ChemicalBook > CAS DataBase List > Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)

Product Name
Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
CAS No.
83393-46-8
Chemical Name
Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
Synonyms
Compound 83393-46-8;3-ACETYL-7(1H)-AZAINDOLE;3-Acetyl-1H-pyrrolo[2,3-b]pyridine;1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone;Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-;Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
CBNumber
CB91057411
Molecular Formula
C9H8N2O
Formula Weight
160.17
MOL File
83393-46-8.mol
More
Less

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Property

Melting point:
202-206°C
Boiling point:
399.5±42.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.94±0.20(Predicted)
form 
solid
Appearance
Light yellow to yellow Solid
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B529770
Product name
1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
W8665
Product name
1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging
1g
Price
$96
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK1207881
Product name
3-Acetyl-7-azaindole
Purity
97%
Packaging
1g
Price
$138
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-1-0S
Product name
1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone
Packaging
1g
Price
$264
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK1207881
Product name
3-Acetyl-7-azaindole
Purity
97%
Packaging
5g
Price
$552
Updated
2021/12/16
More
Less

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

1-(1H-Pyrrolo[2,3-b]pyridin-3-yl)ethanone is an intermediate used in the preparation of vemurafenib, a kinase inhibitor for the treatment of BRAF-mutated melanoma and in other clinical studies.

Synthesis

271-63-6

75-36-5

83393-46-8

General procedure for the synthesis of 3-acetyl-7(1H)-azaindole from 7-azaindole and acetyl chloride: 7-azaindole (0.59 g, 5 mmol) was dissolved in 80 mL of dichloromethane, aluminum trichloride (3.39 g, 25 mmol) was added, followed by a slow dropwise addition of acetyl chloride (3.4 mL, 47.8 mmol). The reaction mixture was stirred at room temperature for 10 hours. Upon completion of the reaction, the reaction solution was placed in an ice bath and 20 mL of methanol was slowly added to quench the reaction. The reaction mixture was concentrated and 30 mL of water was added to the residue and the pH was adjusted with 1 N aqueous sodium hydroxide to about 4. The reaction solution was extracted with ethyl acetate (15 mL x 3), and the organic phases were combined, washed with saturated brine (20 mL x 2) and dried over anhydrous sodium sulfate. After filtration and concentration, the residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=1:1, v/v) to give 0.72 g of a pale yellow solid in 90% yield.

References

[1] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 6226 - 6227
[2] Patent: CN103508930, 2016, B. Location in patent: Paragraph 0296-0299
[3] Patent: CN104817490, 2017, B. Location in patent: Paragraph 0188; 0189
[4] Patent: US2007/112020, 2007, A1. Location in patent: Page/Page column 38
[5] Patent: WO2007/79239, 2007, A2. Location in patent: Page/Page column 83

