Erythrodiol Property

Melting point:

230-231 °C(lit.)

Boiling point:

520.5±50.0 °C(Predicted)

Density 

1.05±0.1 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly, Sonicated), Methanol (Slightly)

pka

15.09±0.10(Predicted)

form 

Solid

color 

White to Off-White

Water Solubility 

insoluble in water

BRN 

2340203

LogP

9.180 (est)

CAS DataBase Reference

545-48-2(CAS DataBase Reference)

Safety

Risk Statements 

22

Safety Statements 

2-45

WGK Germany 

3

F 

10-23

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

Erythrodiol Chemical Properties,Usage,Production

Description

Erythrodiol is a triterpene that has been found in olive oil and has diverse biological activities. It induces relaxation of isolated rat aortic rings precontracted with phenylephrine (EC₅₀ = 3.38 μM). Erythrodiol inhibits the growth of HT-29 adenocarcinoma cells (EC₅₀ = 48.8 μM). It induces production of reactive oxygen species (ROS) and apoptosis in MCF-7 cells when used at a concentration of 100 μM. Topical administration of erythrodiol (0.5 mg/ear) reduces ear edema and myeloperoxidase (MPO) activity induced by phorbol 12-myristate 13-acetate (TPA; ) in mice.

Uses

It is an essential reagent in the synthesis of aminopropoxytriterpenoids that have anticancer activity. 3β-Erythrodiol has pharmacological property as a vasodilatory agent. It may have interesting therapeutic potential as a new vasodilator drug, for protecting the cardiovascular system.

Definition

ChEBI: Erythrodiol is a pentacyclic triterpenoid that is beta-amyrin in which one of the hydrogens of the methyl group at position 28 has been replaced by a hydroxy group. It is a plant metabolite found in olive oil as well as in Rhododendron ferrugineum and other Rhododendron species. It has a role as a plant metabolite. It is a pentacyclic triterpenoid, a primary alcohol, a secondary alcohol and a diol. It is functionally related to a beta-amyrin.