cycloastragenol

ChemicalBook > CAS DataBase List > cycloastragenol

Description Biological Activity Laboratory Procedures

Product Name: cycloastragenol
CAS No.: 84605-18-5
Chemical Name: cycloastragenol
Synonyms: Cyclogalegigenin;Cycloastrageno;(3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol;Cyclogalegenin;Cyclogalagenin;cas 84605-18-5;cas 78574-94-4;Cyclogalgeginin;Cycloastragenol, >98%;cas 84605-18-5 78574-94-4
CBNumber: CB91378734
Molecular Formula: C30H50O5
Formula Weight: 490.71
MOL File: 84605-18-5.mol

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cycloastragenol Property

Melting point:: >220°C (dec.)
Boiling point:: 617.2±55.0 °C(Predicted)
Density: 1.20
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly)
form: Solid
pka: 14.57±0.29(Predicted)
color: White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11722
Product name: Cycloastragenol
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 11722
Product name: Cycloastragenol
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 11722
Product name: Cycloastragenol
Purity: ≥98%
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 11722
Product name: Cycloastragenol
Purity: ≥98%
Packaging: 25mg
Price: $381
Updated: 2024/03/01

TRC

Product number: C987810
Product name: Cycloastragenol
Packaging: 1g
Price: $210
Updated: 2021/12/16

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cycloastragenol Chemical Properties,Usage,Production

Description

Cycloastragenol (TA-65), a small-triterpenoid purified from the root of an Asian medicinal herb, has currently received particular attention for its potential to regulate transcription of telomerase. TA-65 is capable to increase average telomere length and to decrease the percentage of critically short telomeres and DNA damage in MEFs that harbor critically short telomeres. The effects on telomerase appear to be in common with other triterpenoid saponins (ie, ginsenosides RG1 and Rg3). These compounds at concentrations from 1 to 20 μM were reported to protect against IL-1β-, H2O2-, and tert-butylhydroperoxide-induced senescence in human chondrocytes, endothelial progenitor cells and fibroblasts, respectively.

Biological Activity

Cycloastragenol, the aglycone derivative of astragaloside A, can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.

Laboratory Procedures

Cycloastragenol is supplied as a crystalline solid. A stock solution may be made by dissolving the cycloastragenol in the solvent of choice. Cycloastragenol is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of cycloastragenol in these solvents is approximately 10, 3, and 25 mg/ml, respectively.
Cycloastragenol is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, cycloastragenol should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

Uses

Cycloastragenol is an aglycone derivative of astragaloside IV found in the root of Korean Astragalus membranaceus.

Definition

ChEBI: A sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus.

cycloastragenol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from cycloastragenol manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Cycloastragenol,98% 84605-18-5
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 3.5%-98%
Supply Ability: 20tons
Release date: 2024-01-03

Hebei Duling International Trade Co. LTD

Product: cycloastragenol 84605-18-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 tons
Release date: 2022-10-17

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Cycloastragenol 84605-18-5
Price: US $120.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-05-22

84605-18-5, cycloastragenolRelated Search:

β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-3-[(3,4-di-O-acetyl-β-D-xylopyranosyl)oxy]-20, 24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl Isoastragaloside I Cycloastragenol Methylnissolin Astraganoside Barbury Wolfberry fruit P.E. Genipin CALYCOSIN 7-O-GLUCOSIDE ASTRAGALUS ROOT RGBRM Galangin Astragaloside IV ASTRAGALOSIDE 2-(CHLOROMETHYL)-4-(4-NITROPHENYL)-1,3-THIAZOLE Total Flavonoids from Astragali Radix Astragaloside A 5,7-Dihydrox -4'-methoxyisoflavone ASTRAGALOSIDE I Triptolide

(3b,5ξ,6a,9ξ,10ξ,16b,17ξ,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

(3beta,6alpha,16beta,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

(3b,6a,16b,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

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Cyclogalegenin

Cyclogalegigenin

Cyclogalgeginin

CYCLOGALAGENIN; CYCLOGALEGENIN; CYCLOGALEGIGENIN

84605-18-5 Cycloastragenol Plant Extract Powder

98% Cycloastragenol Powder from Astragulus Extract

Cycloastrageno

Cycloastragenol, >98%

Cycloastragenol (Cyclogalagenin

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,24R)-

Astragalus Extract HPLC Test 98% Cycloastragenol Powder?84605-18-5

5-Amino-o-cresol 2835-95-2

cas 84605-18-5 78574-94-4

cas 84605-18-5

Cycloastragenol 98% cas 78574-94-4

cas 78574-94-4

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,24R)-

84605-18-5

48574-94-4

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

palnt extract

84605-18-5