4,5,6,7-TETRABROMOBENZOTRIAZOLE
- Product Name
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
- CAS No.
- 17374-26-4
- Chemical Name
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
- Synonyms
- TBB;TBBT;NSC 231634;7-tetrabromo-;CK2 INHIBITOR;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I
- CBNumber
- CB9104424
- Molecular Formula
- C6HBr4N3
- Formula Weight
- 434.71
- MOL File
- 17374-26-4.mol
4,5,6,7-TETRABROMOBENZOTRIAZOLE Property
- Melting point:
- 262-266°C
- Boiling point:
- 552.5±45.0 °C(Predicted)
- Density
- 2.840±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 28 mg/mL
- pka
- 3.87±0.40(Predicted)
- form
- solid
- color
- white
- λmax
- 300nm(MeOH)(lit.)
Safety
- WGK Germany
- 3
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T0826
- Product name
- TBB
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $282
- Updated
- 2024/03/01
- Product number
- 218697
- Product name
- Casein Kinase II Inhibitor I
- Packaging
- 10mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- T2920
- Product name
- 4,5,6,7-Tetrabromobenzotriazole
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 10mg
- Price
- $103
- Updated
- 2022/04/27
- Product number
- T2920
- Product name
- 4,5,6,7-Tetrabromobenzotriazole
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 50mg
- Price
- $373
- Updated
- 2024/03/01
- Product number
- 14453
- Product name
- TBB
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
Uses
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
Biological Activity
A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Biochem/physiol Actions
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
storage
Store at -20°C
4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers
- Product
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE 17374-26-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01