Bindarit

Product Name: Bindarit
CAS No.: 130641-38-2
Chemical Name: Bindarit
Synonyms: AF 2838;CS-1989;indarit;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;Bindarit, 10 mM in DMSO;Bindarit, CCL2, CCL7 and CCL8 inhibitor;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid
CBNumber: CB91118288
Molecular Formula: C19H20N2O3
Formula Weight: 324.37
MOL File: 130641-38-2.mol

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Bindarit Property

Boiling point:: 542.9±40.0 °C(Predicted)
Density: 1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form: A crystalline solid
pka: 3.59±0.10(Predicted)
color: White to off-white
InChI: InChI=1S/C19H20N2O3/c1-19(2,18(22)23)24-13-16-15-10-6-7-11-17(15)21(20-16)12-14-8-4-3-5-9-14/h3-11H,12-13H2,1-2H3,(H,22,23)
InChIKey: MTHORRSSURHQPZ-UHFFFAOYSA-N
SMILES: C(O)(=O)C(C)(OCC1C2=C(N(CC3=CC=CC=C3)N=1)C=CC=C2)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 5mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 25mg
Price: $250
Updated: 2024/03/01

Usbiological

Product number: 003975
Product name: Bindarit
Packaging: 5mg
Price: $460
Updated: 2021/12/16

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Bindarit Chemical Properties,Usage,Production

Description

Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC₅₀s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; K_i = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.

Uses

Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.

Uses

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

in vivo

Bindarit (50 mg/kg; oral administration; every day; for 4 months, 6 months, 8 months; NZB/W F1 female mice) delays the onset of proteinuria and significantly protects from renal function impairment. Bindarit completely prevents monocyte chemoattractant protein (MCP-1) up-regulation^[2].

Animal Model:	NZB/W F1 female mice ( two months of age)^[2]
Dosage:	50 mg/kg
Administration:	Oral administration; every day; for 4 months, 6 months, 8 months
Result:	Delayed the onset of proteinuria and significantly protected from renal function impairment.

References

[1] MASSIMILIANO MIROLO. Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.[J]. European cytokine network, 2008, 19 3: 119-122. DOI: 10.1684/ecn.2008.0133
[2] M SIRONI. A small synthetic molecule capable of preferentially inhibiting the production of the CC chemokine monocyte chemotactic protein-1.[J]. European cytokine network, 1999, 10 3: 437-442.
[3] EUGENIO MORA. Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.[J]. Cell Cycle, 2012, 11 1: 159-169. DOI: 10.4161/cc.11.1.18559
[4] CARLA ZOJA. Bindarit retards renal disease and prolongs survival in murine lupus autoimmune disease[J]. Kidney international, 1998, 53 3: Pages 726-734. DOI: 10.1046/j.1523-1755.1998.00804.x
[5] SHUJUN GE. The CCL2 synthesis inhibitor bindarit targets cells of the neurovascular unit, and suppresses experimental autoimmune encephalomyelitis.[J]. Journal of Neuroinflammation, 2012: 171. DOI: 10.1186/1742-2094-9-171
[6] YUYA FUTAGI . Identification of a selective inhibitor of human monocarboxylate transporter 4[J]. Biochemical and biophysical research communications, 2018, 495 1: Pages 427-432. DOI: 10.1016/j.bbrc.2017.10.025

Bindarit Preparation Products And Raw materials

Raw materials

Preparation Products

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Bindarit Suppliers

Canada 1 China 155 India 2 United Kingdom 2 United States 17 Global 177

Shanghai Synchem Pharma Co., ltd

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Tetranov Biopharm

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Hangzhou Sage Chemical Co., Ltd.

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NCE Biomedical Co.,Ltd.

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130641-38-2, BindaritRelated Search:

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Bindarit

Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-

2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid

AF 2838

2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid

AF2838;AF-2838;AF 2838

CS-1989

2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid

Bindarit (AF2838)

indarit

Bindarit, CCL2, CCL7 and CCL8 inhibitor

Bindarit, 10 mM in DMSO

130641-38-2

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals