3-Amino-2-chloro-6-iodopyridine
- Product Name
- 3-Amino-2-chloro-6-iodopyridine
- CAS No.
- 400777-06-2
- Chemical Name
- 3-Amino-2-chloro-6-iodopyridine
- Synonyms
- 6-chloro-2-iodopyridin-3-amine;3-Amino-6-chloro-2-iodopyridine;3-Amino-2-chloro-6-iodopyridine;2-Iodo-6-chloro-pyridin-3-amine;3-Pyridinamine, 6-chloro-2-iodo-;6-chloro-2-iodo-pyridin-3-ylamine;2-Iodine-3-amino-6-chloropyridine;3-Amino-2-chloro-6-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB91471178
- Molecular Formula
- C5H4ClIN2
- Formula Weight
- 254.46
- MOL File
- 400777-06-2.mol
3-Amino-2-chloro-6-iodopyridine Property
- Boiling point:
- 359.4±42.0 °C(Predicted)
- Density
- 2.139
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.12±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C349530
- Product name
- 6-Chloro-2-iodopyridin-3-amine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C349530
- Product name
- 6-Chloro-2-iodopyridin-3-amine
- Packaging
- 25mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C349530
- Product name
- 6-Chloro-2-iodopyridin-3-amine
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- W6049
- Product name
- 6-Chloro-2-iodopyridin-3-amine
- Packaging
- 250mg
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 059291
- Product name
- 6-Chloro-2-iodopyridin-3-amine
- Purity
- >95%
- Packaging
- 250mg
- Price
- $98
- Updated
- 2021/12/16
3-Amino-2-chloro-6-iodopyridine Chemical Properties,Usage,Production
Uses
3-Amino-2-chloro-6-iodopyridine is a pyridine based building block used in organic synthesis.
Synthesis
5350-93-6
400777-06-2
Step a: Synthesis of 6-chloro-2-iodopyridin-3-amine To a solution of 6-chloropyridin-3-amine (10.0 g, 77.8 mmol) in ethanol (150 mL) was sequentially added silver sulfate (12.1 g, 38.9 mmol) and iodine (23.7 g, 93.4 mmol). The reaction mixture was stirred at 20 °C overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Water (100 mL) and ethyl acetate (200 mL) were added to the residue and the organic layer was separated. The aqueous layer was extracted three times with ethyl acetate (100 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=7:1) to afford 6-chloro-2-iodopyridin-3-amine (17.1 g, 86% yield). 1H NMR (DMSO, 300MHz) δ 7.16 (d, J = 8.4Hz, 1H), 7.01 (d, J = 8.4Hz, 1H), 5.57 (s, 2H).
References
[1] Patent: US2009/253736, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: EP2826781, 2015, A1. Location in patent: Paragraph 0077-0078
[3] Patent: KR2015/9461, 2015, A. Location in patent: Paragraph 0195; 0196
[4] Patent: WO2013/10880, 2013, A1. Location in patent: Page/Page column 82
[5] Patent: EP2548876, 2013, A1. Location in patent: Paragraph 0275-0278
3-Amino-2-chloro-6-iodopyridine Preparation Products And Raw materials
Raw materials
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View Lastest Price from 3-Amino-2-chloro-6-iodopyridine manufacturers
- Product
- 3-Amino-2-chloro-6-iodopyridine 400777-06-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03