4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- Product Name
- 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- CAS No.
- 18623-44-4
- Chemical Name
- 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- Synonyms
- iCRT5;iCRT-5 (iCRT5);3-Thiazolidinebutanoic acid, 5-[(3,4-dimethoxyphenyl)methylene]-4-oxo-2-thioxo-;(Z)-4-(5-(3,4-dimethoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)butanoic acid
- CBNumber
- CB91489465
- Molecular Formula
- C16H17NO5S2
- Formula Weight
- 367.44
- MOL File
- 18623-44-4.mol
4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Property
- Boiling point:
- 571.2±60.0 °C(Predicted)
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 30 mg/ml)
- pka
- 4.59±0.10(Predicted)
- form
- solid
- color
- Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- CHM0025155
- Product name
- 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $765.23
- Updated
- 2021/12/16
- Product number
- CHM0025155
- Product name
- 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1065.66
- Updated
- 2021/12/16
- Product number
- CHM0025155
- Product name
- 4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1295.03
- Updated
- 2021/12/16
4-[5-(3,4-DIMETHOXY-BENZYLIDENE)-4-OXO-2-THIOXO-THIAZOLIDIN-3-YL]-BUTYRIC ACID Chemical Properties,Usage,Production
Description
iCRT5 (18623-44-4) is a selective CRT (β-catenin-responsive transcription) inhibitor.1? IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1?Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2?Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3?Modulators of Wnt signaling show great promise in animal models of several cancers.4?Cell permeable.
Uses
iCRT5 is a selective CRT (β-catenin-responsive transcription) inhibitor.
References
1) Gonsalves?et al.?(2011),?An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway; Proc. Natl. Acad. Sci. USA,?108?5954 2) Bilir?et al. (2013),?Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells; J. Transl. Med.,?11?280 3) Kafer?et al.?(2016),?Inhibitors of β-catenin affect the immune-phenotype and functions of dendritic cells in an inhibitor-specific manner; Immunopharmacol.,?32?118 4) Anastas?et al. (2013),?WNT signaling pathways as therapeutic targets in cancer; Nat. Rev. Cancer,?13?11