solid product was collected by filtration and dried under vacuum to afford pure methyl 4-(chlorosulfonyl)benzoate (4.5 g, 84% yield). The product was characterized by NMR (400 MHz, DMSO-d6): δ, ppm: 3.84 (s, 3H), 7.70 (d, 2H, J = 8.4Hz), 7.93 (d, 2H, J = 8.4Hz).

References

[1] Patent: WO2005/66126, 2005, A1. Location in patent: Page/Page column 73-74
[2] Patent: US9247759, 2016, B2. Location in patent: Page/Page column 144; 145
[3] Recueil des Travaux Chimiques des Pays-Bas, 1957, vol. 76, p. 129,138,145

4-(Chlorosulfonyl)-benzoic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-(Chlorosulfonyl)-benzoic acid methyl ester manufacturers

Career Henan Chemical Co
Product
4-(Chlorosulfonyl)-benzoic acid methyl ester 69812-51-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

69812-51-7, 4-(Chlorosulfonyl)-benzoic acid methyl esterRelated Search:

Phthalic acid 4-(CHLOROSULFONYL)BENZOIC ACID BUTTPARK 88\11-08 BUTYL 4-(CHLOROSULFONYL)BENZOATE 4-CHLOROSULFONYL-BENZOIC ACID ETHYL ESTER propyl 3-bromo-4-(chlorosulfonyl)benzoate butyl 3-bromo-4-(chlorosulfonyl)benzoate methyl 4-(chlorosulfonyl)-3-nitrobenzoate 4-(Chlorosulfonyl)-benzoic acid methyl ester BUTTPARK 147\11-86 ethyl 3-bromo-4-(chlorosulfonyl)benzoate PROPYL 4-(CHLOROSULFONYL)BENZOATE ISOPROPYL 4-(CHLOROSULFONYL)BENZOATE

  • methyl 4-(chlorosulfonyl)benzoate(SALTDATA: FREE)
  • 4-(Methoxycarbonyl)benzenesulfonyl chloride
  • 4-Carbomethoxybenzenesulfonyl chloride
  • Methyl p-(chlorosulfonyl)benzoate
  • p-(Carbomethoxy)benzenesulfonyl chloride
  • Benzoic acid, 4-(chlorosulfonyl)-, Methyl ester
  • METHYL 4-(CHLOROSULFONYL)BENZOATE(RS20013285)
  • Benzoic acid, 4-(chlorosulfonyl)-, methyl ester (9CI)
  • 69812-51-7
  • SULFONYLHALIDE