ChemicalBook > CAS DataBase List > Scopolamine butylbromide

Scopolamine butylbromide

Product Name
Scopolamine butylbromide
CAS No.
149-64-4
Chemical Name
Scopolamine butylbromide
Synonyms
HYOSCINE BUTYLBROMIDE;buscopan;HYOSCINE N-BUTYL BROMIDE;(1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide;buscol;scobro;donopon;joscine;scobron;Stibron
CBNumber
CB9126868
Molecular Formula
C21H30BrNO4
Formula Weight
440.37
MOL File
149-64-4.mol
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Scopolamine butylbromide Property

Melting point:
142-1440C
alpha 
D20 -20.8° (c = 3 in water)
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
optical activity
[α]25/D 20.8°, c = 3 in H2O(lit.)
CAS DataBase Reference
149-64-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
YM3500000
Toxicity
LD50 in mice (mg/kg): 15.6 i.v.; 74 i.p.; 570 s.c.; 3000 orally (Stockhaus, Wick)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7882
Product name
(?)-Scopolamine N-butyl bromide
Purity
≥98% (TLC), powder
Packaging
1g
Price
$54.7
Updated
2024/03/01
Sigma-Aldrich
Product number
S7882
Product name
(?)-Scopolamine N-butyl bromide
Purity
≥98% (TLC), powder
Packaging
5g
Price
$171
Updated
2024/03/01
Sigma-Aldrich
Product number
BP198
Product name
Hyoscine butylbromide
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$229
Updated
2024/03/01
Cayman Chemical
Product number
27223
Product name
Scopolamine N-butyl (bromide)
Packaging
1g
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
27223
Product name
Scopolamine N-butyl (bromide)
Packaging
10g
Price
$299
Updated
2024/03/01
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Scopolamine butylbromide Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Originator

Butylscopolamine,China Pharm

Uses

(?)-Scopolamine N-butyl bromide was used as standard in designing a procedure for quantification of compounds using CE-MS.8

Uses

Anticholinergic. Antispasmodic

Definition

ChEBI: Butylscopolamine bromide is an organic bromide salt of butylscopolamine. It is an antispasmodic drug which can relieve painful stomach cramps (including those linked with irritable bowel syndrome), bladder and menstrual cramps. It has a role as a muscarinic antagonist and an antispasmodic drug. It is an organic bromide salt and a quaternary ammonium salt. It contains a butylscopolamine.

Manufacturing Process

1300 g of scopolamine base and 350 g of n-butylbromide in 600 ml acetonitrile is heated at 65°C for 160 hours. The oil obtained is dissolved in methanol. The solution is cooled and crystalline scopolamine N-n-butylbromide is filtered. After recrystallization from methanol was obtained scopolamine N-n-butylbromide with melting point 142-144°C and [α]d 20 = -20.5° (3% solution in water); yield 65%.

Therapeutic Function

Anticholinergic, Spasmolytic, Antitussive

Biochem/physiol Actions

Competitive muscarinic acetylcholine receptor antagonist; antispasmodic.

Clinical Use

Symptomatic relief of gastrointestinal or genitourinary disorders due to smooth muscle spasm Bowel colic
Excessive respiratory secretions

target

AChR

Metabolism

The main metabolic pathway is the hydrolytic cleavage of the ester bond. Orally administered hyoscine butylbromide is excreted in the faeces and in the urine. Studies in man show that 2-5% of radioactive doses is eliminated renally after oral, and 0.7-1.6% after rectal administration. Approximately 90% of recovered radioactivity can be found in the faeces after oral administration. The urinary excretion of hyoscine butylbromide is less than 0.1% of the dose. The metabolites excreted via the renal route bind poorly to muscarinic receptors and are therefore not considered to contribute to the effect of the hyoscine butylbromide.

