ChemicalBook > CAS DataBase List > Sodium danshensu

Sodium danshensu

Product Name: Sodium danshensu
CAS No.: 67920-52-9
Chemical Name: Sodium danshensu
Synonyms: NSC122009;NCI-C02120;NSC 122009;NSC-122009;dium danshensu;Sodium danshensu;DANSHENSU SODIUM (RG);Salvianic acid A sodium;(±)-DanShenSu sodium sal;Salvia natriuretic peptide
CBNumber: CB91117913
Molecular Formula: C9H11NaO5
Formula Weight: 222.17
MOL File: 67920-52-9.mol

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Sodium danshensu Property

storage temp.: Inert atmosphere,2-8°C
solubility: H2O : 100 mg/mL (454.24 mM; Need ultrasonic)DMSO : 100 mg/mL (454.24 mM; Need ultrasonic)
form: powder
color: White-beige
InChI: InChI=1S/C9H10O5.Na.H/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;;/h1-3,8,10-12H,4H2,(H,13,14);;
InChIKey: UPKQTJGQYNOELB-UHFFFAOYSA-N
SMILES: C(C1C=CC(O)=C(O)C=1)C(O)C(=O)O.[NaH]

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 24/25
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27222
Product name: Danshensu (sodium salt)
Packaging: 25mg
Price: $79
Updated: 2024/03/01

Cayman Chemical

Product number: 27222
Product name: Danshensu (sodium salt)
Packaging: 100mg
Price: $264
Updated: 2024/03/01

Cayman Chemical

Product number: 27222
Product name: Danshensu (sodium salt)
Packaging: 10mg
Price: $34
Updated: 2024/03/01

Cayman Chemical

Product number: 27222
Product name: Danshensu (sodium salt)
Packaging: 50mg
Price: $141
Updated: 2024/03/01

Usbiological

Product number: 300987
Product name: Sodium Danshensu
Packaging: 20mg
Price: $280
Updated: 2021/12/16

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Sodium danshensu Chemical Properties,Usage,Production

Description

Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities. It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury. Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction. It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model. Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.

Chemical Properties

White to light brown powder

Uses

Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain.

in vivo

Salvianic acid A (3 or 10 mg/kg, p.o., once daily for 6 weeks) suppresses inflammatory reactions and inhibits oxidative stress in atherosclerosis (AS) rats induced by a high-fat diet, showing protective effects against atherosclerosis^[5].

Animal Model:	Atherosclerosis (AS) model induced by a high-fat diet in Sprague-Dawley rats (180-220 g)^[4]
Dosage:	3 or 10 mg/kg
Administration:	Oral gavage (p.o.), once daily for 6 weeks
Result:	Inhibited atherosclerotic lesion progression and reduced aortic lipid deposition by 58.2% and 72.8% in high-fat diet-induced AS rats. Improved lipid profiles by lowering triglyceri/brdes, total cholesterol, and LDL cholesterol while significantly increasing HDL cholesterol in AS rats. Enhanced antioxidant enzyme activity, upregulated the Nrf2/HO-1 pathway, and reduced the expression of p47phox and p22phox.

target

Calcium Channel | Potassium Channel | Akt | GSK-3 | Bcl-2/Bax | PI3K

References

[1] GUANWEI FAN. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 10: 1908-1919. DOI: 10.1111/jcmm.12883
[2] YING YIN . Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis[J]. European journal of pharmacology, 2017, 814: Pages 274-282. DOI: 10.1016/j.ejphar.2017.08.035
[3] HONG-YING CAO. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice.[J]. Oncology Letters, 2017, 13 2: 605-612. DOI: 10.3892/ol.2016.5508
[4] HANG XU. Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats.[J]. Oncotarget, 2017, 8 70: 115434-115443. DOI: 10.18632/oncotarget.23272

Sodium danshensu Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium danshensu Suppliers

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View Lastest Price from Sodium danshensu manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Sodium Danshensu 67920-52-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-08

Shanghai Standard Technology Co., Ltd.

Product: Sodium Danshensu 67920-52-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-08

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Sodium Danshensu 67920-52-9 67920-52-9
Price: US $65.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-10

67920-52-9, Sodium danshensuRelated Search:

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3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt

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3,4-Dihydroxyphenyl-.alpha.-hydroxypropanoic acid sodiuM salt

Sodium DL-beta-(3,4-dihydroxyphenyl)lactate

Sodium danshensu

Sodium 3-(3,4-dihydroxyphenyl)lactate

DANSHENSU SODIUM (RG)

Salvia natriuretic peptide

sodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate

Sodium 3-(3,4-dihydroxyphenyl)-DL-lactate

α,3,4-Trihydroxybenzenepropanoic acid sodium salt

dium danshensu

Salvianic acid A sodium

Sodium 3-(3,4-dihydroxyphenyl)lactate, 98%, from Salvia miltiorrhiza Bge.

Benzenepropanoic acid, a,3,4-trihydroxy-, sodium salt(1:1)

sodium D-(+)-β-(3,4-dihydroxyphenyl)lactate

Sodium Danshensu 67920-52-9

(±)-DanShenSu sodium sal

Salvianic acid A sodium,HPLC≥98%

Benzenepropanoic acid, a,3,4-trihydroxy-, monosodium salt

NCI-C02120

NSC 122009

NSC122009

NSC-122009

Benzenepropanoic acid, α,3,4-trihydroxy-, sodium salt (1:1)

alpha,3,4-Trihydroxy-benzenepropanoic acid sodium salt

3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate

Sodium Danshensu|||(±)-DanShenSu sodium salt|||(±)-DanShenSu sodium sal

3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid, sodium salt

3-(3`,4`-Dihydroxyphenyl)lactic acid sodium salt-RM

Danshensu sodium salt, 10 mM in DMSO

(Rac)-Salvianic acid A (sodium)

67920-52-9

C9H10O5Na

C9H9NaO5

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract