4,5,6,7-TETRABROMOBENZOTRIAZOLE
- Product Name
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
- CAS No.
- 17374-26-4
- Chemical Name
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE
- Synonyms
- TBB;TBBT;NSC 231634;7-tetrabromo-;CK2 INHIBITOR;TBB(NSC 231634);YM905 free base;TBB (enzyMe inhibitor);4,5,6,7-Tetrabromotriazole;CASEIN KINASE II INHIBITOR I
- CBNumber
- CB9104424
- Molecular Formula
- C6HBr4N3
- Formula Weight
- 434.71
- MOL File
- 17374-26-4.mol
4,5,6,7-TETRABROMOBENZOTRIAZOLE Property
- Melting point:
- 262-266°C
- Boiling point:
- 552.5±45.0 °C(Predicted)
- Density
- 2.840±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 28 mg/mL
- pka
- 3.87±0.40(Predicted)
- form
- solid
- color
- white
- λmax
- 300nm(MeOH)(lit.)
Safety
- WGK Germany
- 3
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T0826
- Product name
- TBB
- Purity
- ≥98% (HPLC), solid
- Packaging
- 10mg
- Price
- $282
- Updated
- 2024/03/01
- Product number
- 218697
- Product name
- Casein Kinase II Inhibitor I
- Packaging
- 10mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- T2920
- Product name
- 4,5,6,7-Tetrabromobenzotriazole
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 10mg
- Price
- $103
- Updated
- 2022/04/27
- Product number
- T2920
- Product name
- 4,5,6,7-Tetrabromobenzotriazole
- Purity
- >97.0%(HPLC)(T)
- Packaging
- 50mg
- Price
- $373
- Updated
- 2024/03/01
- Product number
- 14453
- Product name
- TBB
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
4,5,6,7-TETRABROMOBENZOTRIAZOLE Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
TBB is one of the most selective protein kinase inhibitors known, and when tested against a panel of 33 serine/threonine and tyrosine protein kinases, only three exhibited moderate inhibition by TBB, with Ki values one to two orders of magnitude higher than that for CK2.
Biological Activity
A cell-permeable, selective inhibitor of casein kinase-2 (CK2) (IC 50 = 0.9 and 1.6 μ M for rat liver and human recombinant CK2 respectively). Exhibits modest discrimination between CK2 subunits, with K i values ranging from 80 nM to 210 nM. Acts in an ATP/GTP-competitive manner and displays one to two orders of magnitude selectivity over a panel of 33 protein kinases.
Biochem/physiol Actions
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
storage
Store at -20°C
4,5,6,7-TETRABROMOBENZOTRIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
4,5,6,7-TETRABROMOBENZOTRIAZOLE Suppliers
View Lastest Price from 4,5,6,7-TETRABROMOBENZOTRIAZOLE manufacturers
- Product
- 4,5,6,7-TETRABROMOBENZOTRIAZOLE 17374-26-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 500kg/month
- Release date
- 2019-08-01