dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate
- Product Name
- dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate
- CAS No.
- 21829-09-4
- Chemical Name
- dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate
- Synonyms
- Benidipine Impurity B;Benidipine Impurity 12;Calcium Channel antagonist 5;Divalproex Sodium Impurity 5;Nifedipine Impurity 1 (Benidipine Impurity 5);Benidipine Impurity 5 (Nifedipine Impurity 1);dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate;2,6-DIMETHYL-4-(4-NITRO-PH)-1,4-2H-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER;1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-, 3,5-dimethyl ester
- CBNumber
- CB91259211
- Molecular Formula
- C17H18N2O6
- Formula Weight
- 346.33
- MOL File
- 21829-09-4.mol
dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate Property
- Melting point:
- 165-168 °C
- Boiling point:
- 493.1±45.0 °C(Predicted)
- Density
- 1.271±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- Solid
- pka
- 2.62±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- R537454
- Product name
- 2,6-DIMETHYL-4-(4-NITRO-PH)-1,4-2H-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $30.7
- Updated
- 2025/07/31
- Product number
- R537454
- Product name
- 2,6-DIMETHYL-4-(4-NITRO-PH)-1,4-2H-PYRIDINE-3,5-DICARBOXYLIC ACID DIMETHYL ESTER
- Purity
- AldrichCPR
- Packaging
- 50MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- 0605CB
- Product name
- Dimethyl2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Packaging
- 100mg
- Price
- $126
- Updated
- 2021/12/16
- Product number
- 0605CB
- Product name
- Dimethyl2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Packaging
- 1g
- Price
- $293
- Updated
- 2021/12/16
- Product number
- A119433
- Product name
- Dimethyl2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $363
- Updated
- 2021/12/16
dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate Chemical Properties,Usage,Production
Uses
1,4-Dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester is used in a QSAR, diagnostic statistics and molecular modelling study among various substituted 1,?4-?dihydropyridine compounds as calcium channel antagonists.
Synthesis
555-16-8
105-45-3
21829-09-4
The general procedure for the synthesis of dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate from p-nitrobenzaldehyde and methyl acetoacetate was as follows: ammonium acetate (1 mmol) was added to a mixture of p-nitrobenzaldehyde (1 eq.) and methyl acetoacetate (1.1 eq.) in ethanol (1.5 mL) along with Er- MOF catalyst (20 mg). The reaction mixture was stirred at 70 °C for 4 hours. Upon completion of the reaction, the catalyst was removed by centrifugal separation. Subsequently, brine (5 mL) and ethyl acetate (5 mL) were added to the reaction mixture. The mixture was extracted with ethyl acetate and the organic phases were combined and washed sequentially with saturated aqueous NaHCO3 (10 mL) and brine (10 mL). The organic phase was dried over anhydrous Na2SO4 and concentrated under reduced pressure. After complete evaporation of the solvent under vacuum, the crude product was purified by column chromatography to afford the target compound dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. The experimental results showed that the Er-MOF catalyst could be recovered and reused five times without any significant decrease in the catalytic activity.
References
[1] Chemical Communications, 2011, vol. 47, # 32, p. 9230 - 9232
[2] Tetrahedron Letters, 2010, vol. 51, # 8, p. 1187 - 1189
[3] Chemical Papers, 2011, vol. 65, # 6, p. 898 - 902
[4] Catalysis Letters, 2017, vol. 147, # 2, p. 453 - 462
[5] Patent: CN107141249, 2017, A. Location in patent: Paragraph 0130; 0131
dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate Preparation Products And Raw materials
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View Lastest Price from dimethyl 2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3,5-dicarb oxylate manufacturers
- Product
- Nifedipine Impurity 1 21829-09-4
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-22