5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID

Product Name: 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
CAS No.: 27069-16-5
Chemical Name: 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID
Synonyms: CHEMBRDG-BB 7270767;3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBO&;5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID;5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid ,97%;5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE);5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ISO 9001：2015 REACH
CBNumber: CB9139817
Molecular Formula: C11H10N2O3
Formula Weight: 218.21
MOL File: 27069-16-5.mol

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5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Property

Melting point:: 221-225 °C(lit.)
Boiling point:: 516.9±45.0 °C(Predicted)
Density: 1.340±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 3.93±0.10(Predicted)
form: solid
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29331990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CBR01174
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $73.1
Updated: 2025/07/31

TRC

Product number: M329598
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 138565
Product name: 5-(4-Methoxy-phenyl)-2H-pyrazole-3-carboxylic acid
Purity: 95%+
Packaging: 1g
Price: $101
Updated: 2021/12/16

AK Scientific

Product number: W5020
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Packaging: 250mg
Price: $163
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK217638
Product name: 5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $191
Updated: 2021/12/16

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5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

55558-77-5

27069-16-5

4.1.1.1 Synthesis of 5-(4-methylphenyl)-1H-pyrazole-3-carboxylic acid (1): 0.4 g of 4-(4-methylphenyl)-2,4-dioxobutanoic acid was dissolved in 20 mL of glacial acetic acid in a 50 mL round bottom flask. Under stirring conditions, 280 μL (3 equivalents) of hydrazine monohydrate (N2H4-H2O) was added slowly and dropwise to the solution. Immediately after the dropwise addition of hydrazine, the solution changed to a light yellow color. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was poured into 50 mL of water and stirred overnight. The white precipitate was collected by filtration, dried in air and recrystallized from a solvent mixture of hexane/ethanol (about 9:1) to give 0.34 g of product in 87% yield. 4.1.2.22 Synthesis of 5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (22): 0.50 g of 4-(4-methoxyphenyl)-2,4-dioxobutanoic acid was used as a starting material, and 0.45 g of the product was obtained in 92% yield by following the same procedure as above. The product is a white solid with a melting point of 226-228 °C (decomposition, hexane/ethyl acetate). The molecular formula was C11H10N2O3 and the molecular weight was 218.21. ESI-MS: [M+H]+ calculated value was 219.07642, measured value was 219.07540. IR (ν, cm-1): 3309, 3249 (N-H stretching vibration), 1679 (C=O stretching vibration), 1456, 1206. 1H NMR ( 200MHz, DMSO-d6) δ (ppm): 3.77 (s, 3H, OCH3), 6.99 (d, J=8.99Hz, 2H, Ar-H), 7.09 (s, 1H, pyrazole-H), 7.76 (d, J=8.42Hz, 2H, Ar-H), 13.21 (br, COOH).13C NMR ( 50MHz, DMSO-d6) δ (ppm): 55.45 (OCH3), 104.75, 114.60, 123.70, 127.00, 140.62, 147.45, 159.57, 162.43.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4649 - 4659

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

4'-Methoxyacetophenone Ethanol Hydrazine sulfate Potassium hydroxide Diethyl oxalate Sodium

Preparation Products

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5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID Suppliers

China 52 Germany 1 Hungary 1 India 2 Russia 2 Switzerland 1 Ukraine 1 United Kingdom 2 United States 16 Global 78

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27069-16-5, 5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACIDRelated Search:

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID 2-BENZO[1,3]DIOXOL-5-YL-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-(4-ETHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 2-(4-METHOXYPHENYL)-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID 5-(2,3-DIHYDRO-BENZO[1,4]DIOXIN-6-YL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER 2-(4-METHOXYPHENYL)-5-METHYL-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-METHYL-2-(4-TRIFLUOROMETHOXYPHENYL)-3H-IMIDAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 5-(4-METHOXYPHENYL)-1-PHENYL-1H-PYRAZOLE-3-CARBOXYLIC ACID 5-BENZO[1,3]DIOXOL-5-YL-2H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL 3-(4-METHOXYPHENYL)-1-METHYL-1H-PYRAZOLE-5-CARBOXYLATE 5-(3,4-DIMETHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 5-(2,4-DIMETHOXY-PHENYL)-2H-PYRAZOLE-3-CARBOXYLIC ACID 3-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)-1-(2-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-(2,3-DIHYDROBENZO[B][1,4]DIOXIN-7-YL)-1-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBOXYLIC ACID 3-(2-METHOXYPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-(4-METHOXYPHENYL)-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

CHEMBRDG-BB 7270767

3-(4-METHOXYPHENYL)-1H-PYRAZOLE-5-CARBO&

5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE)

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID

5-(4-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid ,97%

5-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ISO 9001：2015 REACH

27069-16-5

Pyrazoles

Heterocyclic Compounds

Building Blocks

Heterocyclic Building Blocks

Pyrazoles