ChemicalBook > CAS DataBase List > HEMATOPORPHYRIN

HEMATOPORPHYRIN

Product Name: HEMATOPORPHYRIN
CAS No.: 14459-29-1
Chemical Name: HEMATOPORPHYRIN
Synonyms: hp;Ba1-647;Photodyn;NSC-59265;A-259H10.2;HEMATOPORPHYRIN;HAEMATOPORPHYRIN;HEMATOPORPHYRINE;hematoporphyrinix;HematoporphyrineBase
CBNumber: CB9134564
Molecular Formula: C34H38N4O6
Formula Weight: 598.69
MOL File: 14459-29-1.mol

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HEMATOPORPHYRIN Property

Melting point:: 172.5°C
Boiling point:: 649.58°C (rough estimate)
Density: 1.328
refractive index: 1.6000 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Sparingly), Methanol (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Purple to Black
biological source: mouse
Merck: 13,4653
Stability:: Light Sensitive
EPA Substance Registry System: 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl- (14459-29-1)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: TS5500000
F: 8-10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1411905
Product name: ANTI-HPR antibody produced in mouse
Purity: purified immunoglobulin, buffered aqueous solution
Packaging: 50 μg
Price: $541
Updated: 2025/07/31

TRC

Product number: H245678
Product name: Hematoporphyrin(TechnicalGrade,~30%)
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Usbiological

Product number: 356334
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 356327
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 356330
Product name: HP
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

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HEMATOPORPHYRIN Chemical Properties,Usage,Production

Chemical Properties

Red-purple crystals, soluble in ethanol, slightly soluble in ether and chloroform, insoluble in water.

Uses

antidepressant, antineoplastic

Uses

Hematoporphyrin (Photodyn, Sensibion) is a porphyrin prepared from hemin. It is a derivative of protoporphyrin IX, where the two vinyl groups have been hydrated (coverted to alcohols). It is used as a photosensitizer in photodynamic therapy. Acetylation of hematoporphyrin followed by hydrolysis of the product of that reaction affords a mixture called hematoporphyrin derivative (HPD), which is also used in photodynamic therapy. Hematoporphyrin has also been used as an antidepressant and antipsychotic since the 1920s.

Definition

ChEBI: A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.

Hazard

Toxic. Reported to be preferentially absorbed by cancerous tissues, making them fluoresce under UV light.

in vivo

Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels^[3].

Animal Model:	Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130^[3]
Dosage:	5, 10 mg/kg
Administration:	I.p. daily during the initial 10 days and biweekly for the next 2 months
Result:	No tumor could be palpated a few days after exposure of the rats to light. The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40).

IC 50

Human Endogenous Metabolite

Purification Methods

Purify it by dissolving it in EtOH Hematoporphyrin and adding H2O or Et2O to give deep red crystals. It has also been recrystallised from MeOH. UV has max at 615.5, 565, 534.4 and 499.5nm in 0.1N NaOH, and 597, 619, 634, 653, 683 and 701nm in 2N HCl [Falk Porphyrins and Metalloporphyrins Elsevier, NY, p 175 1964, LCCCNo 63-19821.] It is used in the affinity chromatographic purification of Heme proteins [Olsen Methods Enzymol 123 324 1986]. The O-methyl-dimethyl ester has m 203-206o (from CHCl3/MeOH), and the O,O'-dimethyl-dimethyl ester has m 145o (from CHCl3/MeOH). [Paul Acta Chem Scand 5 389 1951, Beilstein 26 III/IV 3157, and 3158 for the HCl.]

HEMATOPORPHYRIN Preparation Products And Raw materials

Raw materials

Hemin

Preparation Products

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View Lastest Price from HEMATOPORPHYRIN manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Hematoporphyrin 14459-29-1
Price: US $18.00-48.00/KG
Min. Order: 0.01KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-19

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hematoporphyrin 14459-29-1
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg/week
Release date: 2024-06-04

airuikechemical co., ltd.

Product: Hematoporphyrin 14459-29-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 20 tons
Release date: 2024-03-29

14459-29-1, HEMATOPORPHYRINRelated Search:

HEMATOPORPHYRIN DIHYDROCHLORIDE,HEMATOPORPHYRIN IX DIHYDROCHLORIDE (Z)-Hex-4-en-1-ol 3-PENTEN-2-OL HEMATOPORPHYRIN 3-BUTEN-2-OL Allylacetic acid 3-Methyl-2-buten-1-ol 4-Penten-1-ol (E)-4-Hexen-1-ol 4-HEXENOIC ACID 3-METHYLPYRROLE PORPHINE HEMATOPORPHYRIN IX DIMETHYL ESTER 4-METHYL-3-PENTEN-2-OL 3,4-DIMETHYLPYRROLE 3-METHYL-3-BUTEN-2-OL 5-METHYL-4-HEXENOIC ACID 3-ETHYL-1H-PYRROLE

1,3,5,8-tetramethyl-2,4-bis(alpha-hydroxyethyl)prophine-6,7-dipropionicacid

21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-te

7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-18-porphinedipropionicacid

hematoporphyrinix

ANTI-HPR antibody produced in mouse

7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-Porphine-2,18-dipropanoic acid

7,12-Bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-21H,23H-porphyrin-2,18-dipropionic acid

NSC-59265

Photodyn

3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphin-2-yl]propionic acid

3-[18-(2-carboxyethyl)-7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid

1,3,5,8-Tetramethyl-2,4-bis(α-hydroxyethyl)porphine-6,7-dipropionic acid

HeMatoporphyrin >=45%

8,13-BIS(1-HYDROXYETHYL)-3,7,12,17-TETRAMETHYL-21H,23H-PORPHINE-2,18-DIPROPIONIC ACID

HAEMATOPORPHYRIN

HEMATOPORPHYRIN

HEMATOPORPHYRINE

HEMATOPORPHYRIN IX BASE

hematoporphyrin free base

HematoporphyrineBase

21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-

A-259H10.2

Hematoporphyrin (Technical Grade, ~30%)

Recombinant Human Haptoglobin/HP Protein, His Tag

Recombinant Human Haptoglobin/HP/HP Protein, His Tag

HEMATOPORPHYRIN USP/EP/BP

Hematoprophyrin USP/EP/BP

Hematoporphyrin Base

Ba1-647

14459-29-1

14459-21-1

C34H38N4O6

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