SINOVA SL-02580
- Product Name
- SINOVA SL-02580
- CAS No.
- 357263-13-9
- Chemical Name
- SINOVA SL-02580
- Synonyms
- CS-1404;BMS-806;BMS 806;DCC-2036;SINOVA SL-02580;BMS 806;BMS-806;BMS-806 (BMS 378806);BMS-378806 BMS378806;BMS-806; BMS 378806; BMS 806; BMS378806; BMS806;BMS 378806,BMS 806,Human immunodeficiency virus,inhibit,HIV,BMS-378806,BMS806,Inhibitor
- CBNumber
- CB2818106
- Molecular Formula
- C22H22N4O4
- Formula Weight
- 406.43
- MOL File
- 357263-13-9.mol
SINOVA SL-02580 Property
- Melting point:
- 236 °C
- Density
- 1.328
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥20.2 mg/mL in DMSO
- form
- solid
- pka
- 11.99±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- 18525
- Product name
- BMS-806
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 18525
- Product name
- BMS-806
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 18525
- Product name
- BMS-806
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
- Product number
- B595905
- Product name
- BMS806
- Packaging
- 25mg
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- B1533
- Product name
- BMS-378806
- Packaging
- 100mg
- Price
- $1029
- Updated
- 2021/12/16
SINOVA SL-02580 Chemical Properties,Usage,Production
Description
BMS-806 is a small molecule that inhibits the first step of HIV-1 infection by blocking the binding of host cell CD4 with viral gp120 protein. It binds the exterior envelope glycoprotein gp120 (Kd= 21.1 nM; Ki = 24.9 nM), blocking the conformational change that occurs with CD4 binding and preventing fusion of the viral and target cell membranes. BMS-806 is specific to HIV-1 irrespective of chemokine receptor preference, with no activity against HIV-2, SIV, or a panel of additional viruses.
Uses
BMS 806 is a small molecular inhibitor of HIV-1 virus which blocks the interaction between gp120 and CD4 cells.
target
CD4-gp120 interactions
References
[1] wang t1, zhang z, wallace ob, deshpande m, fang h, yang z, zadjura lm, tweedie dl, huang s, zhao f, ranadive s, robinson bs, gong yf, ricarrdi k, spicer tp, deminie c, rose r, wang hg, blair ws, shi py, lin pf, colonno rj, meanwell na. discovery of 4-benzoyl-1-[(4-methoxy-1h- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (r)-methylpiperazine (bms-378806): a novel hiv-1 attachment inhibitor that interferes with cd4-gp120 interactions. j med chem. 2003 sep 25;46(20):4236-9.
SINOVA SL-02580 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SINOVA SL-02580 manufacturers
- Product
- SINOVA SL-02580 357263-13-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25