ARG-GLY-ASP-SER

Product Name: ARG-GLY-ASP-SER
CAS No.: 91037-65-9
Chemical Name: ARG-GLY-ASP-SER
Synonyms: RGDS;RGDS peptide;ARG-GLY-ASP-SER;RGDS 1/2ACOH 2H2O;L-ARG-GLY-ASP-SER;Arg-Gly-Asp-Ser-OH;H-ARG-GLY-ASP-SER-OH;RGDS/ARG-GLY-ASP-SER;FIBRONECTIN INHIBITOR;Arg-Gly-Asp-Ser, >=98%
CBNumber: CB9117206
Molecular Formula: C15H27N7O8
Formula Weight: 433.42
MOL File: 91037-65-9.mol

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ARG-GLY-ASP-SER Property

Melting point:: 183-187℃
Density: 1.65±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: ≥21.65 mg/mL in H2O; insoluble in EtOH; insoluble in DMSO
pka: 2.84±0.10(Predicted)
form: White to off-white powder
color: White to off-white
Water Solubility: Soluble in water at 1mg/ml
Sequence: H-Arg-Gly-Asp-Ser-OH

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9041
Product name: Arg-Gly-Asp-Ser
Purity: ≥95% (HPLC)
Packaging: 2mg
Price: $82.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 03-34-0002
Product name: H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem
Packaging: 25mg
Price: $210
Updated: 2024/03/01

Alfa Aesar

Product number: J64877
Product name: Arg-Gly-Asp-Ser
Packaging: 5mg
Price: $85.2
Updated: 2023/06/20

Cayman Chemical

Product number: 15359
Product name: RGDS Peptide
Purity: ≥95%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 15359
Product name: RGDS Peptide
Purity: ≥95%
Packaging: 10mg
Price: $73
Updated: 2024/03/01

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ARG-GLY-ASP-SER Chemical Properties,Usage,Production

Uses

Supports fibroblast attachment

Uses

Arg-Gly-Asp-Ser has been used:

to study its effects on cell attachment in rats
to analyse the interaction of fibrinogen with erythrocytes occurs through integrin related receptor
to pretreat the cells, to assess the role of integrin in the cell attachment process
to test its competition with platelet-secreted, nanosheet-adsorbed proteins for binding to glycoprotein IIIa (GPIIIa)

General Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRKcells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the λ receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.

RGDS has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor ?1 (TGF?1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated
to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages

Biological Activity

rgds peptide contains the rgd motif which is an antagonist of integrin [1, 2].integrins are cell-surface receptors that recognize rgd motifs present in various extracellular matrix proteins such as fibronectin, vitronectin, laminin, fibrinogen, von willebrand factor, osteopontin, thrombospondin, and collagen as well as in disintegrins. integrins activation triggers different signals regulating cell adhesion, migration, survival, apoptosis as well as processes such as angiogenesis, thrombosis and osteoporosis [1].in sk-mel-110 cells, rgds at 500 μg/ml significantly inhibited melanoma cells proliferation induced by human fibroblast growth factor-2 (fgf-2). furthermore, rgds treatment (48 h, 500 μg/ml) increased the percentage of cells in sub-g1-phase from 3% (with fgf-2 alone) to 13.2% (with fgf-2 and rgds), indicating that rgds might induce apoptosis in melanoma cells, in the presence of fgf-2 [1].in a guinea pig model of allergic asthma, topical treatment of the airways with intranasally instilled rgds (2.5 mm, 200 μl) attenuated allergen-induced airway smooth muscle hyperplasia and hypercontractility as well as increased pulmonary expression of smooth muscle myosin heavy chain and the proliferative marker proliferating cell nuclear antigen [2].[1]. aguzzi m s, fortugno p, giampietri c, et al. intracellular targets of rgds peptide in melanoma cells. molecular cancer, 2010, 9(84): 1-10.[2]. dekkers b g, bos i s, gosens r, et al. the integrin-blocking peptide rgds inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. american journal of respiratory and critical care medicine, 2010, 181(6): 556-565.

storage

Store at -20°C

ARG-GLY-ASP-SER Preparation Products And Raw materials

Raw materials

Preparation Products

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ARG-GLY-ASP-SER Suppliers

China 109 France 1 Germany 3 India 2 Japan 2 Switzerland 1 United Kingdom 6 United States 24 Global 148

MedChemexpress LLC

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View Lastest Price from ARG-GLY-ASP-SER manufacturers

Career Henan Chemical Co

Product: ARG-GLY-ASP-SER 91037-65-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-18

GenicBio Limited

Product: Arg-Gly-Asp-Ser
Price: US $1.00/MG
Min. Order: 5MG
Purity: >98%
Supply Ability: 5mg,10mg,25mg,100mg,1g,10g
Release date: 2018-07-29

91037-65-9, ARG-GLY-ASP-SERRelated Search:

Fibronectin tetrapeptide

L-Arginylglycyl-L-alpha-aspartyl-L-serine

L-Serine, L-arginylglycyl-L-alpha-aspartyl-

L-Serine, N-(N-(N-L-arginylglycyl)-L-alpha-aspartyl)-

arginyl-glycyl-aspartyl-serine

RGDS

RGDS 1/2ACOH 2H2O

L-Serine,N-[N-(N-L-arginylglycyl)-L-a-aspartyl]-

L-Serine,L-arginylglycyl-L-a-aspartyl-

Arg-Gly-Asp-Ser, >=98%

RGDS PEPTIDE;FIBRONECTIN INHIBITOR

H-Arg-Gly-Asp-Ser-OH - CAS 91037-65-9 - Calbiochem

Arg-Gly-Asp-Ser, ≥95%(HPLC)

L-ARG-GLY-ASP-SER

H-ARG-GLY-ASP-SER-OH

FIBRONECTIN ATTACHMENT PEPTIDE

FIBRONECTIN INHIBITOR

ARG-GLY-ASP-SER

ARG-GLY-ASP-SER 1/2ACOH 2H2O

RGDS/ARG-GLY-ASP-SER

Arg-Gly-Asp-Ser-OH

L-Arg-Gly-L-Asp-L-Ser-OH

RGDS peptide

L-Serine, L-arginylglycyl-L-α-aspartyl-

91037-65-9

C15H27N7O8

Extracellular Matrix Peptides and Proteins

Extracellular Matrix

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Cytoskeleton and Extracellular Matrix

Peptide

Cell Signaling Enzymes

ECM ProteinsCytoskeleton and Extracellular Matrix

Extracellular Matrix

Extracellular Matrix Peptides (ECM)

Extracellular Matrix Peptides and ProteinsPeptides for Cell Biology

Fibronectin Fragments and Analogs

Matrix Metalloproteinases Products

Various Peptides

RGD