Methyl 3-hydroxy-4-nitrobenzoate

Application

Product Name: Methyl 3-hydroxy-4-nitrobenzoate
CAS No.: 713-52-0
Chemical Name: Methyl 3-hydroxy-4-nitrobenzoate
Synonyms: TIMTEC-BB SBB002401;RARECHEM AL BF 0673;Vibegron Impurity 10;3-HYDROXY-4-NITROMETHYLBENZOATE;METHYL 3-HYDROXY-4-NITROBENZOATE;Methyl3-Hydroxy-4-nitrobenzoate>Methyl3-hydroxy-4-nitrobenzoate,98%;4-Nitro-3-hydroxybenzoic acid methyl ester;3-HYDROXY-4-NITROBENZOIC ACID METHYL ESTER;Benzoic acid, 3-hydroxy-4-nitro-, Methyl ester
CBNumber: CB9101827
Molecular Formula: C8H7NO5
Formula Weight: 197.14
MOL File: 713-52-0.mol

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Methyl 3-hydroxy-4-nitrobenzoate Property

Melting point:: 90-91°C
Boiling point:: 346.4±27.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 6.05±0.13(Predicted)
color: Light yellow to Amber to Dark green
BRN: 2583832
CAS DataBase Reference: 713-52-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Irritant
HS Code: 2918290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2250
Product name: Methyl 3-Hydroxy-4-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 5g
Price: $71
Updated: 2025/07/31

TCI Chemical

Product number: M2250
Product name: Methyl 3-Hydroxy-4-nitrobenzoate
Purity: >98.0%(GC)
Packaging: 25g
Price: $237
Updated: 2025/07/31

TRC

Product number: M323468
Product name: Methyl 3-Hydroxy-4-nitrobenzoate
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-98
Product name: Methyl 3-hydroxy-4-nitrobenzoate
Packaging: 5G
Price: $104
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-1-98
Product name: Methyl 3-hydroxy-4-nitrobenzoate
Packaging: 10g
Price: $136
Updated: 2021/12/16

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Methyl 3-hydroxy-4-nitrobenzoate Chemical Properties,Usage,Production

Application

Methyl 3-hydroxy-4-nitrobenzoate is an organic intermediate that can be obtained by esterification of 3-hydroxy-4-nitrobenzoic acid. It can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory research and development processes and chemical production processes.

Synthesis

67-56-1

619-14-7

713-52-0

Concentrated sulfuric acid (0.5 mL) was slowly added dropwise to a solution of 3-hydroxy-4-nitrobenzoic acid (1.88 g, 10.3 mmol) dissolved in undried HPLC-grade methanol (60 mL), and the reaction mixture was subsequently heated to reflux for 18 hours. Upon completion of the reaction, sodium bicarbonate was added to the reaction solution to neutralize the acidity, followed by evaporation of the solvent under reduced pressure. To the residue, water and ethyl acetate were added for extraction and the aqueous layer was separated. The aqueous layer was further extracted five times with ethyl acetate. All organic layers were combined, washed twice with saturated brine, dried over anhydrous magnesium sulfate, and finally concentrated under reduced pressure to remove the solvent to give methyl 3-hydroxy-4-nitrobenzoate as yellow crystals with a yield of 2.00 g (99% yield) and a melting point of 89.5-90.5°C (literature values: 86-88°C, 91-92°C). UV spectrum (methanol): λmax = 238, 270, 351 nm. infrared spectrum (ATR): ν = 3310, 3124, 3050, 2962, 2842, 1720, 1622, 1587, 1521, 1476, 1434, 1323, 1283, 1222, 1147, 1098, 1067, 967, 891, 843, 798, 780, 743, 666 cm-1.1H NMR (500 MHz, CDCl3): δ=3.96 (s, 3H), 7.61 (dd, J=8.8, 1.7 Hz, 1H), 7.83 (d, J=1.7 Hz, 1H), 8.17 (d, J=8.8 Hz, 1H), 10.50 (s , 1H).13C NMR and DEPT (125 MHz, CDCl3): δ = 53.08 (CH3), 120.73 (CH), 121.80 (CH), 125.41 (CH), 135.90 (C), 138.10 (C), 154.79 (C), 164.97 (C=O). Mass spectrum (ESI, -10V): m/z=196 ([M-H]-). Calculated elemental analysis (C8H7NO5): C 48.74%, H 3.58%, N 7.10%; measured values: C 48.58%, H 3.44%, N 7.25%.

References

[1] Synlett, 2008, # 11, p. 1698 - 1702
[2] Organic and Biomolecular Chemistry, 2012, vol. 10, # 15, p. 2928 - 2933
[3] Synlett, 2015, vol. 26, # 9, p. 1175 - 1178
[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8219 - 8248
[5] Tetrahedron, 2012, vol. 68, # 33, p. 6727 - 6736

Methyl 3-hydroxy-4-nitrobenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 3-hydroxy-4-nitrobenzoate Suppliers

Americas 1 China 150 Europe 1 Germany 3 India 8 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 13 United States 20 Global 199

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View Lastest Price from Methyl 3-hydroxy-4-nitrobenzoate manufacturers

Henan Fengda Chemical Co., Ltd

Product: Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100 tons
Release date: 2020-01-10

Career Henan Chemical Co

Product: Methyl 3-hydroxy-4-nitrobenzoate 713-52-0
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-18

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RARECHEM AL BF 0673

TIMTEC-BB SBB002401

METHYL 3-HYDROXY-4-NITROBENZOATE

3-HYDROXY-4-NITROMETHYLBENZOATE

3-HYDROXY-4-NITROBENZOIC ACID METHYL ESTER

4-Nitro-3-hydroxybenzoic acid methyl ester

Benzoic acid, 3-hydroxy-4-nitro-, Methyl ester

Methyl3-hydroxy-4-nitrobenzoate,98%

Methyl3-Hydroxy-4-nitrobenzoate&gt

Methyl 3-hydroxy-4-nitrobenzoate ISO 9001：2015 REACH

Vibegron Impurity 10

713-52-0

1831-72-3

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Aromatic Esters