N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide
- Product Name
- N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide
- CAS No.
- 86357-14-4
- Chemical Name
- N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide
- Synonyms
- Triacetylganciclovir;Ganciclovir Triacetate;Ganciclovir Impurity 6;Ganciclovir Impurity 29;Three acetyl ganciclovir;N-Acetyl-di-O-acetyl Ganciclovi;N-Acetyl-di-O-acetyl Ganciclovir;valganciclovirhydrochloride iMpurit 6;N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]met;N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methy
- CBNumber
- CB91073141
- Molecular Formula
- C15H19N5O7
- Formula Weight
- 381.34
- MOL File
- 86357-14-4.mol
N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide Property
- Melting point:
- 174 °C
- Density
- 1.50
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 8.74±0.20(Predicted)
- color
- White to Pale Beige
- CAS DataBase Reference
- 86357-14-4(CAS DataBase Reference)
Safety
- HS Code
- 2933.99.9701
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A3228
- Product name
- N-Acetyl-di-O-acetylganciclovir
- Packaging
- 1G
- Price
- $56
- Updated
- 2025/07/31
- Product number
- A167985
- Product name
- N-Acetyl-di-O-acetylGanciclovir
- Packaging
- 25mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- 001206
- Product name
- N-Acetyl-di-O-acetyl Ganciclovir
- Packaging
- 10mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 295327
- Product name
- N-Acetyl-di-O-acetyl ganciclovir
- Packaging
- 5mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- A167985
- Product name
- N-Acetyl-di-O-acetylGanciclovir
- Packaging
- 50mg
- Price
- $625
- Updated
- 2021/12/16
N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
Ganciclovir derivative.
Synthesis
86357-13-3
3056-33-5
86357-14-4
The general procedure for the synthesis of 2-((2-acetylamino-6-oxo-1H-purin-9(6H)-yl)methoxy)propane-1,3-diyl diacetate from 2-(acetyloxymethoxy)-1,3-propanediol diacetate and N-(9-acetyloxy-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide is as follows: first, 50.0 g ( 0.21 mol, 1.0 eq.) of 20.0-diacetylguanine, 104.2 g (0.42 mol, 2.0 eq.) of 1,3-diacetoxy-2-(acetyloxymethoxy)propane and 3.0 g (0.021 mol, 0.1 eq.) of boron trifluoride ether compounds were mixed with 200 g of N,N-dimethylformamide in a microwave reactor. The reaction mixture was heated to 100 °C and maintained at this temperature for 10 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the mixture was cooled to room temperature. Subsequently, 450 g of ethyl acetate was added to the mixture and refluxed for 1 hour, after which the temperature was reduced to 0-5 °C and maintained for 1 hour. After filtration and drying process, 68.3 g of triacetyl ganciclovir compound (2) was obtained in 85.3% yield and 95.6% purity, while 3.1% of compound (3) was obtained.
References
[1] Patent: CN108467396, 2018, A. Location in patent: Paragraph 0030; 0031; 0036; 0037; 0040; 0041; 0044; 0045
N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide manufacturers
- Product
- N-[9-[[2-(Acetyloxy)-1-[(acetyloxy)methyl]ethoxy]methyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]acetamide 86357-14-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5%
- Supply Ability
- 2000
- Release date
- 2025-06-19
- Product
- N-Acetyl-di-O-acetyl Ganciclovir 86357-14-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-07
- Product
- Triacetylganciclovir 86357-14-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-13