indicine-N-oxide

Product Name: indicine-N-oxide
CAS No.: 41708-76-3
Chemical Name: indicine-N-oxide
Synonyms: NSC132319;Indicin-N-oxid;indicine-N-oxide;Indicine N-oxide-RM;(+)-Indicine N-oxide;DNAWGBOKUFFVMB-PZIGJSDBSA-N;(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate;Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aS)-2,3,5,7a-tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl ester, (2R,3S)-
CBNumber: CB91364920
Molecular Formula: C15H25NO6
Formula Weight: 315.36
MOL File: 41708-76-3.mol

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indicine-N-oxide Property

Melting point:: 130.5°C (rough estimate)
Boiling point:: 454.91°C (rough estimate)
Density: 1.1359 (rough estimate)
refractive index: 1.5000 (estimate)
pka: 12.54±0.29(Predicted)

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Safety

RIDADR: 1544
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83235
Product name: Indicine N-oxide
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $916
Updated: 2024/03/01

TRC

Product number: I521105
Product name: IndicineN-Oxide
Packaging: 5mg
Price: $1260
Updated: 2021/12/16

TRC

Product number: I521105
Product name: IndicineN-Oxide
Packaging: 0.5mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 452316
Product name: Indicine N-Oxide
Packaging: 500ug
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0011660
Product name: INDICINE-N-OXIDE
Purity: 95.00%
Packaging: 5MG
Price: $501.73
Updated: 2021/12/16

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indicine-N-oxide Chemical Properties,Usage,Production

Description

Heliotropiurn indicurn also contains this base which has the structure given above based upon comparison with the preceding alkaloid. The base has proved to be highly active against transplanted neoplasts, Walker-256 carcinosarcoma, melanoma B-16, leukaemia L-12l 0, leukaemia P-388 and leukaemia P-1534 in mice and rats, giving up to 91 per cent inhibition of transplanted growth at a daily dosage of 200 mgm. per kilo.

Uses

Indicine N-oxide is a pyrrolizidine alkaloid that is isolated from Heliotropium indicum, one of the most widely used herbs in India. Indicine N-oxide exhibits antitumour and antimitotic activity in humans, and has subsequently undergone Phase I & II trials in adults and children with leukemia and solid tumours.

References

Rao, McBride., U.S. Patent, 3,717,710 February 20,1973

indicine-N-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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indicine-N-oxide Suppliers

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41708-76-3, indicine-N-oxideRelated Search:

TRIETHYLAMINE N-OXIDE retronecine Trimethylamine N-oxide dihydrate DL-Norephedrine hydrochloride 2-(S)-Hydroxy-3-methylbutyric acid methyl ester ALLYL 2-ETHYLBUTYRATE Trimethylamine N-oxide (S)-ALLYL LACTATE 2,3,5,7A-TETRAHYDRO-1H-PYRROLIZINE indicine-N-oxide

indicine-N-oxide

Indicin-N-oxid

DNAWGBOKUFFVMB-PZIGJSDBSA-N

Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aS)-2,3,5,7a-tetrahydro-1-hydroxy-4-oxido-1H-pyrrolizin-7-yl]methyl ester, (2R,3S)-

(7R,8R)-7-hydroxy-4-oxido-5,6,7,8-tetrahydro-3H-pyrrolizin-4-ium-1-yl]methyl (2R)-2-hydroxy-2-[(1S)-1-hydroxyethyl]-3-methylbutanoate

(+)-Indicine N-oxide

NSC132319

Indicine N-oxide-RM

41708-76-3