Scopolamine butylbromide Preparation Products And Raw materials

Raw materials

Preparation Products

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Scopolamine butylbromide Suppliers

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View Lastest Price from Scopolamine butylbromide manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Scopolamine butylbromide 149-64-4
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-21
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Scopolamine butylbromide; Flos?daturae extract 149-64-4
Price
US $0.00/G
Min. Order
1G
Purity
≥99% HPLC
Supply Ability
1000KG
Release date
2022-09-16
Wuhan Circle Star Chem-medical Technology Co.,Ltd
Product
Scopolamine butylbromide 149-64-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98
Supply Ability
1000
Release date
2025-01-10

149-64-4, Scopolamine butylbromideRelated Search:

Dimidium bromide Racanisodamine Allyl bromide Ethidium bromide Rocuronium bromide Cyhalofop-butyl L-Hyoscyamine Buprofezin 1-Bromobutane Vecuronium bromide Scopolamine hydrobromide Anisodamine Sodium bromate Scopolamine SCOPOLAMINE N-OXIDE HYDROBROMIDE Scopolamine Hydrobromide Trihydrate (-)-SCOPOLAMINE SCOPOLAMINE-D3 HYDROBROMIDE Hyoscine Butylbromide

  • BUTYLMIN
  • HYOSCINE BUTYLBROMIDE
  • HYOSCINE N-BUTYL BROMIDE
  • SCOPOLAMINI BUTYLBROMIDUM
  • (-)-SCOPOLAMINE N-BUTYL BROMIDE
  • SCOPOLAMINE N-BUTYL BROMIDE
  • (-)-N-BUTYLSCOPOLAMIDE BROMIDE
  • (-)-N-BUTYLSCOPOLAMINE BROMIDE
  • N-BUTYLSCOPOLAMMONIUM BROMIDE
  • 5-alpha-h-tropanium,8-butyl-6-beta,7-beta-epoxy-3-alpha-hydroxy-1-alpha-br
  • amisepan
  • buscapina
  • buscapine
  • buscol
  • buscolamin
  • buscolysin
  • buscolysine
  • buscopan
  • butylhyoscine
  • butylscopolaminebromide
  • butylscopolammoniumbromide
  • donopon
  • hyoscinebutobromide
  • hyoscin-n-butylbromid
  • hyoscin-n-butylbromide
  • joscine
  • monospan
  • n-butylhyoscinebromide
  • n-butylhyosciniumbromide
  • n-butylscopolaminiumbromide
  • omide,(-)-tropate
  • scobro
  • scobron
  • scobutil
  • scobutyl
  • scopolaminebromobutylate
  • scopolaminebutobromide
  • scopolaminebutylbromide
  • scopolan
  • sparicon
  • sporamin
  • stilbron
  • tirantil
  • hyoscine butylobromide
  • Hyoscine butyl bromide BP
  • HYOSCINE BUTYLBROMIDE STANDARD
  • ScopolaMine ButylborMide (Hyoscine ButylbroMide)
  • 3-Oxa-9-azoniatricyclo[3.3.1.02,4]nonane,9-butyl-7-[(2S)-3-hydroxy-1-oxo-2-phenylpropoxy]-9-Methyl-, broMide (1:1), (1a,2b,4b,5a,7b)-
  • Hyoscine butylbromide Impurity
  • Ding bromate scopolamine
  • Hyoscinen buty1bromide
  • Ding bromine scopolamine
  • ()-N-Butylscopolamine bromide ()-Scopolamine N-butyl bromide Hyoscine N-butyl bromide
  • (1S,2R,4S,5S)-9-butyl-7-[(3-hydroxy-2-phenylpropanoyl)oxy]-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide
  • (1S,2R,4S,5S)-9-butyl-7-{[(2S)-3-hydroxy-2-phenylpropanoyl]oxy}-9-methyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane bromide
  • (1S,2R,4S
  • (-)-SCOPOLAMINE N-BUTYL BROMIDE CHOLINERGIC ANTAGONIST
  • 3-Oxa-9-azoniatricyclo3.3.1.02,4nonane, 9-butyl-7-(2S)-3-hydroxy-1-oxo-2-phenylpropoxy-9-methyl-, bromide, (1.alpha.,2.beta.,4.beta.,5.alpha.,7.beta.)-