description Limonoid compounds Physical and chemical properties Pharmacological effects Clinical application Uses
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Limonin

description Limonoid compounds Physical and chemical properties Pharmacological effects Clinical application Uses
Product Name
Limonin
CAS No.
1180-71-8
Chemical Name
Limonin
Synonyms
EVODIN;LiMone;Lemonin;LIMONIN;LIMONINE;NSC 36508;LIMONIN(P);LIMONIN(RG);Limonin >CITROLIMONIN
CBNumber
CB9125063
Molecular Formula
C26H30O8
Formula Weight
470.51
MOL File
1180-71-8.mol
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Limonin Property

Melting point:
298 C
alpha 
D -128° (c = 1.21 in acetone)
Boiling point:
67 °C
Density 
1.39±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Sparingly)
color 
White to Off-White
λmax
285nm(lit.)
Merck 
14,5494
LogP
0.474 (est)
EPA Substance Registry System
Limonin (1180-71-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36-24/25
WGK Germany 
3
RTECS 
RR1122000
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L9647
Product name
Limonin
Purity
from citrus seeds, >90% (HPLC)
Packaging
5mg
Price
$226
Updated
2024/03/01
Sigma-Aldrich
Product number
64081
Product name
Limonin
Purity
analytical standard
Packaging
10mg
Price
$551
Updated
2022/05/15
TCI Chemical
Product number
L0258
Product name
Limonin
Purity
>95.0%(HPLC)
Packaging
100mg
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
L0258
Product name
Limonin
Purity
>95.0%(HPLC)
Packaging
1g
Price
$281
Updated
2024/03/01
Cayman Chemical
Product number
16932
Product name
Limonin
Purity
≥98%
Packaging
50mg
Price
$57
Updated
2024/03/01
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Limonin Chemical Properties,Usage,Production

description

Limonin is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability. Limonin is a phytonutrient found in most citrus fruits. Natural sources of limonin include oranges, grapefruits, lemons, and limes. Within the fruit it is attached to a sugar and the combined molecule is called limonin glucoside.Limonin is what remains after our bodies cleave a glucose, or sugar molecule, from limonin's parent compound, limonin glucoside. Limonin glucoside is present in citrus and citrus juices in about the same amount as vitamin C.

The good news is limonin has shown to have exceptional health benefits in humans and other animals. It seems to be able to help reduce the development and growth of cancers. It also has the effect of lowering cholesterol in the blood stream.

In 2000, Manners, Hasegawa, and their Canadian co-authors reported that limonin may be among the citrus-juice compounds that lower cholesterol. In lab tests, they found that human liver cells produced less apo B—a compound associated with higher cholesterol levels—when exposed to limonin.

Limonoid compounds

Limonoid is a kind of triterpenoid derivatives widely distributed in Rutaceae and Meliaceae. They are one of the bitter components of citrus juice, presented in the form of glucose derivatives in mature fruits. Plant seed is the main source of these compounds aglycones and glucoside with grape seeds containing the highest content. It has been measured of 15 kinds of commercial orange juice samples, the average citric acid concentration was (320 ± 48) mg/kg while the value for 8 kinds of grape juices is (190±36) mg/kg and for four kinds of lemon juices is (83 ± 10) Mg/kg. Citrus juice has a very low aglycone content, generally being only about 2mg/kg (Hasegawa 1994).
The molecular structure of these compounds is that the D ring contains furan molecules, which can induce glutathione S-transferase. From the view of the effect of specific compound, the effect of limonin is not as strong as nomilin; the former one have no effect on this liver enzyme inactive while the latter one can induce the enzyme even at a concentration of as low as 5mg. Both of them have higher activity in the small intestine than in the liver. Norilin can inhibit the formation of benzo [a] pyrene-DNA adducts in the liver and target tissues and inhibit benzopyrene-induced lung cancer. In the mice trial, for the initial period, the effect of Norilin in inducing skin cancer through inhibiting DMBA is stronger than that of the limonin while the effect becomes weaker for the former one in the promotion phase. Other structurally related limonoids including Ichangin, isoobacunor C and berberine are also good inducers of glutathione-S-transferase (GST).
The above information was collected by Andy of Chemicalbook.

