ChemicalBook > CAS DataBase List > Bindarit

Bindarit

Product Name
Bindarit
CAS No.
130641-38-2
Chemical Name
Bindarit
Synonyms
AF 2838;CS-1989;indarit;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;Bindarit, CCL2, CCL7 and CCL8 inhibitor;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid
CBNumber
CB91118288
Molecular Formula
C19H20N2O3
Formula Weight
324.37
MOL File
130641-38-2.mol
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Bindarit Property

Boiling point:
542.9±40.0 °C(Predicted)
Density 
1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
2-8°C
solubility 
DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form 
A crystalline solid
pka
3.59±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11479
Product name
Bindarit
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2024/03/01
Cayman Chemical
Product number
11479
Product name
Bindarit
Purity
≥98%
Packaging
5mg
Price
$88
Updated
2024/03/01
Cayman Chemical
Product number
11479
Product name
Bindarit
Purity
≥98%
Packaging
10mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
11479
Product name
Bindarit
Purity
≥98%
Packaging
25mg
Price
$250
Updated
2024/03/01
Usbiological
Product number
003975
Product name
Bindarit
Packaging
5mg
Price
$460
Updated
2021/12/16
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Bindarit Chemical Properties,Usage,Production

Description

Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC50s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; Ki = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.

Uses

Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.

Uses

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Bindarit Preparation Products And Raw materials

Raw materials

Preparation Products

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Bindarit Suppliers

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130641-38-2, BindaritRelated Search:

Imatinib Fasudil hydrochloride Dasatinib Avasimibe Entinostat Olaparib (1-METHYL-1H-INDAZOL-3-YL)METHANOL Bindarit 3-(HYDROXYMETHYL)INDAZOLE 3-METHYL-1H-INDAZOLE 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE 1-BENZYL-3-METHYL-1H-INDAZOLE

  • Bindarit
  • Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-
  • 2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid
  • AF 2838
  • 2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid
  • AF2838;AF-2838;AF 2838
  • CS-1989
  • 2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid
  • Bindarit (AF2838)
  • indarit
  • Bindarit, CCL2, CCL7 and CCL8 inhibitor
  • 130641-38-2
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals