ChemicalBook > CAS DataBase List > 1 NM-PP1

1 NM-PP1

Product Name
1 NM-PP1
CAS No.
221244-14-0
Chemical Name
1 NM-PP1
Synonyms
CS-920;1 NM-PP1;NM-PP1, 1-;Chebi:52309;PP1 ANALOG II;PP1 Analog II, 1NM-PP1;1NM-PP1(PP1 Analog II);MUTANT KINASES INHIBITOR II;PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem;4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE
CBNumber
CB9146400
Molecular Formula
C20H21N5
Formula Weight
331.41
MOL File
221244-14-0.mol
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1 NM-PP1 Property

Melting point:
175-176°C
Boiling point:
545.7±45.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
White solid
pka
4.50±0.30(Predicted)
color 
White to Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H272May intensify fire; oxidizer

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P221Take any precaution to avoid mixing with combustibles/…

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
529606
Product name
InSolution PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
Packaging
1mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
529581
Product name
PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
Purity
PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over wild-type kinases.
Packaging
1mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
13330
Product name
1-NM-PP1
Purity
≥95%
Packaging
1mg
Price
$75
Updated
2024/03/01
Cayman Chemical
Product number
13330
Product name
1-NM-PP1
Purity
≥95%
Packaging
5mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
13330
Product name
1-NM-PP1
Purity
≥95%
Packaging
10mg
Price
$263
Updated
2024/03/01
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1 NM-PP1 Chemical Properties,Usage,Production

Description

1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.

Chemical Properties

White Cyrstalline Solid

Uses

A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase

Definition

ChEBI: 1-NM-PP1 is a pyrazolopyrimidine. It has a role as a tyrosine kinase inhibitor.

References

[1] bishop ac1, ubersax ja, petsch dt, matheos dp, gray ns, blethrow j, shimizu e, tsien jz, schultz pg, rose md, wood jl, morgan do, shokat km. a chemical switch for inhibitor-sensitive alleles of any protein kinase. nature. 2000 sep 21; 407 (6802): 395-401.

1 NM-PP1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1 NM-PP1 Suppliers

Canada 1 China 90 India 1 United Kingdom 2 United States 18 Global 112
MedChemexpress LLC
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View Lastest Price from 1 NM-PP1 manufacturers

Career Henan Chemical Co
Product
1 NM-PP1 221244-14-0
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1lg; 2kg; 5kg; 10kg; 100kg
Release date
2019-08-31

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  • 4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE
  • 4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE
  • 1 NM-PP1
  • MUTANT KINASES INHIBITOR II
  • PP1 ANALOG II
  • 1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 1-tert-Butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-D]pyrimidin-4-amine
  • Chebi:52309
  • PP1 Analog II, 1NM-PP1
  • 4-Amino-1-tert-butyl-3-(1a€-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
  • 1NM-PP1(PP1 Analog II)
  • NM-PP1, 1-
  • PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
  • CS-920
  • 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1,1-dimethylethyl)-3-(1-naphthalenylmethyl)-
  • 1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine
  • 4-Amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine
  • 221244-14-0
  • Inhibitors
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
  • API