4-(3-Pyridyl)-2-chloropyrimidine
- Product Name
- 4-(3-Pyridyl)-2-chloropyrimidine
- CAS No.
- 483324-01-2
- Chemical Name
- 4-(3-Pyridyl)-2-chloropyrimidine
- Synonyms
- 4-(3-Pyridyl)-2-chloropyrimidine;2-Chloro-4-(3-pyridyl)pyrimidine;2-Chloro-4-pyridin-3-yl-pyrimidine;PyriMidine, 2-chloro-4-(3-pyridinyl)-;4-(3-pyridyl)-2-chloropyrimidine:2-chloro-4-(3-pyridyl)pyrimidine:
- CBNumber
- CB91076955
- Molecular Formula
- C9H6ClN3
- Formula Weight
- 191.62
- MOL File
- 483324-01-2.mol
4-(3-Pyridyl)-2-chloropyrimidine Property
- Boiling point:
- 399.5±17.0 °C(Predicted)
- Density
- 1.309
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.34±0.12(Predicted)
- Appearance
- Yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B428638
- Product name
- 2-chloro-4-(pyridin-3-yl)pyrimidine
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FC148755
- Product name
- 2-Chloro-4-pyridin-3-yl-pyrimidine
- Packaging
- 50mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FC148755
- Product name
- 2-Chloro-4-pyridin-3-yl-pyrimidine
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FC148755
- Product name
- 2-Chloro-4-pyridin-3-yl-pyrimidine
- Packaging
- 250mg
- Price
- $400
- Updated
- 2021/12/16
- Product number
- HCH0358510
- Product name
- 4-(3-PYRIDYL)-2-CHLOROPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.06
- Updated
- 2021/12/16
4-(3-Pyridyl)-2-chloropyrimidine Chemical Properties,Usage,Production
Synthesis
3934-20-1
1692-25-7
483324-01-2
In a 250 mL three-neck flask, 2,4-dichloropyrimidine (5.0 g, 33.56 mmol) was dissolved in a solvent mixture of 1,4-dioxane and water (4:1, 50 mL) and pyridine-3-boronic acid (4.95 g, 40.27 mmol), potassium carbonate (9.28 g, 67.12 mmol) and Pd(dppf)Cl2 (2.45 g , 3.36 mmol). The system was displaced three times with argon, gradually heated to 90 °C and reacted for 4 hours. Upon completion of the reaction, the system was concentrated under reduced pressure to remove most of the solvent, ethyl acetate (150 mL) and water (100 mL) were added for extraction and separation, and then the aqueous phase was extracted with ethyl acetate (80 mL). The organic phases were combined and washed with water (80 mL×2) and saturated saline (80 mL×2) sequentially, and the organic phase was dried with anhydrous sodium sulfate for 3 h. The crude product was obtained by filtration and concentration. The crude product was stirred with mixed solvents of petroleum ether and ethyl acetate (6 mL) for 1 h, filtered and dried in vacuum to obtain 4.8 g of 2-chloro-4-(3-pyridinyl)pyrimidine in 74.6% yield with HPLC purity >95%.
References
[1] Patent: CN106243083, 2016, A. Location in patent: Paragraph 0037-0039; 0044-0046; 0051-0053
[2] Patent: WO2011/8788, 2011, A1. Location in patent: Page/Page column 28-29
[3] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3259 - 3263
[4] Patent: US2004/122237, 2004, A1. Location in patent: Page 179
[5] Patent: WO2013/66839, 2013, A2. Location in patent: Page/Page column 31
4-(3-Pyridyl)-2-chloropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(3-Pyridyl)-2-chloropyrimidine manufacturers
- Product
- 2-Chloro-4-pyridin-3-yl-pyriMidine 483324-01-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15