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HEMATOPORPHYRIN

Product Name
HEMATOPORPHYRIN
CAS No.
14459-29-1
Chemical Name
HEMATOPORPHYRIN
Synonyms
hp;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase;Hematoporphyrin Base
CBNumber
CB9134564
Molecular Formula
C34H38N4O6
Formula Weight
598.69
MOL File
14459-29-1.mol
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HEMATOPORPHYRIN Property

Melting point:
172.5°C
Boiling point:
649.58°C (rough estimate)
Density 
1.328
refractive index 
1.6000 (estimate)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Sparingly), Methanol (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
Purple to Black
Merck 
13,4653
Stability:
Light Sensitive
EPA Substance Registry System
21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TS5500000
8-10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
H245678
Product name
Hematoporphyrin(TechnicalGrade,~30%)
Packaging
500mg
Price
$175
Updated
2021/12/16
Usbiological
Product number
356334
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
356327
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
356330
Product name
HP
Packaging
48Tests
Price
$588
Updated
2021/12/16
Usbiological
Product number
383280
Product name
HP
Packaging
96Tests
Price
$599
Updated
2021/12/16
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HEMATOPORPHYRIN Chemical Properties,Usage,Production

Uses

antidepressant, antineoplastic

Uses

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

Definition

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

Hazard

Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.

Purification Methods

Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]

HEMATOPORPHYRIN Preparation Products And Raw materials

Raw materials

Preparation Products

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HEMATOPORPHYRIN Suppliers

Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Shanghai Xianhui Pharmaceutical Co., Ltd.
Tel
021-67792654 13564796979
Fax
86 21 67792654
Email
shxh2006@outlook.com
Country
China
ProdList
32
Advantage
62
Shanghai XueEr Pharmaceutical Technology Co., Ltd
Tel
021-34622192 13917187091
Fax
86-21-34622765
Email
1021708276@qq.com
Country
China
ProdList
79
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
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View Lastest Price from HEMATOPORPHYRIN manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Hematoporphyrin 14459-29-1
Price
US $60.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-06-04
airuikechemical co., ltd.
Product
Hematoporphyrin 14459-29-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
20 tons
Release date
2024-03-29
Dideu Industries Group Limited
Product
Hematoprophyrin
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26

14459-29-1, HEMATOPORPHYRINRelated Search:


  • 1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionicacid
  • 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-te
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-18-porphinedipropionicacid
  • hematoporphyrinix
  • ANTI-HPR antibody produced in mouse
  • 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-Porphine-2,18-dipropanoic acid
  • 7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionic acid
  • NSC-59265
  • Photodyn
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphin-2-yl]propionic acid
  • 3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid
  • 1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid
  • HeMatoporphyrin >=45%
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  • 8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID
  • HAEMATOPORPHYRIN
  • HEMATOPORPHYRIN
  • HEMATOPORPHYRINE
  • HEMATOPORPHYRIN IX BASE
  • hematoporphyrin free base
  • HematoporphyrineBase
  • 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-
  • A-259H10.2
  • Hematoporphyrin (Technical Grade, ~30%)
  • Recombinant Human Haptoglobin/HP Protein, His Tag
  • Recombinant Human Haptoglobin/HP/HP Protein, His Tag
  • HEMATOPORPHYRIN USP/EP/BP
  • Hematoprophyrin USP/EP/BP
  • Hematoporphyrin Base
  • 14459-29-1
  • 14459-21-1
  • C34H38N4O6
  • BioChemical
  • Biochemicals and Reagents
  • Natural Dyes
  • Proteins and Derivatives
  • Plasma, Blood, and Related Proteins and Reagents
  • Plasma & Blood Proteins