4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID

Product Name: 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
CAS No.: 18623-44-4
Chemical Name: 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
Synonyms: iCRT5;iCRT-5 (iCRT5);3-Thiazolidinebutanoic acid, 5-[(3,4-dimethoxyphenyl)methylene]-4-oxo-2-thioxo-;(Z)-4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
CBNumber: CB91489465
Molecular Formula: C16H17NO5S2
Formula Weight: 367.44
MOL File: 18623-44-4.mol

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4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Property

Boiling point:: 571.2±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 30 mg/ml)
pka: 4.59±0.10(Predicted)
form: solid
color: Yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0025155
Product name: 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
Purity: 95.00%
Packaging: 1G
Price: $765.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025155
Product name: 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
Purity: 95.00%
Packaging: 2.5G
Price: $1065.66
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0025155
Product name: 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1295.03
Updated: 2021/12/16

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4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Chemical Properties,Usage,Production

Description

iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1? IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1?Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2?Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3?Modulators of Wnt signaling show great promise in animal models of several cancers.4?Cell permeable.

Uses

iCRT5 is a selective CRT (β-catenin-responsive transcription) inhibitor.

References

1) Gonsalves?et al.?(2011),?An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway; Proc. Natl. Acad. Sci. USA,?108?5954 2) Bilir?et al. (2013),?Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells; J. Transl. Med.,?11?280 3) Kafer?et al.?(2016),?Inhibitors of β-catenin affect the immune-phenotype and functions of dendritic cells in an inhibitor-specific manner; Immunopharmacol.,?32?118 4) Anastas?et al. (2013),?WNT signaling pathways as therapeutic targets in cancer; Nat. Rev. Cancer,?13?11

4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Suppliers

China 17 Ukraine 2 United States 4 Global 23

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18623-44-4, 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACIDRelated Search:

NSC59984 HSP70 modulator 115-7c Stattic NUTLIN-3 AKOS BBS-00007926 4-(4-OXO-2-THIOXO-THIAZOLIDIN-3-YL)-BUTYRIC ACID 4-[4-OXO-2-THIOXO-5-(3,4,5-TRIMETHOXY-BENZYLIDENE)-THIAZOLIDIN-3-YL]-BUTYRIC ACID AKOS BBS-00007905 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID

iCRT5

(Z)-4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid

iCRT-5 (iCRT5)

3-Thiazolidinebutanoic acid, 5-[(3,4-dimethoxyphenyl)methylene]-4-oxo-2-thioxo-

18623-44-4