ChemicalBook > CAS DataBase List > Sontuzumab
Sontuzumab
- Product Name
- Sontuzumab
- CAS No.
- 372075-37-1
- Chemical Name
- Sontuzumab
- Synonyms
- Sontuzumab;Sontuzumab (anti-MUC1);Research Grade Sontuzumab;Research Grade Sontuzumab (DHD14202)
- CBNumber
- CB92128756
- Formula Weight
- 0
- MOL File
- Mol file
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Sontuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Sontuzumab Chemical Properties,Usage,Production
Uses
Sontuzumab (AS1402) is a humanizedised IgG1κ MUC1 specific monoclonal antibody. Sontuzumab binds the extracellular MUC1 peptide sequence PDTR with a Kd of ~1 nM. Sontuzumab can be used for the research of breast cancer[1].
References
[1] Pegram MD, et al. Phase I dose escalation pharmacokinetic assessment of intravenous humanized anti-MUC1 antibody AS1402 in patients with advanced breast cancer. Breast Cancer Res. 2009;11(5):R73. DOI:10.1186/bcr2409
[2] Snijdewint FG, et al. Antibody-dependent cell-mediated cytotoxicity can be induced by MUC1 peptide vaccination of breast cancer patients. Int J Cancer. 2001 Jul 1;93(1):97-106. DOI:10.1002/ijc.1286
Sontuzumab Preparation Products And Raw materials
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Preparation Products
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