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5-Bromo-2-fluoropyridine-3-carboxaldehyde

Product Name
5-Bromo-2-fluoropyridine-3-carboxaldehyde
CAS No.
875781-15-0
Chemical Name
5-Bromo-2-fluoropyridine-3-carboxaldehyde
Synonyms
5-bromo-2-fluoronicotinaldehyde;5-Bromo-2-fluoro-3-formylpyridine;5-Bromo-2-fluoro-pyridin-3-carbaldehyde;5-Bromo-2-fluoro-3-pyridinecarboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-;5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH;5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine
CBNumber
CB91471279
Molecular Formula
C6H3BrFNO
Formula Weight
204
MOL File
875781-15-0.mol
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5-Bromo-2-fluoropyridine-3-carboxaldehyde Property

Boiling point:
258.2±35.0 °C(Predicted)
Density 
1.778±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-4.59±0.20(Predicted)
form 
Powder
color 
Off-white to pale yellow
InChI
InChI=1S/C6H3BrFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H
InChIKey
MUYVOGAJRCBWCY-UHFFFAOYSA-N
SMILES
C1(F)=NC=C(Br)C=C1C=O
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Safety

Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B685160
Product name
5-Bromo-2-fluoro-3-pyridinecarboxaldehyde
Packaging
500mg
Price
$165
Updated
2021/12/16
AK Scientific
Product number
W8985
Product name
5-Bromo-2-fluoro-3-pyridinecarboxaldehyde
Packaging
10g
Price
$144
Updated
2021/12/16
SynQuest Laboratories
Product number
4H15-B-01
Product name
5-Bromo-2-fluoronicotinaldehyde
Packaging
25g
Price
$300
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0143437
Product name
5-BROMO-2-FLUORO-3-PYRIDINECARBOXALDEHYDE
Purity
95.00%
Packaging
1G
Price
$687.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0143437
Product name
5-BROMO-2-FLUORO-3-PYRIDINECARBOXALDEHYDE
Purity
95.00%
Packaging
5G
Price
$1193.12
Updated
2021/12/16
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5-Bromo-2-fluoropyridine-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde is used in the synthesis of [2,3-d]pyrimidine derivatives useful as Raf kinase inhibitors. Also used in the preparation of XIa inhibitors.

Synthesis

2591-86-8

766-11-0

875781-15-0

The general procedure for the synthesis of 5-bromo-2-fluoro-3-formylpyridine using N-formylpiperidine and 2-fluoro-5-bromopyridine as starting materials was as follows: the intermediate 5-bromo-1H-pyrazolo[3,4-b]pyridine was first prepared; subsequently, the crude product was ground in hexane (replacing the operation of crystallization from cyclohexane) according to the method described in WO2006015124 to obtain the target compound 5-bromo-2-fluoro-3-formylpyridine, the product was an off-white solid in 68% yield. Mass spectrometry (electrospray positive ion mode) showed m/z of 203.8 and 205.7 [M+H]+.

References

[1] Patent: US2008/293706, 2008, A1. Location in patent: Page/Page column 27; 85
[2] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 73-74

5-Bromo-2-fluoropyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-fluoropyridine-3-carboxaldehyde Suppliers

China 176 Germany 1 India 4 United Kingdom 1 United States 13 Global 195
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 5-Bromo-2-fluoropyridine-3-carboxaldehyde manufacturers

Hebei Zhanyao Biotechnology Co. Ltd
Product
5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-15
Dideu Industries Group Limited
Product
5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-08-20
Shaanxi Dideu Medichem Co. Ltd
Product
5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%
Supply Ability
500 MT
Release date
2020-05-12

875781-15-0, 5-Bromo-2-fluoropyridine-3-carboxaldehydeRelated Search:

5-Bromo-3-formylpyridine 5-Bromo-2-fluoropyridine 2-Bromo-5-fluoropyridine 5-BROMO-2-FLUORONICOTINIC ACID 2-Fluoro-5-bromo-3-methylpyridine 5-Bromo-2-fluoropyridine-3-carboxaldehyde

  • 5-Bromo-2-fluoro-pyridin-3-carbaldehyde
  • 5-bromo-2-fluoronicotinaldehyde
  • 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde
  • 5-Bromo-2-fluoro-3-formylpyridine
  • 5-Bromo-2-fluoropyridine-3-carboxaldehyde
  • 5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine
  • 3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-
  • 5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH
  • 875781-15-0
  • Building Blocks
  • Pyridine
  • Fluorine series