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) Suppliers

China 93 Europe 1 India 1 United Kingdom 1 United States 11 Global 107
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
1183
Advantage
57
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
Advantage
62
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Shanghai yirong biology science and technology co., ltd
Tel
18049974220
Fax
+86 (21) 51062076
Email
3060526242@qq.com
Country
China
ProdList
995
Advantage
60
Suzhou Guide Fine Material Co.Ltd.
Tel
0512-66627360 13914021065
Fax
0512-66627360
Email
706938434@qq.com
Country
China
ProdList
237
Advantage
60
Shanghai Synthfine Chemical Co.,Ltd
Tel
15921303235
Fax
QQ489466966
Email
sales@synthfine.com
Country
China
ProdList
1042
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
86(512)5235 8471 17715136450
Fax
86(512)5235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
4169
Advantage
58
shanghai cooperpharm co.,LTD .
Tel
+86-021-58975553
Fax
+86-021-58975554
Email
sales@cooperpharm.com
Country
China
ProdList
1210
Advantage
56
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai AQBioPharma Co., Ltd.
Tel
13661411401
Fax
51370935-8011
Email
yinglv.que@aqbiopharma.com.cn
Country
China
ProdList
2930
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Xingui Biotechnology Co., Ltd.
Tel
15121041756
Email
xingui2022@126.com
Country
China
ProdList
9979
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
NovoChemy Ltd.
Tel
86-(0)21-31261262 373522135
Fax
86-(0)21-33250524
Email
sales@novochemy.com
Country
China
ProdList
6498
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Shanghai Kahn Pharmaceutical Co., Ltd.
Tel
021-34979681; 17701870669
Fax
021-34979681
Email
41513101@qq.com
Country
China
ProdList
1785
Advantage
55
Zhengzhou Alfachem Co., Ltd.
Tel
0371-53765687 18937137882
Fax
QQ:2885373884
Email
2853979813@qq.com
Country
China
ProdList
7991
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4985
Advantage
55
Chengdu DingDang Pharmaceutical Co., Ltd.
Tel
028-86040038 13980902949;
Fax
028-85149890
Email
market@dingdangchem.com
Country
China
ProdList
1853
Advantage
55
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9279
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai QianYan Bio-technology Co., Ltd
Tel
02781293128
Email
orders@biochemsafebuy.com
Country
China
ProdList
9923
Advantage
55
Changzhou Hopschain Chemical Co.,Ltd.
Tel
0519-85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
Advantage
55
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai Civic Chemical Technology Co., Ltd.
Tel
021-34053660
Fax
QQ:2881074831
Email
sale2@labgogo.com
Country
China
ProdList
2018
Advantage
58
Nanjing KaiMubo Pharmaceutical Co., Ltd.
Tel
025-66162170
Fax
025-66162170
Country
China
ProdList
7181
Advantage
55
Shanghai Kangman Biological Technology Co., Ltd.
Tel
18800375331
Fax
021-50908862
Email
kangmansales@163.com
Country
China
ProdList
7570
Advantage
55
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
Sichuan BaiPeng Biotechnology Co., Ltd.
Tel
028-65791793 18140026355
Fax
QQ568470422
Email
568470422@qq.com
Country
China
ProdList
9997
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
15026866316
Email
180642609@qq.com
Country
China
ProdList
4967
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Nanjing SynTitan Pharmaceutical Co., Ltd.
Tel
025-57027686 17372956142
Fax
025-57027686
Email
li_lan@syntitan.com
Country
China
ProdList
9998
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
9972
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
wuhan Dekray Biomedical Technology Co.,Ltd
Tel
027-69573188 18221423799
Email
1503407886@qq.com
Country
China
ProdList
1439
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
More
Less

View Lastest Price from Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) manufacturers

Career Henan Chemical Co
Product
Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) 83393-46-8
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

83393-46-8, Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)Related Search:

Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) METHYL 7-AZAINDOLE-3-GLYOXYLATE Ethanone, 2,2,2-trifluoro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo-, ethyl ester SINOVA SL-02580 1H-Pyrrolo[2,3-b]pyridine-3-acetic acid, a-oxo- 4-BENZOYL-2-METHYL-1-[(7-OXIDO-1H-PYRROLO[2,3-B] PYRIDIN-3-YL)OXOACETYL]-PIPERAZINE Ethanone, 2-bromo-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- Ethanone, 2-chloro-1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI) ALFA-OXO-1H-PYRROLO-[2,3B]PYRIDINE-3-ACETIC ACID MONOPOTASSIUM SALT 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 2,2,2-TRIFLUORO-1-[1-(2-FLUOROBENZYL)-1H-PYRROLO[2,3-B]PYRIDIN-3-YL]-1-ETHANONE 1-(1-ETHYL-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-2,2,2-TRIFLUORO-1-ETHANONE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(4-METHOXY-7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(4-NITRO-7-OXY-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE ETHYL 2-(1-[(4-METHOXYPHENYL)SULFONYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-2-OXOACETATE 1-((R)-4-BENZOYL-2-METHYL-PIPERAZIN-1-YL)-2-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANE-1,2-DIONE 2,2,2-TRIFLUORO-1-(1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-1-ETHANONE

  • Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)- (9CI)
  • 3-ACETYL-7(1H)-AZAINDOLE
  • Ethanone, 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)-
  • 3-Acetyl-1H-pyrrolo[2,3-b]pyridine
  • 1-(1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone
  • Compound 83393-46-8
  • 83393-46-8
  • ACETYLGROUP