5-Bromo-2-fluoropyridine-3-carboxaldehyde

Product Name: 5-Bromo-2-fluoropyridine-3-carboxaldehyde
CAS No.: 875781-15-0
Chemical Name: 5-Bromo-2-fluoropyridine-3-carboxaldehyde
Synonyms: 5-bromo-2-fluoronicotinaldehyde;5-Bromo-2-fluoro-3-formylpyridine;5-Bromo-2-fluoro-pyridin-3-carbaldehyde;5-Bromo-2-fluoro-3-pyridinecarboxaldehyde;5-Bromo-2-fluoropyridine-3-carboxaldehyde;3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-;5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH;5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine
CBNumber: CB91471279
Molecular Formula: C6H3BrFNO
Formula Weight: 204
MOL File: 875781-15-0.mol

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5-Bromo-2-fluoropyridine-3-carboxaldehyde Property

Boiling point:: 258.2±35.0 °C(Predicted)
Density: 1.778±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -4.59±0.20(Predicted)
form: Powder
color: Off-white to pale yellow
InChI: InChI=1S/C6H3BrFNO/c7-5-1-4(3-10)6(8)9-2-5/h1-3H
InChIKey: MUYVOGAJRCBWCY-UHFFFAOYSA-N
SMILES: C1(F)=NC=C(Br)C=C1C=O

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Safety

Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B685160
Product name: 5-Bromo-2-fluoro-3-pyridinecarboxaldehyde
Packaging: 500mg
Price: $165
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B10986
Product name: 5-Bromo-2-fluoro-3-formylpyridine
Purity: 98%
Packaging: 1g
Price: $6
Updated: 2021/12/16

Apolloscientific

Product number: PC11103
Product name: 5-Bromo-2-fluoronicotinaldehyde
Packaging: 1g
Price: $12
Updated: 2021/12/16

Matrix Scientific

Product number: 068679
Product name: 5-Bromo-2-fluoropyridine-3-carboxaldehyde
Purity: >95%
Packaging: 1g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: B10986
Product name: 5-Bromo-2-fluoro-3-formylpyridine
Purity: 98%
Packaging: 5g
Price: $24
Updated: 2021/12/16

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5-Bromo-2-fluoropyridine-3-carboxaldehyde Chemical Properties,Usage,Production

Uses

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde is used in the synthesis of [2,3-d]pyrimidine derivatives useful as Raf kinase inhibitors. Also used in the preparation of XIa inhibitors.

Synthesis

2591-86-8

766-11-0

875781-15-0

The general procedure for the synthesis of 5-bromo-2-fluoro-3-formylpyridine using N-formylpiperidine and 2-fluoro-5-bromopyridine as starting materials was as follows: the intermediate 5-bromo-1H-pyrazolo[3,4-b]pyridine was first prepared; subsequently, the crude product was ground in hexane (replacing the operation of crystallization from cyclohexane) according to the method described in WO2006015124 to obtain the target compound 5-bromo-2-fluoro-3-formylpyridine, the product was an off-white solid in 68% yield. Mass spectrometry (electrospray positive ion mode) showed m/z of 203.8 and 205.7 [M+H]+.

References

[1] Patent: US2008/293706, 2008, A1. Location in patent: Page/Page column 27; 85
[2] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 73-74

5-Bromo-2-fluoropyridine-3-carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-2-fluoropyridine-3-carboxaldehyde Suppliers

China 176 Germany 1 India 4 United Kingdom 1 United States 13 Global 195

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View Lastest Price from 5-Bromo-2-fluoropyridine-3-carboxaldehyde manufacturers

Hebei Zhanyao Biotechnology Co. Ltd

Product: 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-10-15

Dideu Industries Group Limited

Product: 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-20

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Bromo-2-fluoropyridine-3-carboxaldehyde 875781-15-0
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-12

875781-15-0, 5-Bromo-2-fluoropyridine-3-carboxaldehydeRelated Search:

5-Bromo-3-formylpyridine 5-Bromo-2-fluoropyridine 2-Bromo-5-fluoropyridine 5-BROMO-2-FLUORONICOTINIC ACID 2-Fluoro-5-bromo-3-methylpyridine 5-Bromo-2-fluoropyridine-3-carboxaldehyde

5-Bromo-2-fluoro-pyridin-3-carbaldehyde

5-bromo-2-fluoronicotinaldehyde

5-Bromo-2-fluoro-3-pyridinecarboxaldehyde

5-Bromo-2-fluoro-3-formylpyridine

5-Bromo-2-fluoropyridine-3-carboxaldehyde

5-Bromo-2-fluoropyridine-3-carboxaldehyde, 5-Bromo-2-fluoro-3-formylpyridine

3-Pyridinecarboxaldehyde, 5-broMo-2-fluoro-

5-Bromo-2-fluoropyridine-3-carboxaldehyde ISO 9001：2015 REACH

875781-15-0

Building Blocks

Pyridine

Fluorine series