Sodium phenylpyruvate

Product Name: Sodium phenylpyruvate
CAS No.: 114-76-1
Chemical Name: Sodium phenylpyruvate
Synonyms: SODIUM PHENYLPYRUVATE;sodium henylpyruvatep;Phenylpyruvate sodium;Phenylketonuria sodiuM;SodiuM Phenylpyruvate B-PHENYLPYRUVIC ACID SODIUM;Phenylpyruvic acid (sodium);SodiuM phenylpyruvate powder;PHENYLPYRUVIC ACID SODIUM SALT;SODIUM2-OXO-3-PHENYLPROPIONATE
CBNumber: CB9116557
Molecular Formula: C9H9NaO3
Formula Weight: 188.16
MOL File: 114-76-1.mol

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Sodium phenylpyruvate Property

Melting point:: >300 °C (lit.)
storage temp.: 2-8°C
form: powder
color: white
Water Solubility: Soluble in water
JECFA Number: 1479
BRN: 4770978
LogP: 0.54
CAS DataBase Reference: 114-76-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
HS Code: 2918300090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P8001
Product name: Sodium phenylpyruvate
Purity: powder
Packaging: 5g
Price: $71.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: P8001
Product name: Sodium phenylpyruvate
Purity: powder
Packaging: 25g
Price: $181
Updated: 2024/03/01

Alfa Aesar

Product number: H56767
Product name: Sodium phenylpyruvate, 98%
Packaging: 5g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: H56767
Product name: Sodium phenylpyruvate, 98%
Packaging: 25g
Price: $157.65
Updated: 2024/03/01

TRC

Product number: S667038
Product name: Sodium phenylpyruvate
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

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Sodium phenylpyruvate Chemical Properties,Usage,Production

Uses

Sodium phenylpyruvate is a substrate for phenylpyruvate decarboxylase and phenylpyruvate tautomerase.It inhibits amino acid formation and depresses oxygen consumption.

Uses

Phenylpyruvic acid, sodium salt is a substrate for phenylpyruvate decarboxylase and phenylpyruvate tautomerase.

Biological Activity

Sodium phenylpyruvate (Phenylpyruvic acid sodium salt) inhibits amino acid formation and depresses oxygen consumption.

Enzyme inhibitor

This aromatic a-keto acid and PKU biomarker (FWfree-acid = 164.16 g/mol; CAS 156-06-9 for acid; CAS 114-76-1 for sodium salt; CAS 51828-93-4 for calcium salt); lmax = 320 nm, e = 17500 M–1 cm–1 in 0.7 M NaOH), also known as 2-oxo-3-phenylpropanoic acid and a-oxohydrocinnamic acid, is readily formed by the action of a number of aminotransferases on phenylalanine. Phenylpyruvate is only slightly soluble in boiling water but is soluble in ethanol and diethyl ether. The solid oxidizes in air and decomposes on storage, if not dry. Sodium phenylpyruvate is a watersoluble monohydrate salt. Phenylketonuria: Phenylpyruvate is present at high urinary concentrations in phenylalanine monooxygenase deficiency, better known as Phenylketonuria. Indeed, individuals suffering PKU tend to excrete urine containing large quantities of phenyl-pyruvate, phenyl-acetate and phenyl-lactate, along with phenylalanine. If untreated, mental retardation and microcephaly are evident by the first year, along with irritability, epileptic seizures, and skin lesions. Target(s): acetolactate synthase; aldehyde reductase; apyrase; branched-chain a-keto acid dehydrogenase; [branched-chain a-keto-acid dehydrogenase] kinase, or [3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase; carnitine-acylcarnitine translocase; cathepsin D; choline acetyltransferase; 3-deoxy-7-phosphoheptulonate synthase, or 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase; dihydropteridine reductase; diphosphomevalonate decarboxylase; glutamate decarboxylase; glutamine:pyruvate aminotransferase; glycerate dehydrogenase, weakly inhibited; hexokinase (human brain), Ki = 2 mM; histidine decarboxylase; 4- hydroxyphenylpyruvate dioxygenase; 3a-hydroxysteroid dihydrogenase; 3b-hydroxysteroid dehydrogenase; hypothalamus acid proteinase; indolepyruvate decarboxylase, Ki = 50 μM; kynureninase; L-lactate dehydrogenase; L-lactate dehydrogenase (cytochrome); mercaptopyruvate sulfurtransferase; mevalonate-5-pyrophosphate decarboxylase; oxaloacetate tautomerase; phenylalanine ammonia-lyase; phenylalanyltRNA synthetase, weakly inhibited, Ki = 7.6 mM; pyruvate carboxylase; pyruvate decarboxylase; pyruvate dehydrogenase; pyruvate kinase (human), Ki = 8.5 mM; pyruvate oxidase; pyruvate transport; stearoyl-CoA 9-desaturase; tryptophan 2- monooxygenase; tryptophan 5-monooxygenase; tyrosinase; and tyrosine 2,3-aminomutase.