Physical and chemical properties

Limonin is a crystal with bitterness (dichloromethane + isopropanol or acetic acid). It is hard to be dissolved in water and ether, but being soluble in methanol, ethanol and acetic acid. Melting point 298 ° C, optical rotation-128 ° (c = 1.21, acetone).

The chemical structure of Limonin

Pharmacological effects

Limonoids have various kinds of biological activities such as anti-tumor, insect antifeedant, anti-virus, analgesic, anti-inflammatory and hypnotic. The physiological activity of the limonoid analogues starts from the study of medicinal plants of the Rhodaceae family.
(1) Analgesic and anti-inflammatory effects
Studies have been conducted on the isolation of limonin from Evodiarutaecarpavar. bodinieri. People have also carried out corresponding study on its physiological effects. For example, experiments found that administration of 100 mg/kg limonene to mice can significantly reduce the number of mice of licking feet. At the same time, through the study on the effect of limonin analogue on the vascular permeability of acetic acid channels, bradykinin induced paw swelling reaction and arachidonic acid-induced ear edema, it was found that the product has significant analgesic and anti-Inflammatory effect.
 (2) Anti-anxiety sedation
The hypnotic test of anesthetized mice showed that limonoids such as limonin, nomilin, obarone, 7-aureprolone, 70r-limonol and other limonoids could prolong the sleep time of mice induced by the lithium-chlorine aldose and urethane, in which the compound, nomilin has a strong sedative effect.
(3) Pest control insecticidal activity
Regarding the ingestion inhibition effect of limonin analogues, the activity of the azadirachtin isolated from the seeds of A. zadirach ta indica is high and is effective against over 60 species of insects. Citrus limonin analogues (Auronium, Norilin and limonin) are also active against insects and termites. Development and utilization of these natural originated limonin analogs biological insecticides has great significance.
(4) Other effects
In addition to the above biological effects, it also have many other kinds of physiological effects such as antioxidant activity, antibacterial, inhibiting HIV, lowering cholesterol, significant diuretic effect, improving cardiovascular and cerebrovascular circulation and improving sleep, anti-virus, regulating cytochrome and so on, Of health care functions.

Clinical application

The study of limonin analogues was initiated for the purpose of removing them from citrus fruit in order to increase the value of the commodity. However, with the further deepened study on the physiological activities of limonoids, more and more attention has been paid to their recovery, refinement and application in citrus. Limonin analogues have physiological activity of inhibiting tumor growth and should be developed as functional food materials. After many years of research, Microherb has successfully isolated high purity 98% limonoids by advanced chromatographic separation technology, which is widely used in medicine, functional food supplements and biological pesticides.

Uses

It has antiproliferative and anti-apoptotic activity against several tumor cell lines and can inhibit the rat colon cancer induced by azoxymethane. By inhibiting the activity of HIV-1 protease, it inhibits the replication of HIV-1 virus in monocytes, macrophages and monocytes.

Chemical Properties

White powder

Uses

antiproliferative, antiviral, antiinflammatory, antinociceptive

Uses

Limonin is a limonoid extracted from various citrus plants. Bioactivity of Limonin have been revolved around its anti-HIV properties.

Uses

Limonin has been used:

  • to treat human peripheral blood mononuclear cells (PBMCs) to test its effect on human immunodeficiency virus (HIV) replication
  • to test its effects as an anti-osteoporosis agent in osteoblastogenesis activity in MC3T3-E1 cells and ovariectomized (OVX) rat model
  • as a reference standard in high-performance liquid chromatography (HPLC) system

Definition

ChEBI: Limonin is a limonoid, an epoxide, a hexacyclic triterpenoid, a member of furans, an organic heterohexacyclic compound and a lactone. It has a role as a metabolite, an inhibitor and a volatile oil component.

