ChemicalBook > CAS DataBase List > 1,3-Dimethylbarbituric acid

1,3-Dimethylbarbituric acid

Product Name
1,3-Dimethylbarbituric acid
CAS No.
769-42-6
Chemical Name
1,3-Dimethylbarbituric acid
Synonyms
1,3-DIMETHYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE;1,3-DiMethyl-;1,3-Dimethylbarbituric;2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-;6(1H;AKOS B029702;Uradil impurity 19;1,3-Dimethylbarbitur;Dimethylbarbituric acid;1,3-dimethylbarbiturates
CBNumber
CB9121414
Molecular Formula
C6H8N2O3
Formula Weight
156.14
MOL File
769-42-6.mol
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1,3-Dimethylbarbituric acid Property

Melting point:
121-123 °C (lit.) 121-123 °C
Boiling point:
228.1±23.0 °C(Predicted)
Density 
1.322±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
hot water: soluble0.5g/10 mL, clear, colorless to faintly yellow
form 
Crystalline Powder
pka
pK1:4.68(+1) (25°C)
color 
White/cream/pale yellow
Water Solubility 
Soluble in water.
BRN 
139810
CAS DataBase Reference
769-42-6(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dimethylbarbituric acid(769-42-6)
EPA Substance Registry System
2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl- (769-42-6)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-36/39
WGK Germany 
3
TSCA 
Yes
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
39565
Product name
1,3-Dimethylbarbituric acid
Purity
≥99.0% (T)
Packaging
50g
Price
$88.9
Updated
2024/03/01
Sigma-Aldrich
Product number
39565
Product name
1,3-Dimethylbarbituric acid
Purity
≥99.0% (T)
Packaging
250g
Price
$219
Updated
2024/03/01
TRC
Product number
D463650
Product name
1,3-Dimethylbarbituric acid
Packaging
25g
Price
$2240
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK127134
Product name
1,3-Dimethylbarbituric acid
Purity
98%
Packaging
500g
Price
$178
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0017293
Product name
1,3-DIMETHYLBARBITURIC ACID
Purity
95.00%
Packaging
1G
Price
$750.75
Updated
2021/12/16
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1,3-Dimethylbarbituric acid Chemical Properties,Usage,Production

Chemical Properties

Yellow or brownish powder

Uses

1,3-Dimethylbarbituric acid is used as a catalyst in the Knoevenagel condensation of a series of aromatic aldehydes. It is also used in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives and enantioselective synthesis of isochromene pyrimidinedione derivatives.

Uses

1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid. All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position.

General Description

1,3-Dimethylbarbituric acid (1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione) is an active methylene compound. It undergoes hollow Pd6 water-soluble cage, [{(tmen)Pd}6(timb)4](NO3)12 (tmen= N,N,N′,N′-tetramethylethylenediamine, timb=1,3,5-tris(1-imidazolyl)benzene)-catalyzed Knoevenagel condensation reaction with pyrene-1-carboxaldehyde. It undergoes self-sorted Pd7 molecular boat having an internal nanocavity (catalyst)-assisted Knoevenagel condensation reaction with various aromatic aldehydes. It has been synthesized by reacting 1,3-dimethylurea, malonic acid and acetic anhydride in acetic acid. It is widely used for the synthesis of various synthetic intermediates and heterocyclic compounds.

Purification Methods

Crystallise the acid from water and sublime it in a vacuum. Also purify it by dissolving 10g in 100mL of boiling CCl4/CHCl3 (8:2) (1g charcoal), filtering and cooling to 25o. Dry it in vacuo [Kohn et al. Anal Chem 58 3184 1986]. [Beilstein 24 III/IV 1875.]

1,3-Dimethylbarbituric acid Preparation Products And Raw materials

Raw materials

Preparation Products

6-[N-(2-Hydroxyethyl)amino]-1,3-dimethyl-2,4(1H,3H)-dione
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1,3-Dimethylbarbituric acid Suppliers

Belgium 1 China 315 Europe 3 France 2 Germany 6 India 23 Japan 2 Russia 2 Slovakia 1 South Korea 1 Switzerland 1 The Netherlands 2 Ukraine 1 United Kingdom 8 United States 27 Global 395
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
Chemische Fabrik Berg GmbH
Tel
--
Fax
--
Email
contact@cfb.de
Country
Germany
ProdList
34
Advantage
58
Chemische Fabrik Berg GmbH (CFB)
Tel
--
Fax
--
Email
kontakt@cfb.de
Country
Germany
ProdList
21
Advantage
58
Klaus F. Meyer GmbH
Tel
--
Fax
--
Email
cinfoc@klausfmeyer.de
Country
Germany
ProdList
271
Advantage
64
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from 1,3-Dimethylbarbituric acid manufacturers

Jinan Finer Chemical Co., Ltd
Product
1,3-Dimethylbarbituric acid 769-42-6
Price
US $22.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100mt
Release date
2024-12-25
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
1,3-Dimethylbarbituric acid 769-42-6
Price
US $1000.00-400.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-12
Shandong Huizhihan Supply Chain Co., Ltd
Product
1,3-Dimethylbarbituric acid 769-42-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20Tons
Release date
2024-12-11

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