Bindarit

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Product Name: Bindarit
CAS No.: 130641-38-2
Chemical Name: Bindarit
Synonyms: AF 2838;CS-1989;Bindarit;Bindarit (AF2838);AF2838;AF-2838;AF 2838;2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid;2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid;2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid;Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-
CBNumber: CB91118288
Molecular Formula: C19H20N2O3
Formula Weight: 324.37
MOL File: 130641-38-2.mol

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Bindarit Property

Boiling point:: 542.9±40.0 °C(Predicted)
Density: 1.18±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: DMSO:47.0(Max Conc. mg/mL);144.89(Max Conc. mM)
form: A crystalline solid
pka: 3.59±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 5mg
Price: $88
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 10mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 11479
Product name: Bindarit
Purity: ≥98%
Packaging: 25mg
Price: $250
Updated: 2024/03/01

Usbiological

Product number: 003975
Product name: Bindarit
Packaging: 5mg
Price: $460
Updated: 2021/12/16

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Bindarit Chemical Properties,Usage,Production

Description

Bindarit is an inhibitor of monocyte chemoattractant protein (MCP) production that is selective for MCP-1/CCL2, MPC-3/CCL7, and MCP-2/CCL8 over other chemokines. It inhibits LPS- or C. albicans-induced production of MCP-1/CCL2 in isolated human monocytes (IC₅₀s = 172 and 403 μM, respectively). Bindarit downregulates NF-κB signaling and prevents p65 and p65/p50-mediated MCP-1/CCL2 promoter activation in RAW264.7 cells. It delays the onset of proteinuria and prolongs survival in a mouse model of experimental lupus nephritis when administered at a dose of 50 mg/kg. It prevents LPS-induced increases in MCP-1/CCL2 expression in mouse brain and spinal cord when administered at a dose of 200 mg/kg and reduces the incidence and severity of experimental autoimmune encephalomyelitis (EAE) in mice. Bindarit is also a noncompetitive inhibitor of monocarboxylate transporter 4 (MCT4; K_i = 30.2 μM for the human transporter) that is selective for MCT4 over MCT1.

Uses

Bindarit shows anti-inflammatory activity due to a selective inhibition of a subfamily of inflammatory chemokines. Bindarit is a also protein antidenaturant agent. Bindarit modulates the NFkB pathway and has been shown to reduce secondary phase of adjuvant arthritis in rats.

Uses

Bindarit exhibits selective inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.

Bindarit Preparation Products And Raw materials

Raw materials

Preparation Products

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130641-38-2, BindaritRelated Search:

Imatinib Fasudil hydrochloride Dasatinib Avasimibe Entinostat Olaparib (1-METHYL-1H-INDAZOL-3-YL)METHANOL Bindarit 3-(HYDROXYMETHYL)INDAZOLE 3-METHYL-1H-INDAZOLE 1-BENZYL-3-HYDROXYMETHYL-1H-INDAZOLE 1-BENZYL-3-METHYL-1H-INDAZOLE

Bindarit

Propanoic acid, 2-Methyl-2-[[1-(phenylMethyl)-1H-indazol-3-yl]Methoxy]-

2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropionic acid

AF 2838

2-((1-Benzyl-1H-indazol-3-yl)Methoxy)-2-Methylpropanoic acid

AF2838;AF-2838;AF 2838

CS-1989

2-[(1-benzylindazol-3-yl)methoxy]-2-methylpropanoic acid

Bindarit (AF2838)

130641-38-2

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