Chlorphenamine maleate

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Chlorphenamine maleate

Product Name: Chlorphenamine maleate
CAS No.: 113-92-8
Chemical Name: Chlorphenamine maleate
Synonyms: chlorphenamine;CHLORPHENAMINE MALEATE;CHLORTRIMETON;CHLOROPHENIRAMINE MALEATE;CHLORPHENIRAMINE BASE;Puermin;piriton;teldrin;Histadur;antagonate
CBNumber: CB9142008
Molecular Formula: C20H23ClN2O4
Formula Weight: 390.86
MOL File: 113-92-8.mol

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Chlorphenamine maleate Property

Melting point:: 130-135 °C (lit.)
alpha: -1～+1°(D/20℃)(c=5,DMF)
Density: 1.1984 (rough estimate)
refractive index: 1.6800 (estimate)
Flash point:: 9℃
storage temp.: 2-8°C
solubility: Freely soluble in water, soluble in ethanol (96 per cent)
color: White to Almost white
Odor: odorless
PH: 4.0～5.5 (10g/l, 25℃)
Water Solubility: 1-5 g/100 mL at 21 ºC
Merck: 14,2180
BCS Class: 3/1
InChIKey: DBAKFASWICGISY-BTJKTKAUSA-N
LogP: 3.389 (est)
EPA Substance Registry System: Chlorpheniramine maleate (113-92-8)

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Safety

Hazard Codes: T,F
Risk Statements: 25-39/23/24/25-23/24/25-11
Safety Statements: 36/37/39-45-36/37-16
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: US6504000
TSCA: Yes
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29333990
Toxicity: LD50 orally in mice: 162 mg/kg (Smith)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C-036
Product name: Chlorpheniramine maleate salt solution
Purity: 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $26.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1123000
Product name: Chlorpheniramine maleate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 125mg
Price: $358
Updated: 2024/03/01

Sigma-Aldrich

Product number: BP081
Product name: Chlorphenamine maleate
Purity: British Pharmacopoeia (BP) Reference Standard
Packaging: 100MG
Price: $252
Updated: 2023/01/07

TCI Chemical

Product number: C0873
Product name: Chlorpheniramine Maleate
Purity: >99.0%(HPLC)(T)
Packaging: 25g
Price: $74
Updated: 2024/03/01

Alfa Aesar

Product number: B25238
Product name: Chlorpheniramine maleate, 99%
Packaging: 5g
Price: $38.65
Updated: 2024/03/01

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Chlorphenamine maleate Chemical Properties,Usage,Production

Description

Chlorpheniramine is a histamine H₁ receptor antagonist with an IC₇₅ value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD₅₀ = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED_100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.

Chemical Properties

White Solid

Uses

An antagonist of the histamine H1-receptor

Uses

(±)-Chlorpheniramine maleate salt has been used:

as H1 receptor antagonist to determine the receptor function
to block the effect of compound 48/80 on plasma IGF-I
as a standard for fast sensing and determination by sequential injector coupled with potentiometer

Uses

Antihistaminic

Definition

ChEBI: Chlorpheniramine maleate is an organic molecular entity.

brand name

Trimeton (Schering-Plough); Teldrin (GlaxoSmithKline).

General Description

Chlorpheniraminemaleate, (±)2-[p-chloro-α-[2-dimethylamino)ethyl]benzyl]pyridine bimaleate (Chlor-Trimeton), is a white crystallinepowder that is soluble in water (1:3.4), in alcohol(1:10), and in chloroform (1:10). It has a pKa of 9.2, and anaqueous solution has a pH between 4 and 5. Chlorination ofpheniramine in the para position of the phenyl ring increasespotency 10-fold with no appreciable change in toxicity.Most of the antihistaminic activity resides with thedextro isomer (see under “Dexchlorpheniramine Maleate” ).The usual dose is 2 to 4 mg 3 or 4 times a day. It has a halflifeof 12 to 15 hours.

General Description

Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.

Air & Water Reactions

Water soluble.

Reactivity Profile

A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.

Biochem/physiol Actions

Chlorpheniramine maleate (CPM) can prevent rhinitis and urticaria. It is used to cure several allergic conditions. This antihistamine is used in small-animal veterinary practices.

Safety Profile

Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.

Veterinary Drugs and Treatments

Antihistamines are used in veterinary medicine to reduce or help prevent histamine mediated adverse effects. Chlorpheniramine is one the more commonly used antihistamines in the cat for the treatment of pruritus. It may also be of benefit as a mild sedative in small animals due to its CNS depressant effects.

Dosage forms

4 to 6 mg PO q4–6h. Maximum daily dose is 24 mg for adults and children 12 years or older. Found frequently in combination with acetaminophen and pseudoephedrine.

Chlorphenamine maleate Preparation Products And Raw materials

Raw materials

Maleic acid 2-Picoline Bromoacetaldehyde diethyl acetal 2-(4-Chlorobenzyl)pyridine Anhydrous toluene

Preparation Products

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View Lastest Price from Chlorphenamine maleate manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Chlorphenamine maleate 113-92-8
Price: US $80.00-60.00/KG
Min. Order: 1KG
Purity: 99.9%
Supply Ability: 1000
Release date: 2024-03-18

hebei hongtan Biotechnology Co., Ltd

Product: Chlorpheniramine maleate 113-92-8
Price: US $50.00-30.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 500
Release date: 2024-03-18

Henan Suikang Pharmaceutical Co.,Ltd.

Product: Chlorphenamine maleate 113-92-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%
Supply Ability: 1tons
Release date: 2024-04-26

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Chlorphenamine hydrogen maleate

Chlorpheniramine maleate 113-92-8

Chlorpheniramine maleate, 99%, a histamine H1 receptor antagonist

1-(p-chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropanmaleat

2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-pyridinmaleate(1:1)

allerclor

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antagonate

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dl-2-(p-chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridinemaleate

gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioa

gamma-(4-chlorophenyl)-n,n-dimethyl-2-pyridinepropanamin(z)-2-butenedioate

histadurdura-tabs

ibioton

lorphen

m.p.chlorcapst.d.

nci-c55265