N-Boc-1,2-Diaminocyclohexane

Product Name: N-Boc-1,2-Diaminocyclohexane
CAS No.: 317595-54-3
Chemical Name: N-Boc-1,2-Diaminocyclohexane
Synonyms: N-Boc-trans-1;N-BOC-1,2-DIAMINOCYCLOHEXANE;N-Boc-cyclohexane-1,2-diaMine;1-N-Boc-1,2-Cyclohexyldiamino;1-N-Boc-Amino-1,2-cyclohexaned;1-AMINO-2-(BOC-AMINO)CYCLOHEXANE;1-N-BOC-AMINO-1,2-CYCLOHEXANEDIAMINE;tert-Butyl (2-aminocyclohexyl)carbamate;Cyclohexane-1,2-diamine, 1-BOC protected;Carbamic acid, N-(2-aminocyclohexyl)-, 1,1-dimethylethyl ester
CBNumber: CB9292860
Molecular Formula: C11H22N2O2
Formula Weight: 214.3
MOL File: 317595-54-3.mol

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N-Boc-1,2-Diaminocyclohexane Property

Boiling point:: 322.1±31.0 °C(Predicted)
Density: 1.02±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 12.26±0.40(Predicted)
Appearance: Yellow to brown <39°C Solid,>41°C Liquid

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Safety

HS Code: 2902110000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB141996
Product name: tert-Butyl (2-aminocyclohexyl)carbamate
Packaging: 100mg
Price: $58
Updated: 2021/12/16

ChemScene

Product number: CS-W006385
Product name: tert-Butyl(2-aminocyclohexyl)carbamate
Packaging: 5g
Price: $105
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141996
Product name: tert-Butyl (2-aminocyclohexyl)carbamate
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 7344AJ
Product name: tert-Butyl(2-aminocyclohexyl)carbamate
Packaging: 1g
Price: $118
Updated: 2021/12/16

Apolloscientific

Product number: OR16029
Product name: Cyclohexane-1,2-diamine,1-BOCprotected
Packaging: 1g
Price: $124
Updated: 2021/12/16

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N-Boc-1,2-Diaminocyclohexane Chemical Properties,Usage,Production

Synthesis

24424-99-5

694-83-7

317595-54-3

GENERAL STEPS: An 800 mL methanol solution containing 16.53 g (0.453 mol) of dry HCl was slowly added dropwise to 51.78 g (0.453 mol) of trans-(1R,2R)-1,2-diaminocyclohexane dissolved in 80 mL of methanol, and the dropwise addition process lasted for 2 hours. After the dropwise addition, 50 mL of water was added, followed by the addition of 98.97 g (0.453 mol) of di-tert-butyl dicarbonate in batches and the addition process lasted for 1 hour. The reaction mixture was stirred for 2 hours, after which the methanol was removed by rotary evaporation. The residue was washed with 900 mL of ether, filtered to remove insoluble material and dried. The crude product was dissolved in 800 mL of water and then extracted with a mixture of 500 mL of dichloromethane and 340 mL of 2M NaOH. The organic layer was retained, dried with anhydrous magnesium sulfate and evaporated to remove the solvent. Finally, 67.87 g (70% yield) of trans-(1R,2R)-1-Boc-amino-2-aminocyclohexane was obtained by recrystallization from 900 mL of petroleum ether.

References

[1] Archiv der Pharmazie, 2012, vol. 345, # 11, p. 896 - 901
[2] Bulletin of the Chemical Society of Japan, 2017, vol. 90, # 3, p. 312 - 321
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3793 - 3797
[4] Patent: US5021571, 1991, A
[5] Patent: US5089663, 1992, A

N-Boc-1,2-Diaminocyclohexane Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-1,2-Diaminocyclohexane Suppliers

China 66 Europe 1 Germany 1 India 1 United Kingdom 4 United States 13 Global 86

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View Lastest Price from N-Boc-1,2-Diaminocyclohexane manufacturers

Career Henan Chemical Co

Product: N-Boc-1,2-Diaminocyclohexane 317595-54-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-02

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