ChemicalBook > CAS DataBase List > Liarozole

Liarozole

Product Name: Liarozole
CAS No.: 115575-11-6
Chemical Name: Liarozole
Synonyms: Liarozole;Liarozole, 10 mM in DMSO;1H-Benzimidazole, 6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-;6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole;Retinoic acid receptors,Mesenchymal,R 75251,RAR/RXR,CYPs,Retinoid X receptors,R-75251,Imidazole,Ovariectomized,R75251,MCF-7,Liarozole,Cytochrome P450,Inhibitor,inhibit,SCID,Hydroxylation
CBNumber: CB91179041
Molecular Formula: C17H13ClN4
Formula Weight: 308.76
MOL File: 115575-11-6.mol

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Liarozole Property

Melting point:: 108.2°
Boiling point:: 578.2±40.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
solubility: DMSO: soluble
form: A solid
pka: 12.36±0.10(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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Liarozole Chemical Properties,Usage,Production

Uses

Antipsoriatic.

Definition

ChEBI: Liarozole is a member of benzimidazoles.

brand name

Liazal(Janssen).

in vivo

Liarozole (5-20 mg/kg; p.o.; 3 days) reverses the vaginal keratosis caused by estrogen stimulation^[5].
Liarozole (40 mg/kg; p.o.; 21 days) reduces tumor burden substantially^[6].

Animal Model:	Ovariectomized rats^[5]
Dosage:	5~20 mg/kg
Administration:	P.o.; 3 days
Result:	Reversed the vaginal keratosis caused by estrogen stimulation.

Animal Model:	SCID mice^[6]
Dosage:	40 mg/kg
Administration:	P.o.; 21 days
Result:	Inhibited tumor growth and survival.

IC 50

CYP26: 7 μM (IC₅₀)

Liarozole Preparation Products And Raw materials

Raw materials

Preparation Products

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Liarozole Suppliers

China 32 India 1 United States 5 Global 38

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115575-11-6, LiarozoleRelated Search:

5-[(3-CHLOROPHENYL)-1H-IMIDAZOL-1-YLMETHYL]-1H-BENZIMIDAZOLE HYDROCHLORIDE 1H-Benzimidazole,5-(1H-imidazol-1-ylmethyl)-(9CI) Liarozole (3-chlorophenyl)(phenyl)methylamine Pentetrazol Astemizole Anastrozole Alfuzosin

Liarozole

6-((3-chlorophenyl)(1H-imidazol-1-yl)methyl)-1H-benzo[d]imidazole

1H-Benzimidazole, 6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-

Retinoic acid receptors,Mesenchymal,R 75251,RAR/RXR,CYPs,Retinoid X receptors,R-75251,Imidazole,Ovariectomized,R75251,MCF-7,Liarozole,Cytochrome P450,Inhibitor,inhibit,SCID,Hydroxylation

Liarozole, 10 mM in DMSO

115575-11-6