ChemicalBook > CAS DataBase List > METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE

METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE

Product Name
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
CAS No.
4093-28-1
Chemical Name
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
Synonyms
ethyl p-acetaminosalicylate;Methyl 4-acetamidosalicylate;Methyl-4-(acetylamino)salicylat;Methyl 4-(Acetamido)-2-Methoxyb;methyl 4-(acetylamino)salicylate;Ethopabate USP Related Compound A;Methyl 4-(Acetylamino)-2-hydroxyben;METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE;Methyl-2-metroxy-4-acetylaminobenzoate;METHYL-2-METHOXY-4-ACETYLAMINOBENZOATE
CBNumber
CB9129788
Molecular Formula
C10H11NO4
Formula Weight
209.2
MOL File
4093-28-1.mol
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METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Property

Melting point:
146-147°
Boiling point:
405.1±35.0 °C(Predicted)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.29±0.10(Predicted)
color 
Light Orange to Light Brown
InChI
InChI=1S/C10H11NO4/c1-6(12)11-7-3-4-8(9(13)5-7)10(14)15-2/h3-5,13H,1-2H3,(H,11,12)
InChIKey
LCXHOHRQXZMSQN-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=C(NC(C)=O)C=C1O
CAS DataBase Reference
4093-28-1(CAS DataBase Reference)
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Safety

HazardClass 
IRRITANT
HS Code 
2916399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
M275280
Product name
Methyl4-Acetamido-2-hydroxybenzoate
Packaging
10g
Price
$95
Updated
2021/12/16
SynQuest Laboratories
Product number
4758-1-41
Product name
Methyl 4-acetamido-2-hydroxybenzoate
Packaging
100g
Price
$106
Updated
2021/12/16
AK Scientific
Product number
2850AE
Product name
Methyl4-(acetylamino)-2-hydroxybenzenecarboxylate
Packaging
100g
Price
$167
Updated
2021/12/16
AK Scientific
Product number
AMTGC069
Product name
Methyl4-acetamido-2-hydroxybenzoate
Packaging
1g
Price
$10
Updated
2021/12/16
Matrix Scientific
Product number
043905
Product name
Methyl 4-(acetylamino)-2-hydroxybenzenecarboxylate
Purity
>95%
Packaging
25g
Price
$29
Updated
2021/12/16
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METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Chemical Properties,Usage,Production

Chemical Properties

Light Brown Solid

Uses

Methyl 4-Acetamido-2-hydroxybenzoate is a reagent used in the synthesis of Mosapride.

Synthesis

75-36-5

4136-97-4

4093-28-1

Methyl 4-amino-2-hydroxybenzoate (50.7 g, 303.6 mmol) was dissolved in ethyl acetate (750 mL) with stirred water (250 mL) and sodium bicarbonate solution (34.9 g). The mixture was cooled to 0°C over 15 minutes, followed by slow dropwise addition of acetyl chloride (29.7 mL, 415.5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. After completion of the reaction, the organic and aqueous layers were separated, the organic layer was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the white solid product methyl 4-acetamido-2-hydroxybenzoate (63.5 g, 99% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ10.86 (broad single peak, 1H), 7.78 (double peak, J=8.6Hz, 1H), 7.23 (single peak, 1H), 7.16 (broad single peak, 1H), 7.10 (double peak, J=8.6Hz, 1H), 6.13 (broad single peak, 1H), 3.92 (single peak, 3H), 2.19 ( single peak, 3H); mass spectrum (m/z): 208 (MH)+.

References

[1] Patent: WO2013/42135, 2013, A1. Location in patent: Page/Page column 11
[2] Patent: US2014/187581, 2014, A1. Location in patent: Paragraph 0095-0097
[3] Organic Process Research and Development, 2010, vol. 14, # 1, p. 92 - 98
[4] Patent: US2016/251376, 2016, A1. Location in patent: Paragraph 0955; 0956; 0957
[5] Bioorganic and Medicinal Chemistry Letters, 1996, vol. 6, # 22, p. 2657 - 2662

METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Preparation Products And Raw materials

Raw materials

METHYL 4-AMINOSALICYLATE 4-Aminosalicylic acid

Preparation Products

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METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE Suppliers

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View Lastest Price from METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE 4093-28-1
Price
US $30.00-20.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2024-08-01
Career Henan Chemical Co
Product
Methyl 4-acetamido-2-hydroxybenzoate 4093-28-1
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200kg
Release date
2018-12-25

4093-28-1, METHYL 4-ACETAMIDO-2-HYDROXYBENZOATERelated Search:

Methyl 4-acetamido-5-bromo-2-methoxybenzoate Methyl 4-acetamido-5-chloro-2-methoxybenzoate Ethopabate Methyl 4-acetamido-2-methoxybenzoate METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE 4-Acetamidosalicylic acid o-Anisic acid Methyl salicylate METHYL 5-(ACETYLAMINO)-2-HYDROXYBENZOATE AURORA 1347 AURORA 4653 AURORA 841 AURORA 5411 AURORA 4182 AURORA 2558 AURORA 4468 AURORA 1780 AURORA 1193

  • Methyl 4-acetamido-2-hydroxybenzoate 95+%
  • Methyl-4-(acetylamino)salicylat
  • methyl 4-(acetylamino)salicylate
  • METHYL 4-(ACETYLAMINO)-2-HYDROXYBENZENECARBOXYLATE
  • METHYL 4-(ACETYLAMINO)-2-HYDROXYBENZOATE
  • METHYL 4-ACETAMIDO-2-HYDROXYBENZOATE
  • Methyl-2-metroxy-4-acetylaminobenzoate
  • 2-Methoxy-4-acetylaminobenzoicacidmethylester
  • 4-Acetamidosalicylic acid methyl ester
  • METHYL-2-METHOXY-4-ACETYLAMINOBENZOATE
  • 4-ACETAMIDO-2-HYDROXY-BENZOIC ACID METHYL ESTER
  • Methyl 4-(acetylamino)-2-hydroxybenzoate, Methyl 4-acetamidosalicylate
  • Methyl 4-(acetylamino)-2-hydroxybenzoate, Methyl 4-acetamidosalicylate, 3-Hydroxy-4-(methoxycarbonyl)acetanilide
  • Methyl 2-Hydroxy-4-(acetylaMino)benzoate
  • Methyl 4-acetamidosalicylate
  • Methyl 4-(Acetamido)-2-Methoxyb
  • 4-ACETYLAMINO-2-HYDROXY-BENZOIC ACID METHYL ESTER
  • 4-ACETYLAMINO-2-METHOXY-BENZOIC ACID METHYL ESTER
  • Methyl 4-(Acetylamino)-2-hydroxyben
  • Benzoic acid, 4-(acetylamino)-2-hydroxy-, methyl ester
  • Methyl 4-acetamido-2-hydroxybenzoate Manufacturer
  • ethyl p-acetaminosalicylate
  • Ethopabate USP Related Compound A
  • Benzoic acid, 4-(acetylamino)-2-hydroxy-, methyl ester (9CI, ACI)
  • 4-(acetylamino)-2-hydroxy-Benzoic acid methyl ester (9CI ACI)
  • Acetylaminosalicylic acid methyl ester
  • 4093-28-1
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Organic acids
  • Aromatic Esters