2-methyl-4-pyridinecarboxylic acid methyl ester
- Product Name
- 2-methyl-4-pyridinecarboxylic acid methyl ester
- CAS No.
- 16830-24-3
- Chemical Name
- 2-methyl-4-pyridinecarboxylic acid methyl ester
- Synonyms
- Methyl 2-Methylisonicotinate;METHYL 2-METHYLISONICOTINIC ACID;2-Methylisonicotinicacid methylester;methyl 2-methylpyridine-4-carboxylate;Methyl 2-methylisopyridin-3-carboxylate;2-methyl-4-pyridinecarboxylic acid methyl ester;2-Methylpyridine-4-carboxylic acid methyl ester;4-Pyridinecarboxylic acid, 2-Methyl-, Methyl ester;4-Pyridinecarboxylicacid,2-methyl-,methylester(9CI);2-methyl-4-Pyridinecarboxylic acid methyl ester (9CI ACI)
- CBNumber
- CB91095752
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 16830-24-3.mol
2-methyl-4-pyridinecarboxylic acid methyl ester Property
- Boiling point:
- 108-110 °C(Press: 19 Torr)
- Density
- 1.104±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 3.84±0.10(Predicted)
- Appearance
- Yellow to brown Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M779610
- Product name
- Methyl2-Methylisonicotinicacid
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR954067
- Product name
- Methyl2-methylisonicotinate
- Purity
- 97%
- Packaging
- 1g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- 8594AA
- Product name
- Methyl2-methylisonicotinate
- Packaging
- 25g
- Price
- $477
- Updated
- 2021/12/16
- Product number
- CHM0092564
- Product name
- METHYL 2-METHYLISONICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $719.17
- Updated
- 2021/12/16
- Product number
- CHM0092564
- Product name
- METHYL 2-METHYLISONICOTINIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1101.18
- Updated
- 2021/12/16
2-methyl-4-pyridinecarboxylic acid methyl ester Chemical Properties,Usage,Production
Synthesis
3998-90-1
16830-24-3
Methyl 2-chloro-6-methylpyridine-4-carboxylate (15.0 g, 80.8 mmol) was added with 10% palladium carbon catalyst (50% water, 5.00 g) and triethylamine (22.5 mL, 162 mmol) in N,N-dimethylformamide (200 mL). The reaction was stirred for 15 hours at room temperature under hydrogen atmosphere. After completion of the reaction, the catalyst was removed by filtration and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography with the eluent ethyl acetate:methanol (100:0 to 50:1) to afford methyl 2-methylpyridine-4-carboxylate (14.8 g, 61% yield) as an oil.1H NMR (CDCl3) δ: 2.64 (3H, s), 3.95 (3H, s), 7.64 (1H, dd, J = 5.2, 0.8 Hz), 7.72 (1H, s), 8.65 (1H, d, J = 4.7 Hz).
References
[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 3, p. 647 - 660
[2] Patent: US5962458, 1999, A
[3] Patent: US6362336, 2002, B1. Location in patent: Example 63
[4] Helvetica Chimica Acta, 1955, vol. 38, p. 1046,1058
[5] Bulletin de la Societe Chimique de France, 1958, p. 687,691