ChemicalBook > CAS DataBase List > 4,5,6,7-TETRABROMOBENZOTRIAZOLE

4,5,6,7-TETRABROMOBENZOTRIAZOLE

Product Name
4,5,6,7-TETRABROMOBENZOTRIAZOLE
CAS No.
17374-26-4
Chemical Name
4,5,6,7-TETRABROMOBENZOTRIAZOLE
Synonyms
TBB;TBBT;NSC 231634;7-tetrabromo-;CK2 INHIBITOR;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I
CBNumber
CB9104424
Molecular Formula
C6HBr4N3
Formula Weight
434.71
MOL File
17374-26-4.mol
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4,5,6,7-TETRABROMOBENZOTRIAZOLE Property

Melting point:
262-266°C
Boiling point:
552.5±45.0 °C(Predicted)
Density 
2.840±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 28 mg/mL
pka
3.87±0.40(Predicted)
form 
solid
color 
white
λmax
300nm(MeOH)(lit.)
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T0826
Product name
TBB
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$282
Updated
2024/03/01
Sigma-Aldrich
Product number
218697
Product name
Casein Kinase II Inhibitor I
Packaging
10mg
Price
$144
Updated
2024/03/01
TCI Chemical
Product number
T2920
Product name
4,5,6,7-Tetrabromobenzotriazole
Purity
>97.0%(HPLC)(T)
Packaging
10mg
Price
$103
Updated
2022/04/27
TCI Chemical
Product number
T2920
Product name
4,5,6,7-Tetrabromobenzotriazole
Purity
>97.0%(HPLC)(T)
Packaging
50mg
Price
$373
Updated
2024/03/01
Cayman Chemical
Product number
14453
Product name
TBB
Purity
≥98%
Packaging
5mg
Price
$38
Updated
2024/03/01
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4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.

Biological Activity

A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.

Biochem/physiol Actions

TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.

storage

Store at -20°C

4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5,6,7-TETRABROMOBENZOTRIAZOLE Suppliers

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View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers

Career Henan Chemical Co
Product
4,5,6,7-TETRABROMOBENZOTRIAZOLE 17374-26-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95-99%
Supply Ability
500kg/month
Release date
2019-08-01

17374-26-4, 4,5,6,7-TETRABROMOBENZOTRIAZOLERelated Search:

2-(2H-Benzothiazol-2-yl)-6-(dodecyl)-4-methylphenol Dibenzothiophene Centchroman CASEIN KINASE II 5-BROMO-1H-BENZOTRIAZOLE 4,5,6,7-TETRABROMOBENZOTRIAZOLE

  • NSC 231634
  • TBB
  • TBBT
  • 7-tetrabromo-
  • NSC 231634; TBB (ENZYME INHIBITOR);1H-BENZOTRIAZOLE; 4;5;6;7-TETRABROMO-
  • 4,5,6,7-Tetrabromo-1H-benzotriazole
  • CASEIN KINASE II INHIBITOR *TBB**
  • 4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt
  • 1H-Benzotriazole, 4,5,6,7-tetrabroMo-
  • TBB (enzyMe inhibitor)
  • 4,5,6,7-TetrabroMo-1H-benzo[d][1,2,3]triazole
  • TBB(NSC 231634)
  • 4,5,6,7-tetrabromo-2H-benzotriazole
  • 4,5,6,7-Tetrabromobenzotriazole, 97%, selective, cell-permeable casein kinase-2 (CK2) inhibitor
  • 4,5,6,7-TETRABROMO-2-AZABENZIMIDAZOLE
  • 4,5,6,7-TETRABROMOBENZOTRIAZOLE
  • CASEIN KINASE II INHIBITOR I
  • CK2 INHIBITOR
  • 4,5,6,7-Tetrabromotriazole
  • YM905 free base
  • 4,5,6,7-Tetrabromobenzotriazole, selective, cell-permeable casein kinase-2 (CK2) inhibitor
  • 17374-26-4
  • 35-95-2
  • C6HN3Br4
  • C6HBr4N3
  • Casein Kinase (CK)
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • PI3K/Akt/mTOR
  • Protein Kinase
  • Protein Kinase Inhibitors and Activators