METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
- Product Name
- METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
- CAS No.
- 4093-28-1
- Chemical Name
- METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
- Synonyms
- ethyl p-acetaminosalicylate;Methyl 4-acetamidosalicylate;Methyl-4-(acetylamino)salicylat;Methyl 4-(Acetamido)-2-Methoxyb;methyl 4-(acetylamino)salicylate;Ethopabate USP Related Compound A;Methyl 4-(Acetylamino)-2-hydroxyben;METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE;Methyl-2-metroxy-4-acetylaminobenzoate;METHYL-2-METHOXY-4-ACETYLAMINOBENZOATE
- CBNumber
- CB9129788
- Molecular Formula
- C10H11NO4
- Formula Weight
- 209.2
- MOL File
- 4093-28-1.mol
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Property
- Melting point:
- 146-147°
- Boiling point:
- 405.1±35.0 °C(Predicted)
- Density
- 1.317±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.29±0.10(Predicted)
- color
- Light Orange to Light Brown
- InChI
- InChI=1S/C10H11NO4/c1-6(12)11-7-3-4-8(9(13)5-7)10(14)15-2/h3-5,13H,1-2H3,(H,11,12)
- InChIKey
- LCXHOHRQXZMSQN-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=C(NC(C)=O)C=C1O
- CAS DataBase Reference
- 4093-28-1(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M275280
- Product name
- Methyl4-Acetamido-2-hydroxybenzoate
- Packaging
- 10g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4758-1-41
- Product name
- Methyl 4-acetamido-2-hydroxybenzoate
- Packaging
- 100g
- Price
- $106
- Updated
- 2021/12/16
- Product number
- 2850AE
- Product name
- Methyl4-(acetylamino)-2-hydroxybenzenecarboxylate
- Packaging
- 100g
- Price
- $167
- Updated
- 2021/12/16
- Product number
- AMTGC069
- Product name
- Methyl4-acetamido-2-hydroxybenzoate
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- 043905
- Product name
- Methyl 4-(acetylamino)-2-hydroxybenzenecarboxylate
- Purity
- >95%
- Packaging
- 25g
- Price
- $29
- Updated
- 2021/12/16
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Chemical Properties,Usage,Production
Chemical Properties
Light Brown Solid
Uses
Methyl 4-Acetamido-2-hydroxybenzoate is a reagent used in the synthesis of Mosapride.
Synthesis
75-36-5
4136-97-4
4093-28-1
Methyl 4-amino-2-hydroxybenzoate (50.7 g, 303.6 mmol) was dissolved in ethyl acetate (750 mL) with stirred water (250 mL) and sodium bicarbonate solution (34.9 g). The mixture was cooled to 0°C over 15 minutes, followed by slow dropwise addition of acetyl chloride (29.7 mL, 415.5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the organic and aqueous layers were separated, the organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the white solid product methyl 4-acetamido-2-hydroxybenzoate (63.5 g, 99% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ10.86 (broad single peak, 1H), 7.78 (double peak, J=8.6Hz, 1H), 7.23 (single peak, 1H), 7.16 (broad single peak, 1H), 7.10 (double peak, J=8.6Hz, 1H), 6.13 (broad single peak, 1H), 3.92 (single peak, 3H), 2.19 ( single peak, 3H); mass spectrum (m/z): 208 (MH)+.
References
[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0095-0097
[3] Organic Process Research and Development, 2010, vol. 14, # 1, p. 92 - 98
[4] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0955; 0956; 0957
[5] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Suppliers
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View Lastest Price from METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE manufacturers
- Product
- METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE 4093-28-1
- Price
- US $30.00-20.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200000KG
- Release date
- 2024-08-01
- Product
- Methyl 4-acetamido-2-hydroxybenzoate 4093-28-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25