Boc-3-amino-2,2-dimethyl-propionic acid
- Product Name
- Boc-3-amino-2,2-dimethyl-propionic acid
- CAS No.
- 180181-02-6
- Chemical Name
- Boc-3-amino-2,2-dimethyl-propionic acid
- Synonyms
- 3-((tert-Butoxycarbonyl)aMino)-2,2-diMethylpropanoic acid;N-Boc-3-Amino-2,2-dimethyl-propi;3-(Boc-amino)-2,2-dimethylpropionic;3-BOCAMINO-2,2-DIMETHYL-PROPIONIC ACID;Boc-3-amino-2,2-dimethyl-propionic acid;N-Boc-3-amino-2,2-dimethylpropionic acid;3-(Boc-amino)-2,2-dimethylpropanoic acid;2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl);3-(tert-butoxycarbonyl)-2,2-dimethylpropanoic acid;tert-butyl 3-allyl-3-hydroxyazetidine-41-carboxylate
- CBNumber
- CB91466600
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 180181-02-6.mol
Boc-3-amino-2,2-dimethyl-propionic acid Property
- Boiling point:
- 346.5±25.0 °C(Predicted)
- Density
- 1.082±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder
- pka
- 4.61±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- 1S/C10H18O4/c1-9(2,3)14-7(11)6-10(4,5)8(12)13/h6H2,1-5H3,(H,12,13)
- InChIKey
- BCUIGUVXRMEZDV-UHFFFAOYSA-N
- SMILES
- CC(C)(C)OC(CC(C)(C(O)=O)C)=O
Safety
- WGK Germany
- WGK 3
- HS Code
- 29225090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- PH017156
- Product name
- 2-(Phenylsulfanyl)nicotinoyl chloride
- Purity
- AldrichCPR
- Packaging
- 500MG
- Price
- $75.3
- Updated
- 2022/05/15
- Product number
- D461830
- Product name
- 2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl)
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 265958
- Product name
- Boc-3-amino-2,2-dimethyl-propionic acid
- Packaging
- 250mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- D461830
- Product name
- 2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl)
- Packaging
- 2.5g
- Price
- $1020
- Updated
- 2021/12/16
- Product number
- FB52625
- Product name
- Boc-3-amino-2,2-dimethyl-propionic acid
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
Boc-3-amino-2,2-dimethyl-propionic acid Chemical Properties,Usage,Production
Uses
2,2-Dimethyl-β-alanine-N-(tert-butoxycarbonyl) is used as a reactant in the synthesis of cryptophycin anticancer agents.
Synthesis
19036-43-2
24424-99-5
180181-02-6
Example 6: Synthesis of 3-(tert-butoxycarbonylamino)-2,2-dimethylpropionic acid (19) [00156] Under argon protection, 3-amino-2,2-dimethylpropionic acid (18) (1.2 g, 10.2 mmol), di-tert-butyl dicarbonate (Boc anhydride) (2.3 g, 10.2 mmol) and N,N-diisopropylethylamine (DIPEA) (1.85 mL, 10.23 mmol) were dissolved in N,N-dimethylformamide (DMF) (30 mL) in N,N-dimethylformamide (DMF) and the reaction was stirred at 60°C for 16 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure, the residue was dissolved in ethyl acetate (EtOAc), washed with saturated ammonium chloride (NH4Cl) solution, and the organic phase was concentrated again under reduced pressure to afford the title compound 3-(tert-butoxycarbonylamino)-2,2-dimethylpropanoic acid (19) (2.0 g, 91% yield). 1H NMR (300 MHz, CDCl3) δ 1.33 (s, 6H), 1.37 (s, 9H), 2.69 (s, 2H).
References
[1] Patent: WO2011/32291, 2011, A1. Location in patent: Page/Page column 47
[2] Journal of Organic Chemistry, 2010, vol. 75, # 20, p. 6953 - 6960
[3] Patent: US2015/210635, 2015, A1. Location in patent: Paragraph 0483-0485
[4] Patent: EP2865664, 2015, A1. Location in patent: Paragraph 0105; 0106
[5] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8277 - 8280
Boc-3-amino-2,2-dimethyl-propionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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