Rosopatamab

Product Name: Rosopatamab
CAS No.: 2260767-49-3
Chemical Name: Rosopatamab
Synonyms: Rosopatamab;Rosopatamab (anti-PSMA);Research Grade Rosopatamab;Research Grade Rosopatamab(DHG01304)
CBNumber: CB910616962
Formula Weight: 0
MOL File: Mol file

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Rosopatamab Property

form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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Rosopatamab Chemical Properties,Usage,Production

Uses

Rosopatamab (HuJ591) is a humanized antiPSMA IgG1 monoclonal antibody that can be used in cancer research, especially prostate cancer. Rosopatamab can be linked to the low-energy beta-emitting radioisotope lutetium-177 (177Lu) through the bifunctional chelator DOTA-NHS ester to obtain a radioimmunoconjugate that targets malignant prostate cells with high efficiency[1].

in vivo

Combination of ¹⁷⁷Lu-DOTA-rosopatamab (6 MBq, i.v., single) and Peposertib (HY-101570) achieves a 3 of 4 complete response rate in a LNCaP prostate cancer mice model^[2].
¹⁷⁷Lu-rosopatamab (anti-PSMA) (6 MBq, i.v., single) plus Peposertib (HY-101570) has 75% complete response (3/4) vs 25% complete response (1/4) in the 177Lu-anti-PSMA (6MBq) alone arm in the prostate BALB/c nude mice model^[3].

IC 50

RDC Antibody

References

[1] Antonini P, et al. 177Lu-DOTA-TLX591 safety, biodistribution and dosimetry study (ProstACT-SELECT)[J]. 2022.
[2] Johnstone CN, et al. DNA-Dependent Protein Kinase Inhibitor Peposertib Enhances Efficacy of 177Lu-Based Radioimmunotherapy in Preclinical Models of Prostate and Renal Cell Carcinoma. J Nucl Med. 2025 Jan 30:jnumed.124.268695. DOI:10.2967/jnumed.124.268695
[3] Johnstone C, et al. Addition of DNA dependent protein kinase (DNA-PK) inhibitor peposertib enhances efficacy of 177Lu-based radioimmunotherapy in pre-clinical models of prostate and renal cell carcinoma. 2023.

Rosopatamab Preparation Products And Raw materials

Raw materials

Preparation Products

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Rosopatamab Suppliers

China 13 United States 1 Global 14

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
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Guangzhou Hongyuan Chemical Co.,Ltd

Tel: 15817493340
Email: 981810490@qq.com
Country: China
ProdList: 1566
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Wuhan Chemstan Biotechnology Co., Ltd.

Tel: 027-65317797 15926423062
Fax: QQ：422450190
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TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
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Biolab Reagents

Tel: 027-65279366 18108604356
Email: products@biolabreagent.com
Country: China
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Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
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Shanghai Yifei Biotechnology Co. , Ltd.

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Email: customer_service@efebio.com
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Wanxin Biotechnology (Jiaxing) Co., LTD

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Email: 3956524501@qq.com
Country: China
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Atagenix Laboratories

Tel: 027-87008169 17762441161
Email: info@atagenix.com
Country: China
ProdList: 10001
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Rosopatamab

Research Grade Rosopatamab(DHG01304)

Research Grade Rosopatamab

Rosopatamab (anti-PSMA)

2260767-49-3