FK-3311
- Product Name
- FK-3311
- CAS No.
- 116686-15-8
- Chemical Name
- FK-3311
- Synonyms
- FK-3311;CS-1073;FK-3311 ，S2595;FK-3311; FK3311;COX-2 Inhibitor V;FK 3311, 10 mM in DMSO;COX-2 Inhibitor V, FK3311;COX,Cyclooxygenase,Inhibitor,inhibit,FK 3311,FK3311;N-[4-Acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide;Methanesulfonamide, N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]-
- CBNumber
- CB91247805
- Molecular Formula
- C15H13F2NO4S
- Formula Weight
- 341.33
- MOL File
- 116686-15-8.mol
FK-3311 Property
- Boiling point:
- 431.3±55.0 °C(Predicted)
- Density
- 1.419±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble in DMSO
- form
- White solid
- pka
- 6.82±0.10(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- 236015
- Product name
- COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem
- Packaging
- 5mg
- Price
- $266
- Updated
- 2025/07/31
- Product number
- 17697
- Product name
- FK-3311
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 17697
- Product name
- FK-3311
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 17697
- Product name
- FK-3311
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 17697
- Product name
- FK-3311
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
FK-3311 Chemical Properties,Usage,Production
Uses
COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID.
Biological Activity
Cyclooxygenase-2 (COX-2) inhibitor. Inhibits zymosan-induced prostaglandin E 2 production by rat peritoneal neutrophils in vitro and adjuvant-induced arthritis in vivo . Anti-inflammatory.
in vivo
L-PVR, CO, PaO(2), and WDR were significantly better in the FK group than in the control group. Histological tissue edema was mild, and PMN infiltration was significantly reduced in the FK group compared to the control group. The serum TxB(2) levels were significantly lower in the FK group than in the control group, while 6-keto-PGF(1alpha) levels were not significantly reduced. Two-day survival rate was significantly better in the FK group than in the control group[2].
Survival rate was significantly better and serum GOT levels 30 min after reperfusion were significantly lower in the FK high-dose group compared to the other two groups. Four hours after reperfusion, GPT levels and liver tissue flow were significantly better in the FK high-dose group compared to the control. Both 30 min and 4 hr after reperfusion, serum TxB(2) levels were significantly lower in the FK high-dose group compared to the control[3].
IC 50
COX-2
FK-3311 Preparation Products And Raw materials
Raw materials
Preparation Products
FK-3311 Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77
View Lastest Price from FK-3311 manufacturers
- Product
- N-[4-acetyl-2-(2,4-difluorophenoxy)phenyl]methanesulfonamide 116686-15-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30