Methyl-3-bromopropiolate
Application- Product Name
- Methyl-3-bromopropiolate
- CAS No.
- 23680-40-2
- Chemical Name
- Methyl-3-bromopropiolate
- Synonyms
- 182050;Bexarotene Impurity 21;Methyl 3-bromopropynoate;Methyl-3-bromopropiolate;Methyl 3-bromoprop-2-ynoate;2-Propynoic acid, 3-broMo-, Methyl ester;Methyl-3-bromopropiolate ISO 9001：2015 REACH
- CBNumber
- CB91075079
- Molecular Formula
- C4H3BrO2
- Formula Weight
- 162.97
- MOL File
- 23680-40-2.mol
Methyl-3-bromopropiolate Property
- Boiling point:
- 40-45 °C(Press: 5 Torr)
- Density
- 1.723±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Appearance
- Colorless to light yellow <20°C Solid,>20°C Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311Call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M297008
- Product name
- Methyl3-bromopropiolate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 1628AB
- Product name
- Methyl3-bromopropiolate
- Packaging
- 250mg
- Price
- $163
- Updated
- 2021/12/16
- Product number
- HCH0369313
- Product name
- METHYL-3-BROMOPROPIOLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.77
- Updated
- 2021/12/16
- Product number
- AS91391
- Product name
- Methyl 3-Bromopropiolate
- Purity
- 95+%
- Packaging
- 5G
- Price
- $695
- Updated
- 2021/12/16
- Product number
- A180014
- Product name
- Methyl3-bromopropiolate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $698
- Updated
- 2021/12/16
Methyl-3-bromopropiolate Chemical Properties,Usage,Production
Application
3-Bromopropynate methyl ester is a pharmaceutical intermediate obtained by brominating methyl propynate with NBS. Literature reports its potential use in preparing a class of compounds for cartilage repair.
Synthesis Reference(s)
Synthetic Communications, 22, p. 567, 1992 DOI: 10.1080/00397919208019255
Synthesis
922-67-8
23680-40-2
The general procedure for the synthesis of methyl 3-bromopropiolate from methyl propiolate: methyl propiolate (60 g, 713.6 mmol) was dissolved in acetone (2 L), followed by the sequential addition of N-bromosuccinimide (147.22 g, 827.13 mmol) and silver nitrate (12.12 g, 71.37 mmol). A slight exothermic phenomenon was observed during the reaction and the reaction temperature was increased from 21°C to 32°C. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the resulting gray suspension was evaporated by vacuum to remove the solvent, pentane (100 mL) was added and filtered through Celite, and the filter cake was washed with additional pentane. The process was repeated twice and all filtrates were combined and vacuum evaporated to give 113 g of methyl 3-bromopropiolate in 98% yield, which contained about 10% unreacted material. The product was characterized by 1H NMR (400 MHz, CDCl3) with a chemical shift δ of 3.78 (s, 3H).
References
[1] Patent: WO2015/166373, 2015, A1. Location in patent: Page/Page column 148
[2] Organic Syntheses, 1997, vol. 74, p. 212 - 212
[3] Synthetic Communications, 1992, vol. 22, # 4, p. 567 - 572
[4] Patent: US2003/236264, 2003, A1. Location in patent: Page 44
[5] Patent: US2003/236270, 2003, A1. Location in patent: Page 33
Methyl-3-bromopropiolate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl-3-bromopropiolate manufacturers
- Product
- 2-Propynoic acid,3-bromo-, methyl ester 23680-40-2
- Price
- US $15.00/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20
- Release date
- 2022-01-12
- Product
- Methyl-3-bromopropiolate 23680-40-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12