Halofuginone hydrobromide
regulation- Product Name
- Halofuginone hydrobromide
- CAS No.
- 64924-67-0
- Chemical Name
- Halofuginone hydrobromide
- Synonyms
- STENOROL;Ru-19110;Tempostatin;RU-19110(HBr);CID 121225393;Unii-ptc2969mv1;55837-20-2 (free);RU-19110 (hydrobromide);HALOFUGINONEHYDROBROMIDE;Haloperidone hydrobromide
- CBNumber
- CB91230111
- Molecular Formula
- C16H17BrClN3O3.HBr
- Formula Weight
- 495.59
- MOL File
- 64924-67-0.mol
Halofuginone hydrobromide Property
- Melting point:
- 247° (dec)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO.
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P262Do not get in eyes, on skin, or on clothing.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 32481
- Product name
- Halofuginone hydrobromide
- Purity
- VETRANAL?, analytical standard
- Packaging
- 10mg
- Price
- $513
- Updated
- 2024/03/01
- Product number
- 1993
- Product name
- Halofuginone hydrobromide
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $128
- Updated
- 2021/12/16
- Product number
- H102490
- Product name
- Halofuginone hydrobromide
- Packaging
- 1mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- H102490
- Product name
- Halofuginone hydrobromide
- Packaging
- 2mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- FH23731
- Product name
- Halofuginone hydrobromide
- Packaging
- 500mg
- Price
- $200
- Updated
- 2021/12/16
Halofuginone hydrobromide Chemical Properties,Usage,Production
regulation
Halofuginone hydrobromide is included in the European Union Register of Feed Additives pursuant to Regulation (EC) No 1831/2003 and is authorized for use in chickens for fattening and turkeys (maximum age 12 weeks) at a dose range of 2–3 mg/kg complete feedingstuffs with a withdrawal time of 5 days[1]. The European Food Safety Authority (EFSA) issued an opinion on the coccidiostat STENOROL® containing 0.6% halofuginone hydrobromide for chickens for fattening and turkeys (EFSA, 2003).
Description
Halofuginone hydrobromide (Halofuginone) is a specific collagen Type I inhibitor that antagonize or inhibit the development of new blood vessels, hence can prevent intimal hyperplasia at a vascular anastomosis. It is used in the treatment or prevention of coccidiosis in both humans and animals.
Chemical Properties
White to Off-White Solid
Uses
Halogenated derivative of Febrifugine. Halofuginone hydrobromide is used as an antiprotozoal (coccidiostat).
Definition
The hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibro-proliferative diseases.
Biological Activity
Halofuginone hydrobromide is a high affinity competitive prolyl-tRNA synthetase inhibitor (Ki = 18.3 nM). Blocks expression of MMP2. Inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway. Also antiparasitic.
Toxicology
Halofuginone HBr (Halofuginone hydrobromide) is toxic by inhalation, dermal and ocular routes and is very irritant to both the eye and the skin. It is considered also a skin sensitiser[1].
storage
Store at -20°C
Mode of action
Halofuginone is an an ATP-dependent inhibitor prolyl-tRNA synthetase (Ki of 18.3 nM). Halofuginone attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Blocks expression of MMP2 and inhibits ECM invasion in vitro and lung metastasis by bladder cancer cells in mice. Also inhibits the development of Th17-driven autoimmunity in a mouse model of multiple sclerosis by activating the amino acid response (AAR) pathway.
References
[1] Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, et al. “Safety of a feed additive consisting of halofuginone hydrobromide (STENOROL?) for chickens for fattening and turkeys (Huvepharma N.V.).” EFSA Journal 20 12 (2022).
Halofuginone hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
Halofuginone hydrobromide Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
- Tel
- --
- Fax
- --
- cms.marketing@cms-chemicals.com
- Country
- United Kingdom
- ProdList
- 3708
- Advantage
- 60
View Lastest Price from Halofuginone hydrobromide manufacturers
- Product
- Halofuginone hydrobromide 64924-67-0
- Price
- US $10.00/kg
- Min. Order
- 25kg
- Purity
- 99%
- Supply Ability
- 10000kg /year
- Release date
- 2023-11-01
- Product
- Halofuginone Hydrobromide 64924-67-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Halofuginone Hydrobromide 64924-67-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09