ChemicalBook > CAS DataBase List > Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
Application- Product Name
- Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
- CAS No.
- 365996-30-1
- Chemical Name
- Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)
- Synonyms
- RB4005;N-Boc-1(S),2(R)-diaMinocyclohexane;(1S,2R)-2-(Boc-amino)cyclohexylamine;(1S,2R)-N1-Boc-1,2-cyclohexanediamine;(1S,2R)-cis-N-Boc-1,2-cyclohexanediamine;(1S,2R)-2-Amino-1-(Boc-amino)cyclohexane;(1S,2R)-BOC-1,2-Diaminocyclohexane (cis);Cis-(1S, 2R)-1N-Boc-cyclohexane-1,2-diamine;tert-butyl (1S,2R)-2-aminocyclohexylcarbamate;(1S,2R)-1,2-Diaminocyclohexane, N1-BOC protected
- CBNumber
- CB91071394
- Molecular Formula
- C11H22N2O2
- Formula Weight
- 214.3
- MOL File
- 365996-30-1.mol
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Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Property
- Boiling point:
- 322.1±31.0 °C(Predicted)
- Density
- 1.02
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to lump to clear liquid
- pka
- 12.26±0.40(Predicted)
- color
- White or Colorless to Almost white or Almost colorless
- InChI
- InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-7-5-4-6-8(9)12/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9+/m1/s1
- InChIKey
- AKVIZYGPJIWKOS-BDAKNGLRSA-N
- SMILES
- C(OC(C)(C)C)(=O)N[C@H]1CCCC[C@H]1N
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B3483
- Product name
- (1S,2R)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $61
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B3483
- Product name
- (1S,2R)-N1-(tert-Butoxycarbonyl)-1,2-cyclohexanediamine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $303
- Updated
- 2025/07/31
Apolloscientific
- Product number
- OR15997
- Product name
- (1S,2R)-Cyclohexane-1,2-diamine,N1-BOCprotected
- Packaging
- 5g
- Price
- $375
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4256-1-X5
- Product name
- (1S,2R)-Cyclohexane-1,2-diamine, N1-Boc protected
- Packaging
- 5G
- Price
- $413
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB60249
- Product name
- tert-Butyl ((1S,2R)-2-aminocyclohexyl)carbamate
- Packaging
- 250mg
- Price
- $50
- Updated
- 2021/12/16
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Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Chemical Properties,Usage,Production
Application
Cis-N-tert-butoxycarbonyl-1,2-cyclohexanediamine is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
Triphenylphosphine (14.3 g) was added to a THF (190 ml) solution containing tert-butyl S,2S)-2-hydroxycyclohexyl) carbamate (10.0 g), followed by ice cooling. Diethyl azodicarboxylate (40% in toluene) (24.3 g) and DPPA (15.3 g) were added dropwise to the reaction solution, followed by stirring at room temperature for 1 hour. The reaction solution was left overnight. The solvent was distilled away under reduced pressure. Water was added, and then a 20% sodium hydroxide aqueous solution was added. Then, the organic layers were collected. Water (30 ml) was added to the obtained organic layers, followed by heating to 60 C. A THF (40 ml) solution containing triphenylphosphine (14.3 g) was added dropwise, followed by reflux for 2.5 hours. The solvent was distilled away under ordinary pressure. Toluene was added, and the pH was adjusted with 3M hydrochloric acid to pH=1 or less. Then, the resulting aqueous layers were collected, ethyl acetate was added, and the pH was adjusted with a 20% sodium hydroxide aqueous solution to pH 12. The organic layers were collected and dried over anhydrous sodium sulfate. Light yellow oily matter of tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate (Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI))was thus obtained.
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) manufacturers
Shanghai Yongzeng Technology Co.,Ltd
- Product
- tert-Butyl ((1S,2R)-2-aminocyclohexyl)carbamate 365996-30-1
- Price
- US $0.00/gm
- Min. Order
- 100gm
- Purity
- 99%min
- Supply Ability
- 100kgs
- Release date
- 2024-09-06
Henan Fengda Chemical Co., Ltd
- Product
- Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI) 365996-30-1
- Price
- US $34.00-1.20/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
Career Henan Chemical Co
- Product
- Cis-(1S, 2R)-1N-Boc-cyclohexane-1,2-diamine 365996-30-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07
365996-30-1, Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)Related Search:
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1,2-Diaminocyclohexane
N-Boc-1,2-Diaminocyclohexane
1-N-BOC-1,2-CIS-CYCLOHEXYLDIAMINE
Carbamic acid, [(1S,2R)-2-aminocyclohexyl]-, 1,1-dimethylethyl ester (9CI)