General Description

Limonin is a limonoid glycoside with cancer chemo-preventive activity.

Biochem/physiol Actions

Limonin is a triterpenoid aglycone that is a bitter principle of citrus fruits. It has anti-proliferative, proapoptotic activity on several cancer cell lines and inhibits azoxymethane-induced colon cancer in rats. It also inhibits HIV-1 replication in culturedf monocytes, macrophages, and mononuclear cells, perhaps by inhibition of HIV-1 protease activity.

Limonin Preparation Products And Raw materials

Raw materials

Preparation Products

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Limonin Suppliers

TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23662
Advantage
75
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View Lastest Price from Limonin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Limonin 1180-71-8
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min HPLC
Supply Ability
10KGS
Release date
2021-07-09
Shaanxi Haibo Biotechnology Co., Ltd
Product
Limonin 1180-71-8
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2000ton
Release date
2023-08-21
Hebei Yibangte Import and Export Co. , Ltd.
Product
Limonin 1180-71-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
50000kg
Release date
2023-08-30

1180-71-8, LimoninRelated Search:


  • LiMonin, froM TetradiuM ruticarpuM
  • LiMone
  • Evodia lactone
  • LiMonin SynonyMs LiMonoate D-ring-lactone
  • Lemon bitter
  • Lemonin
  • Evodine, 97.5%(HPLC)
  • (4aS,6aR,8aR,8bR,9aS,12S,12aS,14aR,14bR)-12-(3-Furyl)-6,6,8a,12a-tetramethyldecahydrooxireno[2,3-d]pyrano[4’,3’:3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(1H,6H,8aH)-trione
  • Limonin(Evodin)
  • EVODIN
  • CITROLIMONIN
  • DICTAMNOLACTONE
  • LIMONIN
  • LIMONINE
  • Limonoate D-ring-lactone
  • LIMONOIC ACID 3,19:16,17 DILACTONE
  • limonoic acid di-delta-lactone
  • OBACULACTONE
  • limonin from citrus seeds
  • 11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione,8-(3-furyl)decahydro-2,2,4a,8a-tetramethyl-
  • 11H,13H-Oxireno[d]pyrano[4',3':3,3a]isobenzofuro[5,4-f][2]benzopyran-4,6,13(2H,5aH)-trione,8-(3-furanyl)decahydro-2,2,4a,8a-tetramethyl-,(2aR,4aR,4bR,5aS,8S,8aS,10aR,10bR,14aS)-
  • Limonoic acid, di-δ-lactone
  • Limonin,Limonoate D-ring-lactone,Limonoic acid di-delta-lactone
  • 7,16-Dioxo-7,16-dideoxylimondiol
  • LIMONIN(P)(CALL)
  • LIMONIN(RG)
  • Limonin,Limonoic acid 3,19:16,17 dilactone
  • LIMONIN(P)
  • Limonin, 98%, from Evodia rutaecarpa (Juss.) Benth.
  • Limonin &gt
  • (4aS,6aR,8aR,8bR,9aS,12S,12aS,14aR,14bR)-12-(Furan-3-yl)-6,6,8a,12a-tetramethyldecahydrooxireno[2,3-d]pyrano[4',3':3,3a]isobenzofuro[5,4-f]isochromene-3,8,10(1H,6H,8aH)-trione
  • Limonin USP/EP/BP
  • NSC 36508
  • 1180-71-8
  • C26H30O8
  • Chemopreventive Agents
  • Cancer Research
  • Anti-proliferative Agents
  • BioChemical
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • CITRIMORE
  • Limonoids (Citrus, Bitter Compounds)
  • Natural Plant Extract
  • Nutritional Ingredients