ChemicalBook > CAS DataBase List > 6-Bromoimidazo[1,2-a]pyrazine

6-Bromoimidazo[1,2-a]pyrazine

Product Name
6-Bromoimidazo[1,2-a]pyrazine
CAS No.
912773-24-1
Chemical Name
6-Bromoimidazo[1,2-a]pyrazine
Synonyms
6-BroMoiMidazo[1,2-a;6-BroMoidazo[1,2-a]pyrazine;6-BroMoiMidazo[1,2-a]pyra...;2-Bromopyrazino[4,5-a]pyrole;6-BROMOIMIDAZO[1,2-A]PYRAZINE;Imidazo[1,2-a]pyrazine, 6-bromo-;6-Bromoimidazo[1,2-a]pyrazine 98%
CBNumber
CB91091264
Molecular Formula
C6H4BrN3
Formula Weight
198.02
MOL File
912773-24-1.mol
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6-Bromoimidazo[1,2-a]pyrazine Property

Density 
1.89
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.60±0.30(Predicted)
Appearance
Light yellow to brown Solid
InChI
InChI=1S/C6H4BrN3/c7-5-4-10-2-1-8-6(10)3-9-5/h1-4H
InChIKey
KKMWDXNBIKMCEH-UHFFFAOYSA-N
SMILES
C12=NC=CN1C=C(Br)N=C2
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
B678025
Product name
6-Bromoimidazo[1,2-a]pyrazine
Packaging
50mg
Price
$60
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B12874
Product name
6-Bromoimidazo[1,2-a]pyrazine
Purity
95%
Packaging
1g
Price
$10
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
B12874
Product name
6-Bromoimidazo[1,2-a]pyrazine
Purity
95%
Packaging
5g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
W9370
Product name
6-Bromoimidazo[1,2-a]pyrazine
Packaging
1g
Price
$41
Updated
2021/12/16
Oakwood
Product number
067619
Product name
6-Bromoimidazo[1,2-a]pyrazine
Purity
97%
Packaging
1g
Price
$55
Updated
2021/12/16
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6-Bromoimidazo[1,2-a]pyrazine Chemical Properties,Usage,Production

Synthesis

59489-71-3

2032-35-1

912773-24-1

The general procedure for the synthesis of 2-bromoimidazo[1,2-a]pyrazines from 2-amino-5-bromopyrazines and bromoacetaldehyde diethyl acetal was as follows: a mixture of bromoacetaldehyde diethyl acetal (19.7 g, 0.1 mol) with 48% hydrobromic acid (4 mL) was heated to 140 °C under nitrogen protection and reacted for 1.5 hours. The reaction mixture was poured into a stirred suspension of sodium bicarbonate (40 g) with isopropanol (200 mL) and filtered after continued stirring for 10 minutes. To the filtrate was added 5-bromo-2-aminopyrazine (8.65 g, 0.05 mol) and the resulting solution was heated to reflux for 2 hours. After completion of the reaction, the solvent was removed by vacuum evaporation to give a dark brown viscous substance. The residue was washed with saturated sodium bicarbonate solution (150 mL) and extracted with dichloromethane (500 mL in two portions). The organic phases were combined, dried and vacuum evaporated to give a brown oil. The oily material was purified by fast chromatography using ethyl acetate as eluent to give 7.0 g of the target product 2-bromoimidazo[1,2-a]pyrazine as a light brown solid in 71% yield. The product was characterized by 1H-NMR (400 MHz, CDCl3): δ= 7.71 (s, 1H, Ar-H), 7.85 (s, 1H, Ar-H), 8.30 (s, 1H, Ar-H), 8.92 (s, 1H, Ar-H).

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 21, p. 8713 - 8722
[2] Patent: EP2818471, 2014, A1. Location in patent: Paragraph 0189; 0190

6-Bromoimidazo[1,2-a]pyrazine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Bromoimidazo[1,2-a]pyrazine manufacturers

Career Henan Chemical Co
Product
6-Bromoimidazo[1,2-a]pyrazine 912773-24-1
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

912773-24-1, 6-Bromoimidazo[1,2-a]pyrazineRelated Search:

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