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Isoliquiritigenin

Product Name
Isoliquiritigenin
CAS No.
961-29-5
Chemical Name
Isoliquiritigenin
Synonyms
ISL;ISOLIQUIRTIGENIN;(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;gu17;Isoliquiritigen;Isqliquiritigenin;ISOLIQUIRITIGENIN;ISOLIQUIRITIGENIN(P);Isoliquiritigenin>ISOLIQUIRITIGENIN(RG)
CBNumber
CB9131280
Molecular Formula
C15H12O4
Formula Weight
256.25
MOL File
961-29-5.mol
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Isoliquiritigenin Property

Melting point:
206-210°C
Boiling point:
504.0±42.0 °C(Predicted)
Density 
1.384±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: <0.1 mg/mL
form 
powder
pka
7.50±0.35(Predicted)
color 
yellow to orange
Sensitive 
Light Sensitive & Hygroscopic
BRN 
1914296
InChIKey
DXDRHHKMWQZJHT-FPYGCLRLSA-N
LogP
3.110 (est)
CAS DataBase Reference
961-29-5(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-37
WGK Germany 
3
RTECS 
FL7080000
HS Code 
29145090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I3766
Product name
Isoliquiritigenin
Purity
powder
Packaging
10mg
Price
$461
Updated
2024/03/01
Sigma-Aldrich
Product number
38986
Product name
Isoliquiritigenin
Purity
analytical standard
Packaging
50mg
Price
$195
Updated
2024/03/01
TCI Chemical
Product number
I0822
Product name
Isoliquiritigenin
Purity
>97.0%(HPLC)(T)
Packaging
100mg
Price
$23
Updated
2024/03/01
TCI Chemical
Product number
I0822
Product name
Isoliquiritigenin
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$170
Updated
2024/03/01
Alfa Aesar
Product number
H26920
Product name
2',4,4'-Trihydroxychalcone, 97%
Packaging
1g
Price
$88.6
Updated
2021/12/16
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Isoliquiritigenin Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

aldose reductase inhibitor, antineoplastic, antiinflammatory

Uses

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants that displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. ISL induces quinone reductase-1, a phase II enzyme that deactivates radicals and electrophiles, with a concentration required to double activity (CD) value of 1.8 μM in murine hepatoma cells.

Definition

ChEBI: Isoliquiritigenin is a member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, a biological pigment, a NMDA receptor antagonist, a GABA modulator, a metabolite, an antineoplastic agent and a geroprotector. It is functionally related to a trans-chalcone. It is a conjugate acid of an isoliquiritigenin(1-).

General Description

Isoliquiritigenin is an aromatic ketone and belongs to the chalcone group of compound. It is derived from licorice and is a component in medicine and food.

Biochem/physiol Actions

Isoliquiritigenin is a soluble guanylyl cyclase activator and possesses antitumor activity. It also possesses antioxidant, antiplatelet and estrogenic properties.

Anticancer Research

It is extracted from Dipteryx odorata seeds, found to be active in induction of quininereductase, and thus prevents chemical carcinogenesis. In a dose- and time-dependentmanner, it significantly inhibits the proliferation of prostate cancer cells,and this isoliquiritigenin-induced cell cycle arrest and antiproliferative effects maybe manifested by growth arrest- and DNA damage-inducible gene 153 (GADD153).It induces apoptosis in prostate cancer cells through mitochondrial apoptosispathway in which mitochondrial membrane potential is disrupted, cytochrome-cand Smac/Diablo are released, and caspase-9 is activated. It is reported to enhancethe expression of universal inhibitor of cyclin-dependent kinases, p21CIP1/WAF1, in adose- and time-dependent manner in A549 human lung cancer cells (Kanazawaet al. 2003; Ii et al. 2004; Balunas and Kinghorn 2005; Jung et al. 2006).

storage

+4°C

Isoliquiritigenin Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoliquiritigenin Suppliers

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View Lastest Price from Isoliquiritigenin manufacturers

Hebei Kingfiner Technology Development Co.Ltd
Product
Isoliquiritigenin 961-29-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
500000kg
Release date
2024-05-07
Hebei Duling International Trade Co. LTD
Product
Isoliquiritigenin 961-29-5
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000 Ton
Release date
2023-02-17
Hebei Mojin Biotechnology Co., Ltd
Product
Isoliquiritigenin 961-29-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-08-28

961-29-5, IsoliquiritigeninRelated Search:

Isoliquiritigenin Glycyrrhizine(R19,R21) 10-20%,13-20% HPLC Tetraphenylcyclopentadienone LIQUIRITIGENIN Glycyrrhizic acid 2,2',4,4'-Tetrahydroxybenzophenone 1-Phenyl-2-nitropropene DGL Benzil 3,4-Dihydroxyacetophenone 4'-Hydroxyacetophenone Isocyclosporin A Potassium Phosphate Monobasic isoliquiritin apioside ISOLIQUIRITIN LIQUIRITIN(SH) LICOCHALCONE-A Liguiritigenin-7-O-D-apiosyl-4’-O-D-glucoside

  • gu17
  • Isqliquiritigenin
  • ISOLIQUIRTEGENIN (2',4,4'-TRIHYDROXYCHAL
  • ISOLIQUIRITIGENIN(P)
  • ISOLIQUIRITIGENIN(RG)
  • (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2μ,4μ-Trihydroxychalcone
  • Isoliquiritigenin，4,2',4'-Trihydroxychalcone
  • (E)-2',4,4'-Trihydroxychalcone
  • 2',4,4'-Trihydroxy-trans-chalcone
  • 2’,4,4’-trihydroxy-chalcon
  • 4,4’-trihydroxychalcone(e)-2
  • 4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-((e)-2-propen-1-on
  • Isoliquiritigenin 961-29-5
  • (2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
  • ISL
  • (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one 2',4,4'-Trihydroxychalcone
  • Isoliquiritigenin, >=98%
  • (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
  • Isoliquiritigenin (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
  • 2',4',4-TRIHYDROXYCHALCONE
  • ISOLIQUIRTIGENIN
  • ISOLIQUIRITIGENIN
  • (e)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
  • 4,2',4'-TRIHYDROXYCHALCONE
  • Isoliquiritigen
  • Isoliquiritigenin&gt
  • Isoliquiritigenin Standard
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-
  • Isoliquiritigenin USP/EP/BP
  • Isoliquiritigenin (GU17)
  • TIANFUCHEM--961-29-5--Isoliquiritigenin
  • Isoliquiritigenin Glycyrrhiza extract
  • Isoliquiritigenin CAS
  • 961-29-5
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Guanylyl Cyclase Activators
  • The group of Liquorice
  • sy
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chalcones
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors