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Arformoterol tartrate

Product Name
Arformoterol tartrate
CAS No.
200815-49-2
Chemical Name
Arformoterol tartrate
Synonyms
200-589-5;Aphmote tartrate;Aforterol tartrate;R,R-Form L-tartrate;Afromoterol tartrate;Arformoterol tartrate;(R,R)-Formoterol tartrate;(R,R)-ForMoterol-L-(+)-Tartrate;Formoterol Impurity 23 Tartrate;Formoterol Impurity 28 Tartrate
CBNumber
CB91459486
Molecular Formula
C19H24N2O4.C4H6O6
Formula Weight
494.494
MOL File
200815-49-2.mol
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Arformoterol tartrate Property

Melting point:
184°
storage temp. 
Refrigerator, Under Inert Atmosphere
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly, Heated, Sonicated)
form 
Solid
color 
White to Pale Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H331Toxic if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H351Suspected of causing cancer

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P281Use personal protective equipment as required.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P311Call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23935
Product name
Arformoterol (tartrate)
Purity
≥98%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
23935
Product name
Arformoterol (tartrate)
Purity
≥98%
Packaging
10mg
Price
$143
Updated
2024/03/01
Cayman Chemical
Product number
23935
Product name
Arformoterol (tartrate)
Purity
≥98%
Packaging
25mg
Price
$336
Updated
2024/03/01
Cayman Chemical
Product number
23935
Product name
Arformoterol (tartrate)
Purity
≥98%
Packaging
50mg
Price
$588
Updated
2024/03/01
Tocris
Product number
6219
Product name
Arformoteroltartrate
Purity
≥98%(HPLC)
Packaging
50
Price
$455
Updated
2021/12/16
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Arformoterol tartrate Chemical Properties,Usage,Production

Description

Sepracor’s Brovana®, a nebulized long acting bronchodilator, was launched in the U.S. in April 2007. The β2- adrenoceptor agonist is indicated for the twice-daily, longtermmaintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), which includes chronic bronchitis and emphysema. It is the first long-acting nebulized bronchodilator approved by the FDA for this indication.

Description

Aformoterol is the (R,R)-enantiomer of the β2-adrenergic receptor (β2-AR) agonist formoterol . It selectively binds to β1- over β2-ARs (Kds = 2.9 and 113 nM, respectively) as well as β3-adrenergic, B2 bradykinin, neurokinin 1 (NK1) and NK2 receptors when used at concentrations up to 3 μM. Aformoterol induces cAMP accumulation in cultured human bronchial epithelial cells. Ex vivo, aformoterol (0.01-1,000 nM) induces dose-dependent relaxation of guinea pig tracheal strips precontracted with carbamoylcholine , ovalbumin, or histamine (pD2s = 8.4, 9.5, and 9.5, respectively). In vivo, aformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s = 1 and 40 nmol/kg, respectively). Formulations containing aformoterol have been used in the treatment of chronic obstructive pulmonary disease (COPD).

Uses

Arformoterol Tartrate, can be used in the synthesis of Omeprazole (O635000), which is a proton pump inhibitor, that inhibits gasteric secretion, also used in the treatment of dyspepsia, peptic ulcer disease, etc. It is also the impurity of Esomeprazole Magnesium (E668300), which is the S-form of Omeprazole, and is a gastric proton-pump inhibitor. Also, It can be used for the preparation of olodaterol, a novel inhaled β2-adrenoceptor agonist with a 24h bronchodilatory efficacy.

Uses

Anti-asthmatic and bronchodilator.

Synthesis

There are several reports on the synthesis of arformoterol. A large-scale synthesis of enantio/diastereomerically pure (R,R)-formoterol is cited here. Bromoalcohol 22 was synthesized in 84% yield with 94% e.e. through the catalytic enantioselective reduction of bromo ketone 21. The nitro functional group in 22 was reduced in quantitative yield by hydrogena-tion in the presence of Adams catalyst and the resulting aniline was isolated by filtration of the catalyst and removal of the solvent. In order to avoid auto-oxidation, the aniline was treated with a mixture of formic acid and acetic anhydride immediately after the removal of the platinum catalyst. Upon concentrating the reaction mixture, bromohydrin 23 crystallized and could be isolated in 75% yield with 98.6% e.e. It was further enriched to >99.5% e.e. by a single re-crystallization from ethylacetate. Next, a mixture of bromohydrin 23 and amine salt (R)-26-(S)-mandelic acid was treated with K2CO3 resulting in generation of the corresponding epoxide of 23 and liberation of the free base of (R)-26. After an aqueous work up to remove salts and mandelic acid, the reaction mixture was heated to 120??C to affect epoxide opening with the amine of 26. Removal of the benzyl protecting groups of the resulting crude product via catalytic hydrogenation followed by salt formation with tartaric acid afforded arformoterol tartrate (III) in 70% yield upon crystallization.

storage

Store at +4°C

Arformoterol tartrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Arformoterol tartrate Suppliers

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View Lastest Price from Arformoterol tartrate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Arformoterol tartrate 200815-49-2
Price
US $85.00-850.00/kg
Min. Order
10kg
Purity
0.99
Supply Ability
20tons
Release date
2023-11-20
Wuhan Senwayer Century Chemical Co.,Ltd
Product
Arformoterol tartrate 200815-49-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 TONS
Release date
2022-11-07
Henan Bao Enluo International TradeCo.，LTD
Product
Arformoterol tartrate 200815-49-2
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000tons
Release date
2023-08-23

200815-49-2, Arformoterol tartrateRelated Search:

Tylosin tartrate Methoxydiethylborane 4-Methoxyphenylacetone p-(2-Methoxyethyl) phenol Tylosin tartrate Potassium antimonyl tartrate sesquihydrate CHLOROPHOSPHONAZO III Formoterol fumarate dihydrate Metoprolol tartrate Zolpidem tartrate Formoterol (Trifluoromethoxy)benzene L-Carnitine-L-tartrate Anisole D(-)-Tartaric acid Diphenylsilanediol Formamide, N-[2-hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]-, [S-(R*,S*)]- Arformoterol Impurity 24

  • N-[2-Hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide L-tartrate
  • Arformoterol tartrate
  • Afromoterol tartrate
  • (R,R)-Formoterol tartrate
  • N-(2-Hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)formamide (2R,3R)-2,3-dihydroxybutanedioate (1:1)
  • (-)-ForMoterol-d6 L-Tartrate , ArforMoterol-d6 L-Tartrate
  • (R,R)-(-)-ForMoterol-d6 Tartrate
  • (R,R)-ForMoterol-L-(+)-Tartrate API
  • (R,R)-ForMoterol-L-(+)-Tartrate
  • R,R-Form L-tartrate
  • (2R,3R)-2,3-dihydroxybutanedioic acid,N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2R)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide
  • R-[4-(benzyloxy)-3-(formanmino)phenyl]oxirane
  • Arformoterol tartrate Solution in Methanol, 100μg/mL
  • (R,R)-(-)-Formoterol tartrate salt
  • 200-589-5
  • Aphmote tartrate
  • (R,R)-Formoterol tartrate (Arformoterol tartrate)
  • Formoterol Impurity 23 Tartrate
  • Aforterol tartrate
  • Formoterol Impurity 28 Tartrate
  • 200815-49-2
  • 00815-49-2
  • C19H24N2O4C4H6O6
  • C23H30N2O10
  • APIs