Succimer
- Product Name
- Succimer
- CAS No.
- 304-55-2
- Chemical Name
- Succimer
- Synonyms
- DMSA;MESO-2,3-DIMERCAPTOSUCCINIC ACID;chemet;dim-sa;uccimer;ro1-7977;SUCCIMER;AI312104;MESO-DMSA;AI3 12104
- CBNumber
- CB9142563
- Molecular Formula
- C4H6O4S2
- Formula Weight
- 182.22
- MOL File
- 304-55-2.mol
Succimer Property
- Melting point:
- 196-198 °C (dec.)(lit.)
- Boiling point:
- 285.62°C (rough estimate)
- Density
- 1.439 (estimate)
- refractive index
- 1.5220 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO (Sparingly), Methanol (Slightly, Heated)
- form
- Powder
- pka
- pK1:2.71;pK2:3.48;pK3:8.89(SH);pK4:10.79(SH) (25°C)
- color
- White to off-white
- Water Solubility
- Soluble in water, and ethanol (25 mg/ml, results in colorless to light yellow, clear).
- Merck
- 14,8865
- BRN
- 1725150
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- ACTRVOBWPAIOHC-XIXRPRMCSA-N
- CAS DataBase Reference
- 304-55-2(CAS DataBase Reference)
- EPA Substance Registry System
- Butanedioic acid, 2,3-dimercapto-, (2R,3S)-rel- (304-55-2)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 24/25-36-26
- WGK Germany
- 2
- RTECS
- WM7650000
- F
- 10-23
- TSCA
- Yes
- HS Code
- 29309090
- Hazardous Substances Data
- 304-55-2(Hazardous Substances Data)
- Toxicity
- LD50 i.p. in mice: >3000 mg/kg (Friedheim, Corvi)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D7881
- Product name
- meso-2,3-Dimercaptosuccinic acid
- Purity
- ~98%
- Packaging
- 1g
- Price
- $30.9
- Updated
- 2024/03/01
- Product number
- D7881
- Product name
- meso-2,3-Dimercaptosuccinic acid
- Purity
- ~98%
- Packaging
- 5g
- Price
- $88
- Updated
- 2024/03/01
- Product number
- D1722
- Product name
- meso-2,3-Dimercaptosuccinic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $70
- Updated
- 2024/03/01
- Product number
- D1722
- Product name
- meso-2,3-Dimercaptosuccinic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $269
- Updated
- 2024/03/01
- Product number
- A17909
- Product name
- meso-2,3-Dimercaptosuccinic acid, 97%
- Packaging
- 1g
- Price
- $29.65
- Updated
- 2024/03/01
Succimer Chemical Properties,Usage,Production
Description
Succimer is a newly available oral chelator of lead and other heavy metals. The compound is indicated for the treatment of lead poisoning in children. Succimer does not bind iron, calcium or magnesium and preferentially binds lead, mercury and arsenic over copper or zinc. The metal-bound succimer is excreted in the urine. The drug may also be effective in adults.
Chemical Properties
white or off-white powder
Originator
Johnson and Johnson (J&J) (U.S.A.)
Uses
chelating agent, antihypertensive
Uses
meso-2,3-Dimercaptosuccinic Acid is used as a chelating agent and masking agent for cadmium in EDTA titration of zinc.
Uses
A water-soluble chelating agent.
Uses
chelating agent, treatment of lead poisoning
Preparation
Isolate
the solid complexes of trivalent lanthanide complexes with
meso-2,3-Dimercaptosuccinic Acid, furan-2-carboxylic acid,
meso-2,3-dimercaptosuccinic acid and sarcosine from the mixture of
equimolar solutions of metal nitrates and ligands. Adjust the pH of the
mixture to 7 by adding dilute solution of KOH. Reflux the mixture in
ethanol (15-20 ml) for 3-4 hours on a steam bath. The clear solution
gives a solid mass on cooling, filter through G4 glass crucible and wash
several times with the mixture of doubly distilled water and alcohol.
Recrystallise it to obtain pure crystal and dry at 60 ?? -70 ??C [1].
Definition
ChEBI: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
brand name
Chemet (Ovation).
Pharmaceutical Applications
Dimercaptosuccinic acid (DMSA) is a modification of BAL containing two thiol groups, which are responsible for the unpleasant
smell, and two carboxylic acid groups. DMSA is also known under the name Succimer. It chemical name
is meso-2,3-dimercaptosuccinic acid and the chemical formula is HO2CCH(SH)CH(SH)CO2H. There are
two diastereomeric forms, meso and the chiral DL forms, with the meso isomer being used as chelating agent.
DMSA was developed in the 1960s and replaced BAL and edetate in some countries for the treatment
of lead, arsenic and mercury poisoning. Furthermore, the dimethylester modification of DMSA has been
successfully used for the treatment of heavy-metal poisoning.
Pharmaceutical Applications
The unlicensed drug Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) may be valuable in the treatment of most forms of heavy-metal poisoning including lead, arsenic and mercury. These and other chelating agents such as unithiol (DMPS, 2,3-dimercapto-1-propanesulfonic acid) and α-lipoic acid (ALA) are also used in alternative medicine, which has led to much criticism and discussion. So far, no medical study has proven the effectiveness of chelation therapy for any clinical application other than heavy-metal poisoning.
Veterinary Drugs and Treatments
In veterinary medicine, succimer may be useful for the oral treatment of lead poisoning in small animals (including birds). Potentially, it also may be of benefit for the treatment of other toxic heavy metals such as arsenic or mercury, but more research must be done before this can be recommended.
Purification Methods
Purify the acid by dissolving it in NaOH and precipitating with dilute HCl, drying and recrystallising from MeOH. IR has at 2544 (SH) and max 1689 (CO2H) cm-1 . The bis-S-acetyl derivative has m 183-185o (from EtOAc or Me2CO), and its Me ester has m 119-120o (from pet ether) [Gerecke et al. Helv Chim Acta 44 957 1961, Owen & Sultanbawa J Chem Soc 3112 1949]. [Beilstein 3 III 1033.]
Succimer Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Succimer manufacturers
- Product
- Succimer 304-55-2
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2023-05-17
- Product
- 2,3-Dimercaptosuccinic Acid 304-55-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 2Kg/Bag
- Purity
- 98% up / CP2015
- Supply Ability
- 20 tons
- Release date
- 2022-08-24
- Product
- Succimer 304-55-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons miin
- Release date
- 2021-05-25