Purification Methods

The salt should have no OH broad bands in the IR at ~3000cm-1. If these are present, then they are due either to water contamination or to the presence of free acid. For the first case dry the solid thoroughly in a vacuum over P2O5, and in the latter case wash the salt well with Et2O in vacuo till free of acid. Alternatively add a slight excess of the free acid (cf p 332) in EtOH to ethanolic NaOH, evaporate to dryness and extract excess acid from the salt with dry Et2O. [Beilstein 10 I 325.]

Sodium phenylpyruvate Preparation Products And Raw materials

Raw materials

Preparation Products

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Sodium phenylpyruvate Suppliers

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View Lastest Price from Sodium phenylpyruvate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Sodium phenylpyruvate 114-76-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2023-01-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: Sodium phenylpyruvate 114-76-1
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.8%
Supply Ability: 100tons
Release date: 2024-08-23

Shandong Yanshuo Chemical Co., Ltd.

Product: sodium salt monohydrate 114-76-1
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: 1Tons
Release date: 2022-11-25

114-76-1, Sodium phenylpyruvateRelated Search:

Diclofenac sodium Sodium chlorite 4'-Methylpropiophenone Sodium pyruvate 3'-Hydroxypropiophenone Sodium carbonate Sodium bicarbonate Sodium hydroxide Sodium benzoate Sodium acetate 3-Phenylpyruvic acid Sodium chloride Sodium sulfate Sodium phenylpyruvate monohydrate ETHYL PHENYLPROPIOLATE 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT ETHYL-3-CYANO-3-PHENYLPYRUVATE 97 4-Hydroxyphenylpyruvic acid

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2-OXO-3-PHENYLPROPANOIC ACID SODIUM SALT

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SODIUM PHENYLPYRUVATE

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Sodium phenylpyruvate anhydrous

Benzenepropanoic acid, .alpha.-oxo-, sodium salt

SODIUM2-OXO-3-PHENYLPROPIONATE

sodium henylpyruvatep

2-Oxo-3-phenylpropanoic acid, Phenylpyruvic acid sodium salt

Sodium 2-oxo-3-phenylpropanoate

Phenylpyruvic acid sodium salt Sodium phenylpyruvate α-Ketophenylalanine sodium salt 2-Keto-3-phenylpropionic acid sodium salt 2-Oxo-3-phenylpropionic acid sodium salt

α-Oxobenzenepropanoic acid sodium salt

SodiuM Phenylpyruvate&nbsp

Phenylpyruvic Acid Sodium Salt Sodium 2-Oxo-3-phenylpropionate 2-Oxo-3-phenylpropionic Acid Sodium Salt

Benzenepropanoic acid, a-oxo-, sodiuM salt (1:1)

SodiuM phenylpyruvate powder

Phenylketonuria sodiuM

Phenylpyruvate sodium

2-Oxo-3-phenylpropionic acid sodium salt

SodiumPhenylpyruvateMonohydrate&gt

Benzenepropanoic acid, α-oxo-, sodium salt (1:1)

Phenylpyruvic acid sodium salt 1-hydrate

alpha-Oxo-benzenepropanoic acid sodium salt

Phenylpyruvic acid (sodium)

114-76-1

C9H7NaO3xH2O

C6H5CH2COCOONa

C6H5CH2COCO2Na

C9H7O3種a

C9H7NaO3

C9H7O3Na

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