Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)

Product Name: Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
CAS No.: 83393-46-8
Chemical Name: Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
Synonyms: Compound 83393-46-8;3-ACETYL-7(1H)-AZAINDOLE;3-Acetyl-1H-pyrrolo[2,3-b]pyridine;1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone;Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-;Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
CBNumber: CB91057411
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 83393-46-8.mol

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Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Property

Melting point:: 202-206°C
Boiling point:: 399.5±42.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.94±0.20(Predicted)
form: solid
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38-43
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B529770
Product name: 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: W8665
Product name: 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging: 1g
Price: $96
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK1207881
Product name: 3-Acetyl-7-azaindole
Purity: 97%
Packaging: 1g
Price: $138
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-1-0S
Product name: 1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging: 1g
Price: $264
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK1207881
Product name: 3-Acetyl-7-azaindole
Purity: 97%
Packaging: 5g
Price: $552
Updated: 2021/12/16

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Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone is an intermediate used in the preparation of vemurafenib, a kinase inhibitor for the treatment of BRAF-mutated melanoma and in other clinical studies.

Synthesis

271-63-6

75-36-5

83393-46-8

General procedure for the synthesis of 3-acetyl-7(1H)-azaindole from 7-azaindole and acetyl chloride: 7-azaindole (0.59 g, 5 mmol) was dissolved in 80 mL of dichloromethane, aluminum trichloride (3.39 g, 25 mmol) was added, followed by a slow dropwise addition of acetyl chloride (3.4 mL, 47.8 mmol). The reaction mixture was stirred at room temperature for 10 hours. Upon completion of the reaction, the reaction solution was placed in an ice bath and 20 mL of methanol was slowly added to quench the reaction. The reaction mixture was concentrated and 30 mL of water was added to the residue and the pH was adjusted with 1 N aqueous sodium hydroxide to about 4. The reaction solution was extracted with ethyl acetate (15 mL x 3), and the organic phases were combined, washed with saturated brine (20 mL x 2) and dried over anhydrous sodium sulfate. After filtration and concentration, the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=1:1, v/v) to give 0.72 g of a pale yellow solid in 90% yield.

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 6226 - 6227
[2] Patent: CN103508930, 2016, B. Location in patent: Paragraph 0296-0299
[3] Patent: CN104817490, 2017, B. Location in patent: Paragraph 0188; 0189
[4] Patent: US2007/112020, 2007, A1. Location in patent: Page/Page column 38
[5] Patent: WO2007/79239, 2007, A2. Location in patent: Page/Page column 83

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) manufacturers

Career Henan Chemical Co

Product: Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) 83393-46-8
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

83393-46-8, Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)Related Search:

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) METHYL 7-AZAINDOLE-3-GLYOXYLATE Ethanone, 2,2,2-trifluoro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo-, ethyl ester SINOVA SL-02580 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo- 4-BENZOYL-2-METHYL-1-[(7-OXIDO-1H-PYRROLO[2,3-B] PYRIDIN-3-YL)OXOACETYL]-PIPERAZINE Ethanone, 2-bromo-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- Ethanone, 2-chloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) ALFA-OXO-1H-PYRROLO-[2,3B]PYRIDINE-3-ACETIC ACID MONOPOTASSIUM SALT 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 2,2,2-TRIFLUORO-1-[1-(2-FLUOROBENZYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]-1-ETHANONE 1-(1-ETHYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-2,2,2-TRIFLUORO-1-ETHANONE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(4-METHOXY-7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(4-NITRO-7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE ETHYL 2-(1-[(4-METHOXYPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-2-OXOACETATE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 2,2,2-TRIFLUORO-1-(1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-1-ETHANONE

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)

3-ACETYL-7(1H)-AZAINDOLE

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-

3-Acetyl-1H-pyrrolo[2,3-b]pyridine

1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone

Compound 83393-46-8

83393-46-8

ACETYLGROUP